CA1341503C - Clonage moleculaire et expression d'interleukine-3 humaine - Google Patents
Clonage moleculaire et expression d'interleukine-3 humaine Download PDFInfo
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- CA1341503C CA1341503C CA000554561A CA554561A CA1341503C CA 1341503 C CA1341503 C CA 1341503C CA 000554561 A CA000554561 A CA 000554561A CA 554561 A CA554561 A CA 554561A CA 1341503 C CA1341503 C CA 1341503C
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- HTSYYNWISWGUIR-UHFFFAOYSA-N neoline Natural products CCN1CC2(COc3ccccc3)CCC(O)C45C6CC7C(CC(O)(C6C7O)C(C(OC)C24)C15)OC HTSYYNWISWGUIR-UHFFFAOYSA-N 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
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- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP86202285.2 | 1986-12-16 | ||
| EP86202285 | 1986-12-16 | ||
| EP87201322.2 | 1987-07-13 | ||
| EP87201322 | 1987-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1341503C true CA1341503C (fr) | 2006-04-04 |
Family
ID=26103432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000554561A Expired - Fee Related CA1341503C (fr) | 1986-12-16 | 1997-12-16 | Clonage moleculaire et expression d'interleukine-3 humaine |
Country Status (14)
| Country | Link |
|---|---|
| JP (2) | JPH01502157A (fr) |
| AT (1) | ATE161882T1 (fr) |
| AU (1) | AU617095B2 (fr) |
| CA (1) | CA1341503C (fr) |
| DE (1) | DE3752158T2 (fr) |
| ES (1) | ES2113338T3 (fr) |
| FI (1) | FI102293B1 (fr) |
| GR (1) | GR3025857T3 (fr) |
| IE (1) | IE81129B1 (fr) |
| IL (1) | IL84852A (fr) |
| NO (1) | NO180544C (fr) |
| NZ (1) | NZ222939A (fr) |
| PT (1) | PT86381B (fr) |
| WO (1) | WO1988004691A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR871029B (en) * | 1986-07-14 | 1987-11-02 | Genetics Inst | Novel osteoinductive factors |
| US6238889B1 (en) | 1986-12-16 | 2001-05-29 | Dsm N.V. | Molecular cloning and expression of the Pro8 isoform of human IL-3 |
| OA09736A (en) * | 1987-02-18 | 1993-11-30 | Schering Biotech Corp | "Human interleukin-3 and muteins thereof". |
| US5304637A (en) * | 1987-07-13 | 1994-04-19 | Gist-Brocades N.V. | Expression and purification of human interleukin-3 and muteins thereof |
| GB2210883B (en) * | 1987-10-08 | 1992-01-02 | British Bio Technology | Synthetic interleukin-3 gene |
| US6384194B1 (en) | 1987-12-16 | 2002-05-07 | Dsm N.V. | Expression and purification of human interleukin-3 and muteins thereof |
| JPH04500508A (ja) * | 1988-07-20 | 1992-01-30 | イミュネックス・コーポレーション | 非グリコシル化 ヒト インターロイキン―３ 組成物 |
| NZ232913A (en) * | 1989-03-15 | 1992-08-26 | Gist Brocades Nv | Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations |
| US5128450A (en) * | 1989-06-30 | 1992-07-07 | Urdal David L | Nonglycosylated human interleukin-3 analog proteins |
| DE69030937T2 (de) | 1989-08-14 | 1997-10-09 | Gist Brocades Nv | Mutanten von Interleukin-3 |
| US5516512A (en) | 1989-08-14 | 1996-05-14 | Gist-Brocades, N.V. | N- and C-terminal truncation and deletion mutants of human interleukin-3 |
| ATE150486T1 (de) * | 1991-08-01 | 1997-04-15 | Fond Nat Transfusion Sanguine | Expression in nicht-tumorbildenden menschlichen lymphoblasten zellinien mit einem integrierenden vektor |
| WO1994012639A2 (fr) * | 1992-11-24 | 1994-06-09 | G. D. Searle & Co. | Polypeptides mutants d'interleukine-3 |
