CA2019095C - Bio-adhesive composition - Google Patents
Bio-adhesive composition Download PDFInfo
- Publication number
- CA2019095C CA2019095C CA002019095A CA2019095A CA2019095C CA 2019095 C CA2019095 C CA 2019095C CA 002019095 A CA002019095 A CA 002019095A CA 2019095 A CA2019095 A CA 2019095A CA 2019095 C CA2019095 C CA 2019095C
- Authority
- CA
- Canada
- Prior art keywords
- sucralfate
- gel
- bio
- sulphate
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000000227 bioadhesive Substances 0.000 title claims abstract description 10
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 claims abstract description 51
- 229960004291 sucralfate Drugs 0.000 claims abstract description 50
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000007787 solid Substances 0.000 claims abstract description 9
- 239000006071 cream Substances 0.000 claims abstract description 7
- 239000002245 particle Substances 0.000 claims abstract description 7
- 239000002537 cosmetic Substances 0.000 claims abstract description 6
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 claims abstract description 6
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 6
- 239000006185 dispersion Substances 0.000 claims abstract description 5
- FXKSEJFHKVNEFI-GCZBSULCSA-N amikacin disulfate Chemical compound [H+].[H+].[H+].[H+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O FXKSEJFHKVNEFI-GCZBSULCSA-N 0.000 claims abstract description 4
- 239000000126 substance Substances 0.000 claims description 9
- 239000003981 vehicle Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 230000003796 beauty Effects 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000007858 starting material Substances 0.000 claims description 2
- 229940099259 vaseline Drugs 0.000 claims description 2
- 239000000499 gel Substances 0.000 description 30
- 238000002360 preparation method Methods 0.000 description 11
- 239000006072 paste Substances 0.000 description 8
- 238000009472 formulation Methods 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 210000004051 gastric juice Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 238000001035 drying Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000007900 aqueous suspension Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000000518 rheometry Methods 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229960004821 amikacin Drugs 0.000 description 2
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 description 2
- 230000035587 bioadhesion Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 159000000013 aluminium salts Chemical class 0.000 description 1
- 229910000329 aluminium sulfate Inorganic materials 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000008135 aqueous vehicle Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20898A/89 | 1989-06-16 | ||
| IT8920898A IT1230157B (it) | 1989-06-16 | 1989-06-16 | Uso di sucralfato gel umido per il trattamento di ulcere del derma e come veicolo di farmaci ad attivita' topica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2019095A1 CA2019095A1 (en) | 1990-12-16 |
| CA2019095C true CA2019095C (en) | 2002-09-17 |
Family
ID=11173752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002019095A Expired - Lifetime CA2019095C (en) | 1989-06-16 | 1990-06-15 | Bio-adhesive composition |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5246697A (de) |
| EP (1) | EP0402933B2 (de) |
| JP (1) | JPH0825908B2 (de) |
| AT (1) | ATE129408T1 (de) |
| CA (1) | CA2019095C (de) |
| DE (1) | DE69023169T3 (de) |
| DK (1) | DK0402933T3 (de) |
| ES (1) | ES2081319T5 (de) |
| GR (2) | GR3018075T3 (de) |
| IT (1) | IT1230157B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994027579A1 (en) * | 1993-05-24 | 1994-12-08 | Ribogene, Inc. | Ulcer treating composition |
| IT1264546B1 (it) * | 1993-07-30 | 1996-10-02 | Lisapharma Spa | Composizione farmaceutica ad attivita' antiacida in forma di sospensione a base di gel di sucralfato |
| US5938693A (en) * | 1995-06-30 | 1999-08-17 | Philips Electronics North America Corporation | Moist heat in vapor form health and beauty therapeutic system |
| US6416779B1 (en) | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
| US6572874B1 (en) | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| US6194455B1 (en) | 1999-05-28 | 2001-02-27 | Marie Madeline Wharton | Topical medicament for treating skin ulcers |
