CA2040855A1 - Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds and process for the preparation thereof - Google Patents

Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds and process for the preparation thereof

Info

Publication number
CA2040855A1
CA2040855A1 CA002040855A CA2040855A CA2040855A1 CA 2040855 A1 CA2040855 A1 CA 2040855A1 CA 002040855 A CA002040855 A CA 002040855A CA 2040855 A CA2040855 A CA 2040855A CA 2040855 A1 CA2040855 A1 CA 2040855A1
Authority
CA
Canada
Prior art keywords
compound
hydroxy
formula
hydrogen
5alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002040855A
Other languages
English (en)
French (fr)
Inventor
John F. Kadow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CA2040855A1 publication Critical patent/CA2040855A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C325/00—Thioaldehydes; Thioketones; Thioquinones; Oxides thereof
    • C07C325/02—Thioketones; Oxides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/06—Cobalt compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/48—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing ten carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002040855A 1990-04-27 1991-04-19 Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds and process for the preparation thereof Abandoned CA2040855A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51538790A 1990-04-27 1990-04-27
US515,387 1990-04-27
US62150390A 1990-11-30 1990-11-30
US621,503 1990-11-30

Publications (1)

Publication Number Publication Date
CA2040855A1 true CA2040855A1 (en) 1991-10-28

Family

ID=27058485

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002040855A Abandoned CA2040855A1 (en) 1990-04-27 1991-04-19 Cytotoxic bicyclo¬7.3.1| tridec-4-ene-2,6-diyne compounds and process for the preparation thereof

Country Status (14)

Country Link
EP (1) EP0454146A1 (en, 2012)
JP (1) JPH04225934A (en, 2012)
KR (1) KR910018349A (en, 2012)
AU (1) AU648073B2 (en, 2012)
CA (1) CA2040855A1 (en, 2012)
FI (1) FI911982L (en, 2012)
HU (2) HU210786B (en, 2012)
IE (1) IE911424A1 (en, 2012)
IL (1) IL97965A0 (en, 2012)
MY (1) MY135674A (en, 2012)
NZ (1) NZ237944A (en, 2012)
PT (1) PT97483A (en, 2012)
TW (1) TW217414B (en, 2012)
YU (1) YU73391A (en, 2012)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198560A (en) * 1990-04-27 1993-03-30 Bristol-Myers Squibb Company Cytotoxic bicyclo[7.3.1]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof

Also Published As

Publication number Publication date
NZ237944A (en) 1992-08-26
KR910018349A (ko) 1991-11-30
EP0454146A1 (en) 1991-10-30
MY135674A (en) 2008-06-30
HU210786B (en) 1995-07-28
YU73391A (sh) 1994-01-20
TW217414B (en, 2012) 1993-12-11
IE911424A1 (en) 1991-11-06
HU911399D0 (en) 1991-10-28
HUT57781A (en) 1991-12-30
IL97965A0 (en) 1992-06-21
AU7628291A (en) 1991-11-07
PT97483A (pt) 1992-01-31
FI911982A7 (fi) 1991-10-28
FI911982A0 (fi) 1991-04-24
AU648073B2 (en) 1994-04-14
HU9401362D0 (en) 1994-08-29
JPH04225934A (ja) 1992-08-14
FI911982L (fi) 1991-10-28

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Legal Events

Date Code Title Description
FZDE Discontinued