| US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US5501962A (en) * | 1993-06-21 | 1996-03-26 | G. D. Searle & Co. | Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same |
| US6017523A (en) * | 1995-06-06 | 2000-01-25 | G.D. Searle & Co. | Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides |
| AU2866599A (en) * | 1998-02-17 | 1999-08-30 | Hyseq, Inc. | A novel interleukin-3 and uses thereof |
| CA2595679A1 (fr) * | 2005-01-25 | 2006-08-03 | Apollo Life Sciences Limited | Gm-csf, il-3, il-4, il-5 choisis en fonction de parametres et leurs chimeres dans des applications therapeutiques et diagnostiques |
| JP2009532061A (ja) * | 2006-04-03 | 2009-09-10 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | 組換えウシ血清アルブミン（ｒＢＳＡ）の発現、分泌及び精製、並びにその使用 |
| JP2025530648A (ja) | 2022-08-11 | 2025-09-17 | ウニヴェルズィテーツクリニクム レーゲンスブルク | Ｉｌ３を標的とする抗体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695542A (en) * | 1983-10-04 | 1987-09-22 | Dnax Research Institute Of Molecular And Cellular Biology, Inc. | cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity |
| AU570762B2 (en) * | 1983-12-23 | 1988-03-24 | Australian National University, The | Cloning of cdna for il-3 |
| GR871029B (en) * | 1986-07-14 | 1987-11-02 | Genetics Inst | Novel osteoinductive factors |
-
1987
- 1987-12-16 AT AT87202566T patent/ATE161882T1/de not_active IP Right Cessation
- 1987-12-16 AU AU10577/88A patent/AU617095B2/en not_active Ceased
- 1987-12-16 DE DE3752158T patent/DE3752158T2/de not_active Expired - Fee Related
- 1987-12-16 IE IE340987A patent/IE81129B1/en not_active IP Right Cessation
- 1987-12-16 ES ES87202566T patent/ES2113338T3/es not_active Expired - Lifetime
- 1987-12-16 JP JP63500606A patent/JPH01502157A/ja active Pending
- 1987-12-16 NZ NZ222939A patent/NZ222939A/en unknown
- 1987-12-16 IL IL8485287A patent/IL84852A/en not_active IP Right Cessation
- 1987-12-16 WO PCT/NL1987/000037 patent/WO1988004691A1/fr not_active Ceased
- 1987-12-16 PT PT86381A patent/PT86381B/pt not_active IP Right Cessation
-
1988
- 1988-08-08 FI FI883688A patent/FI102293B1/fi not_active IP Right Cessation
- 1988-08-12 NO NO883614A patent/NO180544C/no not_active IP Right Cessation
-
1997
- 1997-05-28 JP JP9154513A patent/JPH1080286A/ja active Pending
- 1997-12-16 CA CA000554561A patent/CA1341503C/fr not_active Expired - Fee Related
-
1998
- 1998-01-08 GR GR980400027T patent/GR3025857T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO883614D0 (no) | 1988-08-12 |
| FI102293B (fi) | 1998-11-13 |
| FI102293B1 (fi) | 1998-11-13 |
| FI883688L (fi) | 1988-08-08 |
| IL84852A0 (en) | 1988-06-30 |
| GR3025857T3 (en) | 1998-04-30 |
| JPH01502157A (ja) | 1989-08-03 |
| NZ222939A (en) | 1991-03-26 |
| NO883614L (no) | 1988-08-12 |
| IE81129B1 (en) | 2000-03-22 |
| FI883688A0 (fi) | 1988-08-08 |
| ES2113338T3 (es) | 1998-05-01 |
| JPH1080286A (ja) | 1998-03-31 |
| IE873409L (en) | 1988-06-12 |
| PT86381A (en) | 1988-01-01 |
| NO180544C (no) | 1997-05-07 |
| WO1988004691A1 (fr) | 1988-06-30 |
| ATE161882T1 (de) | 1998-01-15 |
| AU1057788A (en) | 1988-07-15 |
| DE3752158D1 (de) | 1998-02-12 |
| NO180544B (no) | 1997-01-27 |
| AU617095B2 (en) | 1991-11-21 |
| PT86381B (pt) | 1990-11-20 |
| DE3752158T2 (de) | 1998-05-20 |
| IL84852A (en) | 1994-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20090406 |