CA2045173A1 - Acetylated heterologous polypeptides - Google Patents

Acetylated heterologous polypeptides

Info

Publication number
CA2045173A1
CA2045173A1 CA002045173A CA2045173A CA2045173A1 CA 2045173 A1 CA2045173 A1 CA 2045173A1 CA 002045173 A CA002045173 A CA 002045173A CA 2045173 A CA2045173 A CA 2045173A CA 2045173 A1 CA2045173 A1 CA 2045173A1
Authority
CA
Canada
Prior art keywords
rbst
somatotropin
replaced
acetylated
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002045173A
Other languages
English (en)
French (fr)
Inventor
David P. Brunner
Robert L. Garlick
Gary C. Harbour
Stephen B. Lyle
John E. Mott
Jules A. Shafer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2045173A1 publication Critical patent/CA2045173A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002045173A 1989-03-15 1990-01-23 Acetylated heterologous polypeptides Abandoned CA2045173A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32390189A 1989-03-15 1989-03-15
US323,901 1989-03-15

Publications (1)

Publication Number Publication Date
CA2045173A1 true CA2045173A1 (en) 1990-09-16

Family

ID=23261207

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002045173A Abandoned CA2045173A1 (en) 1989-03-15 1990-01-23 Acetylated heterologous polypeptides

Country Status (11)

Country Link
EP (2) EP0719792A2 (OSRAM)
JP (1) JPH04504060A (OSRAM)
KR (1) KR920700292A (OSRAM)
AT (1) ATE142270T1 (OSRAM)
AU (1) AU629929B2 (OSRAM)
CA (1) CA2045173A1 (OSRAM)
DE (1) DE69028396T2 (OSRAM)
DK (1) DK0463115T3 (OSRAM)
ES (1) ES2091241T3 (OSRAM)
HU (1) HUT58796A (OSRAM)
WO (1) WO1990010706A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140071A (en) * 1994-01-27 2000-10-31 Somatogen, Inc. Proteins with mutations to decrease N-terminal methylation
US7547529B1 (en) * 2000-05-10 2009-06-16 Asubio Pharma Co., Ltd. Methods for reducing the formation of by-products in the production of recombinant polypeptides

Also Published As

Publication number Publication date
AU5406090A (en) 1990-10-09
JPH04504060A (ja) 1992-07-23
HU903721D0 (en) 1991-12-30
EP0463115A1 (en) 1992-01-02
EP0719792A2 (en) 1996-07-03
EP0463115B1 (en) 1996-09-04
KR920700292A (ko) 1992-02-19
AU629929B2 (en) 1992-10-15
DE69028396T2 (de) 1997-02-13
DE69028396D1 (de) 1996-10-10
HUT58796A (en) 1992-03-30
EP0719792A3 (OSRAM) 1996-07-24
ES2091241T3 (es) 1996-11-01
ATE142270T1 (de) 1996-09-15
WO1990010706A1 (en) 1990-09-20
DK0463115T3 (OSRAM) 1997-02-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued