CA2022740A1 - Antagonistes cycliques de la neurokinine a - Google Patents

Antagonistes cycliques de la neurokinine a

Info

Publication number
CA2022740A1
CA2022740A1 CA2022740A CA2022740A CA2022740A1 CA 2022740 A1 CA2022740 A1 CA 2022740A1 CA 2022740 A CA2022740 A CA 2022740A CA 2022740 A CA2022740 A CA 2022740A CA 2022740 A1 CA2022740 A1 CA 2022740A1
Authority
CA
Canada
Prior art keywords
neurokinin
antagonists
derivatives
cyclic
cyclic neurokinin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2022740A
Other languages
English (en)
Other versions
CA2022740C (fr
Inventor
Scott L. Harbeson
Stephen H. Buck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Canada Inc
Original Assignee
Merrell Dow Pharmaceuticals Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Canada Inc filed Critical Merrell Dow Pharmaceuticals Canada Inc
Publication of CA2022740A1 publication Critical patent/CA2022740A1/fr
Application granted granted Critical
Publication of CA2022740C publication Critical patent/CA2022740C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002022740A 1989-08-10 1990-08-07 Antagonistes cycliques de la neurokinine a Expired - Lifetime CA2022740C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39223689A 1989-08-10 1989-08-10
US392,236 1989-08-10

Publications (2)

Publication Number Publication Date
CA2022740A1 true CA2022740A1 (fr) 1991-02-11
CA2022740C CA2022740C (fr) 2000-05-02

Family

ID=23549831

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002022740A Expired - Lifetime CA2022740C (fr) 1989-08-10 1990-08-07 Antagonistes cycliques de la neurokinine a

Country Status (22)

Country Link
US (1) US5731286A (fr)
EP (1) EP0412542B1 (fr)
JP (1) JP2829779B2 (fr)
KR (1) KR0169123B1 (fr)
CN (1) CN1035056C (fr)
AR (1) AR246087A1 (fr)
AT (1) ATE132503T1 (fr)
AU (1) AU638264B2 (fr)
CA (1) CA2022740C (fr)
DD (1) DD297168A5 (fr)
DE (1) DE69024555T2 (fr)
DK (1) DK0412542T3 (fr)
ES (1) ES2084627T3 (fr)
FI (1) FI95913C (fr)
GR (1) GR3018984T3 (fr)
HU (1) HU206729B (fr)
IE (1) IE69382B1 (fr)
IL (1) IL95309A (fr)
NO (1) NO177715C (fr)
NZ (1) NZ234814A (fr)
PT (1) PT94952B (fr)
ZA (1) ZA906188B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ229552A (en) * 1988-06-20 1992-06-25 Merrell Dow Pharma Neurokinin a antagonists
DE4034829A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh Cyclopeptide
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5625060A (en) * 1991-05-03 1997-04-29 Elf Sanofi Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
AU2387592A (en) * 1991-08-08 1993-03-02 A. Menarini Industrie Farmaceutiche Riunite S.R.L. Cyclic hexapeptides as tachyquinin antagonists, their preparation and pharmaceutical compositions thereof
US5731285A (en) * 1992-04-15 1998-03-24 A. Menatini Industrie Farmaceutiche Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds
AU2010225426B2 (en) 2009-03-16 2015-09-03 The Governing Council Of The University Of Toronto Cyclic amino acid molecules and methods of preparing the same
CN109071430A (zh) 2015-11-11 2018-12-21 循环治疗学公司 环肽的片段合成
ES2884107T3 (es) 2016-11-11 2021-12-10 Zealand Pharma As Multímeros de péptidos cíclicos con diana en la integrina alfa-4 beta-7
IL270465B (en) 2017-05-10 2022-09-01 Encycle Therapeutics Inc Cyclic peptides targeting alpha4beta7 integrin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4665157A (en) * 1985-09-30 1987-05-12 Mcneilab, Inc. Peptide antagonists of neurokinin B
US4742156A (en) * 1985-09-30 1988-05-03 Mcneilab, Inc. Peptide antagonists of neurokinin B and opthalmic solutions containing them
DE3711335A1 (de) * 1987-04-03 1988-10-20 Merck Patent Gmbh Aminosaeurederivate
GB8807246D0 (en) * 1988-03-25 1988-04-27 Merck Sharp & Dohme Therapeutic agents
NZ229552A (en) * 1988-06-20 1992-06-25 Merrell Dow Pharma Neurokinin a antagonists
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical preparations containing them
FR2677361A1 (fr) * 1991-06-04 1992-12-11 Adir Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU6022290A (en) 1991-05-16
DK0412542T3 (da) 1996-01-29
US5731286A (en) 1998-03-24
NO177715B (no) 1995-07-31
GR3018984T3 (en) 1996-05-31
JPH03141295A (ja) 1991-06-17
ATE132503T1 (de) 1996-01-15
PT94952B (pt) 1997-07-31
FI95913B (fi) 1995-12-29
HUT54713A (en) 1991-03-28
IE69382B1 (en) 1996-09-04
ES2084627T3 (es) 1996-05-16
NZ234814A (en) 1992-03-26
FI903922A0 (fi) 1990-08-08
NO903513D0 (no) 1990-08-09
KR910004665A (ko) 1991-03-29
CN1035056C (zh) 1997-06-04
CA2022740C (fr) 2000-05-02
NO177715C (no) 1995-11-08
PT94952A (pt) 1991-04-18
DD297168A5 (de) 1992-01-02
KR0169123B1 (ko) 1999-01-15
IE902886A1 (en) 1991-02-27
FI95913C (fi) 1996-04-10
CN1049353A (zh) 1991-02-20
IL95309A (en) 1995-07-31
HU904952D0 (en) 1991-01-28
EP0412542B1 (fr) 1996-01-03
DE69024555T2 (de) 1996-05-15
AR246087A1 (es) 1994-03-30
ZA906188B (en) 1991-06-26
DE69024555D1 (de) 1996-02-15
JP2829779B2 (ja) 1998-12-02
AU638264B2 (en) 1993-06-24
HU206729B (en) 1992-12-28
IL95309A0 (en) 1991-06-30
EP0412542A3 (en) 1991-07-24
EP0412542A2 (fr) 1991-02-13
NO903513L (no) 1991-02-11

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Legal Events

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MKEX Expiry

Effective date: 20100807