CA2038969A1 - Composes contenant un agent cytotoxique et des stimulateurs de la permeation - Google Patents

Composes contenant un agent cytotoxique et des stimulateurs de la permeation

Info

Publication number
CA2038969A1
CA2038969A1 CA002038969A CA2038969A CA2038969A1 CA 2038969 A1 CA2038969 A1 CA 2038969A1 CA 002038969 A CA002038969 A CA 002038969A CA 2038969 A CA2038969 A CA 2038969A CA 2038969 A1 CA2038969 A1 CA 2038969A1
Authority
CA
Canada
Prior art keywords
weight
permeation
present
fluorouracil
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002038969A
Other languages
English (en)
Inventor
Michel J. N. Cormier
Lina T. Taskovich
Su I. Yum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of CA2038969A1 publication Critical patent/CA2038969A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002038969A 1990-03-30 1991-03-25 Composes contenant un agent cytotoxique et des stimulateurs de la permeation Abandoned CA2038969A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50248890A 1990-03-30 1990-03-30
US502,488 1990-03-30

Publications (1)

Publication Number Publication Date
CA2038969A1 true CA2038969A1 (fr) 1991-10-01

Family

ID=23998069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002038969A Abandoned CA2038969A1 (fr) 1990-03-30 1991-03-25 Composes contenant un agent cytotoxique et des stimulateurs de la permeation

Country Status (9)

Country Link
EP (1) EP0522006A1 (fr)
JP (1) JPH05505807A (fr)
AU (1) AU633207B2 (fr)
CA (1) CA2038969A1 (fr)
FI (1) FI924344A (fr)
IE (1) IE910976A1 (fr)
PT (1) PT97139A (fr)
WO (1) WO1991015210A1 (fr)
ZA (1) ZA912228B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958876A (en) * 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
AU753018B2 (en) * 1996-06-19 2002-10-03 Novartis Ag Cyclosporin-containing soft capsule preparations
AU722285B2 (en) * 1996-06-19 2000-07-27 Novartis Ag Cyclosporin-containing soft capsule preparations
SG88752A1 (en) * 1996-06-19 2002-05-21 Novartis Ag Cyclosporin-containing soft capsule preparations
US5993787A (en) * 1996-09-13 1999-11-30 Johnson & Johnson Consumer Products, Inc. Composition base for topical therapeutic and cosmetic preparations
NZ314702A (en) * 1997-04-29 1998-07-28 Bernard Charles Sherman Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent
WO2005079855A1 (fr) * 2004-02-23 2005-09-01 David Quintanar Guerrero Composition activatrice de penetration a base d'esters d'acides gras de saccharose
CN114423431B (zh) 2019-08-14 2024-03-15 纳诺麦缇科斯有限责任公司(经营别称为Phd生物科学) 尿嘧啶皮肤药物制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE37447B1 (en) * 1972-04-05 1977-07-20 Procter & Gamble Dermatological compositions
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4849426A (en) * 1987-05-15 1989-07-18 Pearlman Dale L Method for treating actinic keratosis with cytotoxic agents

Also Published As

Publication number Publication date
EP0522006A1 (fr) 1993-01-13
AU7562091A (en) 1991-10-30
PT97139A (pt) 1991-11-29
JPH05505807A (ja) 1993-08-26
IE910976A1 (en) 1991-10-09
WO1991015210A1 (fr) 1991-10-17
FI924344A0 (fi) 1992-09-28
ZA912228B (en) 1991-12-24
FI924344A (fi) 1992-09-28
AU633207B2 (en) 1993-01-21

Similar Documents

Publication Publication Date Title
CA2309688C (fr) Systeme ameliorant l'administration de medicaments et reduisant les irritations
US4440777A (en) Use of eucalyptol for enhancing skin permeation of bio-affecting agents
CA2135925C (fr) Emploi de la glycerine pour moderer l'administration de medicaments par voie transdermale
CA2033499C (fr) Methode d'administration de l'ibuprofene par voie percutanee dans un gel hydroalcoolique
KR0143916B1 (ko) 약물/침투 증대제 조성물과 관련된 피부자극의 감소방법
US4560553A (en) Use of eucalyptol for enhancing skin permeation of bio-affecting agents
AU633207B2 (en) Compositions comprising cytotoxic agent and permeation enhancers
CA1176167A (fr) Utilisation de n,n-diethyl-m-toluamide pour ameliorer la penetration, par la peau, d'agents bioactifs
US4762851A (en) Pyroglutamic acid esters used as dermal penetration enhancers for drugs
US4847250A (en) Pyroglutamic acid esters used as dermal penetration enhancers for drugs
US4970206A (en) Pyroglutamic acid esters used as dermal penetration enhancers for drugs
JPS60163811A (ja) プロプラノロ−ル含有外用貼付剤
US4888360A (en) Carvone enhancement of transdermal drug delivery
EP1043979B1 (fr) Compositions destinees a l'administration transcutanee et cutanee d'agents biologiquement actifs
JPH01308225A (ja) 外用医薬組成物
US4888362A (en) Eugenol enhancement of transdermal drug delivery
US5183665A (en) Composition for percutaneous administration and method for enhancing percutaneous absorption of a physiologically active ingredient empolying the same
NZ196395A (en) Topical pharmaceutical composition containing n,n-diethyl-m-toluamide
KR20240042065A (ko) 국소 마취제-점토 복합체 조성물
JP2779063B2 (ja) 皮膚刺激緩和組成物及びこれを含有する経皮外用剤
MXPA00004513A (en) Penetration enhancing and irritation reducing systems

Legal Events

Date Code Title Description
FZDE Dead