CA2029678A1 - Isolation et elucidation structurale du dipeptide lineaire cytostatique dolastatine-14 - Google Patents

Isolation et elucidation structurale du dipeptide lineaire cytostatique dolastatine-14

Info

Publication number
CA2029678A1
CA2029678A1 CA2029678A CA2029678A CA2029678A1 CA 2029678 A1 CA2029678 A1 CA 2029678A1 CA 2029678 A CA2029678 A CA 2029678A CA 2029678 A CA2029678 A CA 2029678A CA 2029678 A1 CA2029678 A1 CA 2029678A1
Authority
CA
Canada
Prior art keywords
dolastatin
isolation
depsipeptide
structural elucidation
cytostatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2029678A
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English (en)
Other versions
CA2029678C (fr
Inventor
George R. Pettit
Yoshiaki Kamano
Cherry L. Herald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona Board of Regents of ASU
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Arizona Board of Regents of ASU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Arizona Board of Regents of ASU filed Critical Arizona Board of Regents of ASU
Publication of CA2029678A1 publication Critical patent/CA2029678A1/fr
Application granted granted Critical
Publication of CA2029678C publication Critical patent/CA2029678C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA002029678A 1989-11-13 1990-11-09 Isolation et elucidation structurale du dipeptide lineaire cytostatique dolastatine-14 Expired - Fee Related CA2029678C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/435,622 US5138036A (en) 1989-11-13 1989-11-13 Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
US07/435,622 1989-11-13

Publications (2)

Publication Number Publication Date
CA2029678A1 true CA2029678A1 (fr) 1991-05-14
CA2029678C CA2029678C (fr) 1999-10-26

Family

ID=23729137

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002029678A Expired - Fee Related CA2029678C (fr) 1989-11-13 1990-11-09 Isolation et elucidation structurale du dipeptide lineaire cytostatique dolastatine-14

Country Status (4)

Country Link
US (1) US5138036A (fr)
EP (1) EP0428367A1 (fr)
JP (1) JPH03170499A (fr)
CA (1) CA2029678C (fr)

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US5138036A (en) 1992-08-11

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