CA2056981A1 - Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof - Google Patents

Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof

Info

Publication number
CA2056981A1
CA2056981A1 CA002056981A CA2056981A CA2056981A1 CA 2056981 A1 CA2056981 A1 CA 2056981A1 CA 002056981 A CA002056981 A CA 002056981A CA 2056981 A CA2056981 A CA 2056981A CA 2056981 A1 CA2056981 A1 CA 2056981A1
Authority
CA
Canada
Prior art keywords
protein
tgf
activity
tumor growth
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002056981A
Other languages
English (en)
French (fr)
Inventor
Kenneth K. Iwata
John R. Stephenson
Peter Ten Dijke
Robert Franco
Leslie I. Gold
J. Gordon Foulkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSI Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2056981A1 publication Critical patent/CA2056981A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002056981A 1989-05-17 1990-05-17 Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof Abandoned CA2056981A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35341089A 1989-05-17 1989-05-17
US353,410 1989-05-17

Publications (1)

Publication Number Publication Date
CA2056981A1 true CA2056981A1 (en) 1990-11-18

Family

ID=23388978

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002056981A Abandoned CA2056981A1 (en) 1989-05-17 1990-05-17 Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof

Country Status (5)

Country Link
EP (1) EP0508983A4 (ja)
JP (1) JPH04505325A (ja)
AU (1) AU668072B2 (ja)
CA (1) CA2056981A1 (ja)
WO (1) WO1990014360A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU659412B2 (en) * 1990-06-25 1995-05-18 Osi Pharmaceuticals, Inc. Tissue-derived tumor growth inhibitors
CZ287715B6 (en) * 1992-02-12 2001-01-17 Bioph Biotech Entw Pharm Gmbh DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use
WO1997039023A1 (en) * 1996-04-12 1997-10-23 Astra Aktiebolag Cysteine-containing or methioine-containing peptides with immunomodulatory effects

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions

Also Published As

Publication number Publication date
AU5729390A (en) 1990-12-18
AU668072B2 (en) 1996-04-26
JPH04505325A (ja) 1992-09-17
EP0508983A4 (en) 1993-05-05
WO1990014360A1 (en) 1990-11-29
EP0508983A1 (en) 1992-10-21

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Legal Events

Date Code Title Description
FZDE Dead