| US6372786B2 (en) | 1999-05-28 | 2002-04-16 | Marie Madeline Wharton | Composition containing sucrafate and a topical anesthetic for humans and animals and method of use thereof |
| DE10032118B9 (de) * | 2000-07-01 | 2006-12-07 | Wella Ag | Antithixotropes kosmetisches Mittel |
| CA2329552C (en) | 2000-12-22 | 2010-04-13 | Bayer Inc. | An improved process for the preparation of butyl rubber utilizing alkylaluminum dihalides and aluminoxanes |
| FR2927808B1 (fr) * | 2008-02-26 | 2011-04-29 | Fabre Pierre Dermo Cosmetique | Gel de sucralfate sterilise |
| US10716802B2 (en) | 2013-03-15 | 2020-07-21 | The Brigham And Women's Hospital, Inc. | Compounds to modulate intestinal absorption of nutrients |
| EP3352738B1 (de) | 2015-09-24 | 2024-01-17 | The Brigham and Women's Hospital, Inc. | Wasseraktivierte mukoadhäsive zusammensetzungen zur verringerung der intestinalen absorption von nährstoffen |
| CN109431972B (zh) * | 2018-11-20 | 2022-02-22 | 昆明积大制药股份有限公司 | 一种粒径为100nm—500nm的硫糖铝凝胶的成胶方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59107209A (ja) * | 1982-12-13 | 1984-06-21 | Oval Eng Co Ltd | 渦流量計用ピツクアツプ |
| DE3322078A1 (de) * | 1983-06-20 | 1984-12-20 | Merck Patent Gmbh, 6100 Darmstadt | Verwendung von sucralfat zur bekaempfung von emesis und/oder diarrhoe |
| IT1212778B (it) * | 1983-10-07 | 1989-11-30 | Lisapharma Spa | Composizioni farmaceutiche adattivita' antiinfiammatoria e/o analgesica, non ulcerogene. |
| US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
| DE3681754D1 (de) * | 1985-04-27 | 1991-11-07 | Nitto Denko Corp | Klebepflaster und arzneimittel fuer die mundhoehle. |
| IT1215332B (it) * | 1987-01-12 | 1990-02-08 | Crinos Industria Farmaco | Composizione farmaceutica contenente sulglicotide per la terapia dell'ulcera gastrica |
| IT1203901B (it) * | 1987-04-15 | 1989-02-23 | Lisapharma Spa | Composizioni farmaceutiche sotto forma di sospensioni stabili di sucralfato esenti da agenti sospendenti |
| US4853227A (en) * | 1987-10-23 | 1989-08-01 | Ciba-Geigy Corporation | Transdermal administration of a systemic active agent to a premature neonatal infant |
| DK505488D0 (da) * | 1987-12-21 | 1988-09-09 | Bar Shalom Daniel | Middel og anvendelse af samme |
| US4910023A (en) * | 1988-06-09 | 1990-03-20 | Warner-Lambert Company | Drug in combination with flavor masking agent and method for making same |
| FR2646604B1 (fr) * | 1989-05-03 | 1994-02-04 | Fabre Medicament Pierre | Composition pour usage externe a base de sucralfate et son procede de preparation |
| EP0403048A3 (de) * | 1989-06-14 | 1991-01-30 | Warner-Lambert Company | Medizinische Sucralfat enthaltende Zusammensetzungen und Verfahren zur Herstellung |
-
1989
- 1989-06-16 IT IT8920898A patent/IT1230157B/it active
-
1990
- 1990-06-14 JP JP2154119A patent/JPH0825908B2/ja not_active Expired - Lifetime
- 1990-06-15 ES ES90111329T patent/ES2081319T5/es not_active Expired - Lifetime
- 1990-06-15 CA CA002019095A patent/CA2019095C/en not_active Expired - Lifetime
- 1990-06-15 EP EP90111329A patent/EP0402933B2/de not_active Expired - Lifetime
- 1990-06-15 DK DK90111329.0T patent/DK0402933T3/da active
- 1990-06-15 DE DE69023169T patent/DE69023169T3/de not_active Expired - Lifetime
- 1990-06-15 US US07/538,739 patent/US5246697A/en not_active Expired - Lifetime
- 1990-06-15 AT AT90111329T patent/ATE129408T1/de not_active IP Right Cessation
-
1995
- 1995-11-13 GR GR950403193T patent/GR3018075T3/el unknown
-
1999
- 1999-12-29 GR GR990403366T patent/GR3032278T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5246697A (en) | 1993-09-21 |
| GR3018075T3 (en) | 1996-02-29 |
| JPH0395106A (ja) | 1991-04-19 |
| IT1230157B (it) | 1991-10-14 |
| IT8920898A0 (it) | 1989-06-16 |
| GR3032278T3 (en) | 2000-04-27 |
| DE69023169T3 (de) | 2000-04-20 |
| EP0402933B1 (de) | 1995-10-25 |
| DK0402933T3 (da) | 1995-12-04 |
| ATE129408T1 (de) | 1995-11-15 |
| DE69023169T2 (de) | 1996-04-18 |
| DE69023169D1 (de) | 1995-11-30 |
| JPH0825908B2 (ja) | 1996-03-13 |
| EP0402933A3 (de) | 1992-09-30 |
| ES2081319T3 (es) | 1996-03-01 |
| EP0402933B2 (de) | 1999-12-15 |
| EP0402933A2 (de) | 1990-12-19 |
| CA2019095A1 (en) | 1990-12-16 |
| ES2081319T5 (es) | 2000-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |