CA1341199C - Method for obtaining a vaccine with wide protective range against group b neisseria meningitidis, the resulting vaccine, gammaglobulin and transfer factor - Google Patents

Method for obtaining a vaccine with wide protective range against group b neisseria meningitidis, the resulting vaccine, gammaglobulin and transfer factor Download PDF

Info

Publication number
CA1341199C
CA1341199C CA000573538A CA573538A CA1341199C CA 1341199 C CA1341199 C CA 1341199C CA 000573538 A CA000573538 A CA 000573538A CA 573538 A CA573538 A CA 573538A CA 1341199 C CA1341199 C CA 1341199C
Authority
CA
Canada
Prior art keywords
vaccine
group
complex
protein
purified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000573538A
Other languages
English (en)
French (fr)
Inventor
Concepcion Campa Huergo
Victoriano Gustavo Sierra Gonzalez
Maria Mercedes Gutierrez Vazquez
Gonzalo Bisset Jorrin
Luis Guillermo Garcia Imia
Gisela De La Caridad Puentes Rizo
Maria Del Carmen Sampedro Herrera
Franklin Sotolongo Padron
Eloisa Xochitl Le Riverend Morales
Manuel Alfredo Galguera Dominguez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INSTITUTO FINLAY
Original Assignee
INSTITUTO FINLAY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INSTITUTO FINLAY filed Critical INSTITUTO FINLAY
Application granted granted Critical
Publication of CA1341199C publication Critical patent/CA1341199C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA000573538A 1987-07-30 1988-08-01 Method for obtaining a vaccine with wide protective range against group b neisseria meningitidis, the resulting vaccine, gammaglobulin and transfer factor Expired - Fee Related CA1341199C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU125/87 1987-07-30
CU1987125 1987-07-30

Publications (1)

Publication Number Publication Date
CA1341199C true CA1341199C (en) 2001-03-06

Family

ID=5459411

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000573538A Expired - Fee Related CA1341199C (en) 1987-07-30 1988-08-01 Method for obtaining a vaccine with wide protective range against group b neisseria meningitidis, the resulting vaccine, gammaglobulin and transfer factor

Country Status (11)

Country Link
US (2) US5597572A (instruction)
EP (1) EP0301992B1 (instruction)
JP (1) JPH01125328A (instruction)
AT (1) ATE122893T1 (instruction)
AU (3) AU615461B2 (instruction)
CA (1) CA1341199C (instruction)
DE (1) DE3853854T2 (instruction)
ES (1) ES2074445T3 (instruction)
GR (1) GR3017218T3 (instruction)
IN (1) IN167607B (instruction)
RU (1) RU2023448C1 (instruction)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118757B1 (en) 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
ES2070312T5 (es) * 1988-12-19 2003-05-16 American Cyanamid Co Vacuna de proteina de membrana exterior meningococica de clase 1.
CU22302A1 (es) * 1990-09-07 1995-01-31 Cigb Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales
DE69423383T2 (de) 1993-05-13 2000-08-24 American Cyanamid Co., Wayne Herstellung und Verwendungen von LOS-verminderten Aussenmembran-Proteinen von Gram-negativen Kokken
US6287574B1 (en) 1995-03-17 2001-09-11 Biochem Pharma Inc. Proteinase K resistant surface protein of neisseria meningitidis
KR19990045763A (ko) * 1995-09-18 1999-06-25 유나이티드 스테이트 아미 메디칼 리서치 머티어리얼커맨드 (유에스에이엠알엠씨) 비공유결합성으로 착염화된 다가의 프로테오좀 서브-유니트 백신의 개선된 제조 방법
FR2751000B1 (fr) * 1996-07-12 1998-10-30 Inst Nat Sante Rech Med Adn specifiques des bacteries de l'espece neisseria meningitidis, leurs procedes d'obtention et leurs applications biologiques
US6558677B2 (en) * 1996-10-15 2003-05-06 Wendell D. Zollinger Vaccine against gram negative bacteria
RU2347813C2 (ru) * 1997-11-06 2009-02-27 Чирон С.П.А. Антигены нейссерий
GB9726398D0 (en) 1997-12-12 1998-02-11 Isis Innovation Polypeptide and coding sequences
GB9808734D0 (en) * 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
GB9808866D0 (en) * 1998-04-24 1998-06-24 Smithkline Beecham Biolog Novel compounds
GB9810276D0 (en) * 1998-05-13 1998-07-15 Smithkline Beecham Biolog Novel compounds
GB9811260D0 (en) * 1998-05-26 1998-07-22 Smithkline Beecham Biolog Novel compounds
US10967045B2 (en) 1998-11-02 2021-04-06 Secretary of State for Health and Social Care Multicomponent meningococcal vaccine
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
AU2439300A (en) * 1999-01-22 2000-08-07 Smithkline Beecham Biologicals (Sa) Basb055 polynucleotide and polypeptide from neisseria meningitidis. uses thereof
NZ545647A (en) 1999-05-19 2008-02-29 Chiron Srl Combination neisserial compositions
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9929923D0 (en) * 1999-12-17 2000-02-09 Baldwin Thomas J Antigen preparations
CA2416137C (en) * 2000-07-27 2013-01-29 Dan Granoff Vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
RU2322451C2 (ru) * 2001-04-17 2008-04-20 Новартис Вэксинс Энд Диагностикс, Инк. Молекулярные миметики эпитопов менингококка в, которые вызывают выработку функционально активных антител
RU2355704C2 (ru) * 2001-04-17 2009-05-20 Новартис Вэксинс Энд Диагностикс, Инк Моноклональное антитело, направленное против gna33 пептида, и его применение
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
IL145926A0 (en) * 2001-10-15 2002-07-25 Mor Research Applic Ltd Peptide epitopes of mimotopes useful in immunomodulation
CU22983A1 (es) * 2002-05-08 2004-09-09 Inst Finlay Composición vacunal contra las alergias y método para su obtención y empleo en el tratamiento de las mismas
WO2004011027A1 (en) * 2002-07-30 2004-02-05 Baxter International Inc. Chimeric multivalent polysaccharide conjugate vaccines
NZ574530A (en) 2002-08-02 2010-12-24 Glaxosmithkline Biolog Sa Vaccine compositions comprising L2 and/or L3 immunotype lipooligosaccharides from lgtB-neisseria minigitidis
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
PT2279746E (pt) 2002-11-15 2013-12-09 Novartis Vaccines & Diagnostic Proteínas de superfície de neisseria meningitidis
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
CU23313A1 (es) 2002-11-27 2008-09-25 Inst Finlay Ct De Investigacia Mã0/00todo de obtenciã"n de estructuras cocleares. composiciones vacunales y adyuvantes basados en estructuras cocleares y sus intermediarios
PT2191844E (pt) 2003-01-30 2014-06-04 Novartis Ag Vacinas injetáveis contra múltiplos serogrupos meningocócicos
US20040241190A1 (en) * 2003-04-07 2004-12-02 Xenova Research Limited Vaccine preparations
RU2250113C2 (ru) * 2003-06-04 2005-04-20 Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук Способ приготовления бивалентной вакцины для профилактики менингококковой инфекции
GB0316560D0 (en) * 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
GB0323103D0 (en) 2003-10-02 2003-11-05 Chiron Srl De-acetylated saccharides
CU23420A1 (es) * 2003-12-30 2009-09-08 Univ De Cambridge Proteoliposomas y sus derivados como adyuvantes inductores de respuesta citotóxica y las formulaciones resultantes
GB0406013D0 (en) 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0411387D0 (en) 2004-05-21 2004-06-23 Chiron Srl Analysis of saccharide length
GB0413868D0 (en) 2004-06-21 2004-07-21 Chiron Srl Dimensional anlaysis of saccharide conjugates
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
RU2432962C2 (ru) 2005-01-27 2011-11-10 Чилдрен'З Хоспитал Энд Рисерч Сентер Эт Окленд Вакцины с использованием везикул на основе gna 1870 широкого спектра действия для профилактики заболеваний, вызываемых neisseria meningitidis
AU2006263936B2 (en) 2005-06-27 2010-05-20 Glaxosmithkline Biologicals S.A. Immunogenic composition
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
GB0605757D0 (en) 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
US7943352B2 (en) 2006-03-29 2011-05-17 Bacoustics, Llc Apparatus and methods for vaccine development using ultrasound technology
EP2007427A4 (en) 2006-04-11 2012-04-04 Yeda Res & Dev IMPROVED VACCINES WITH MULTIMETER HSP60 PEPTIDE SUPPORTS
US20100068229A1 (en) * 2007-02-07 2010-03-18 Nicola Gargano Recombinant antigens of human cytomegalovirus (hcmv)
US9579372B2 (en) 2008-02-21 2017-02-28 Glaxosmithkline Biologicals Sa Meningococcal fHBP polypeptides
CU20080215A7 (es) 2008-11-19 2012-06-21 Inst Finlay Vacunas unitemporales
CA2772104A1 (en) 2009-08-27 2011-03-03 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences
AU2010310985B2 (en) 2009-10-27 2014-11-06 Glaxosmithkline Biologicals S.A. Modified meningococcal fHBP polypeptides
CA2792687A1 (en) 2010-03-10 2011-09-15 Glaxosmithkline Biologicals S.A. Immunogenic composition
CU20100083A7 (es) 2010-05-05 2012-06-21 Inst Finlay Tolerogenos adyuvados como vacuna de malaria
WO2012025873A2 (en) 2010-08-23 2012-03-01 Wyeth Llc STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENS
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
KR101584871B1 (ko) 2010-09-10 2016-01-22 와이어쓰 엘엘씨 네이세리아 메닝기티디스 orf2086 항원의 비-지질화된 변이체
CU20110202A7 (es) 2011-11-02 2013-12-27 Inst Finlay Ct De Investigación Producción De Sueros Y Vacunas Composición inmunogénica de polisacáridos planos adyuvados y las formulaciones resultantes
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
NZ628449A (en) 2012-03-09 2016-04-29 Pfizer Neisseria meningitidis compositions and methods thereof
EP2689775A1 (en) 2012-07-25 2014-01-29 Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros Cochleate with only one mamp
JP6446377B2 (ja) 2013-03-08 2018-12-26 ファイザー・インク 免疫原性融合ポリペプチド
BR112016004463A2 (pt) 2013-09-08 2017-10-17 Pfizer composições de neisseria meningitidis e métodos das mesmas
KR20160127104A (ko) 2014-02-28 2016-11-02 글락소스미스클라인 바이오로지칼즈 에스.에이. 변형된 수막구균 fhbp 폴리펩티드
US10888611B2 (en) 2015-02-19 2021-01-12 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN118021947A (zh) 2017-01-31 2024-05-14 辉瑞大药厂 脑膜炎奈瑟菌组合物及其使用方法
RU2659948C1 (ru) * 2017-03-14 2018-07-04 Федеральное государственное бюджетное научноеучреждение "Омский аграрный научный центр" (ФГБНУ "Омский АНЦ") Способ получения R-бруцеллёзной сыворотки на кроликах
CN110157767A (zh) * 2019-04-18 2019-08-23 金花企业(集团)股份有限公司 一种转移因子口服溶液生物活性测定方法
CN115605222A (zh) 2019-09-27 2023-01-13 辉瑞公司(Us) 脑膜炎奈瑟氏菌组合物及其方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271147A (en) * 1980-01-10 1981-06-02 Behringwerke Aktiengesellschaft Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same
US4386066A (en) * 1981-08-20 1983-05-31 Merck & Co., Inc. Immunogenic complex from N. gonorrhoeae
US4451446A (en) * 1982-03-04 1984-05-29 Smithkline-Rit Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them
US4885005A (en) * 1982-11-12 1989-12-05 Baxter International Inc. Surfactant treatment of implantable biological tissue to inhibit calcification
EP0109688A3 (en) * 1982-11-23 1986-12-03 The Wellcome Foundation Limited Improved complexes, processes for obtaining them and formulations containing such complexes
US4505853A (en) * 1983-11-18 1985-03-19 Ortho Pharmaceutical Corporation Enzyme-resistant immunomodulatory peptides
US4547489A (en) * 1984-06-11 1985-10-15 Ortho Pharmaceutical Corporation Conformationally restricted thymopentin-like compounds
US4629723A (en) * 1984-06-27 1986-12-16 Ortho Pharmaceutical Corporation Potent thymopentin analogs
US4601903A (en) * 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
US4838888A (en) * 1987-04-17 1989-06-13 Baxter Travenol Laboratories, Inc. Calcification mitigation of implantable bioprostheses

Also Published As

Publication number Publication date
US5597572A (en) 1997-01-28
DE3853854D1 (de) 1995-06-29
DE3853854T2 (de) 1996-02-08
AU2031288A (en) 1989-05-25
US5747653A (en) 1998-05-05
JPH01125328A (ja) 1989-05-17
ATE122893T1 (de) 1995-06-15
EP0301992B1 (en) 1995-05-24
AU5319794A (en) 1994-03-24
EP0301992A3 (en) 1990-02-14
AU8134991A (en) 1991-10-31
AU615461B2 (en) 1991-10-03
IN167607B (instruction) 1990-11-24
EP0301992A2 (en) 1989-02-01
GR3017218T3 (en) 1995-11-30
RU2023448C1 (ru) 1994-11-30
ES2074445T3 (es) 1995-09-16

Similar Documents

Publication Publication Date Title
CA1341199C (en) Method for obtaining a vaccine with wide protective range against group b neisseria meningitidis, the resulting vaccine, gammaglobulin and transfer factor
EP0753310B1 (en) Legionellosis vaccines and methods for their production
Beachey et al. Human immune response to immunization with a structurally defined polypeptide fragment of streptococcal M protein.
Stoll et al. Local and systemic antibody responses to naturally acquired enterotoxigenic Escherichia coli diarrhea in an endemic area
Stephens et al. Pili of Neisseria meningitidis. Analysis of structure and investigation of structural and antigenic relationships to gonococcal pili.
Garner et al. Immunogenic properties of Pseudomonas aeruginosa mucoid exopolysaccharide
Pichichero et al. Acellular pertussis vaccine: immunogenicity and safety of an acellular pertussisvs. a whole cell pertussis vaccine combined with diphtheria and tetanus toxoids as a booster in 18-to 24-month old children
US4203971A (en) Neisseria gonorrhoeae vaccine
Loeb et al. Human antibody response to individual outer membrane proteins of Haemophilus influenzae type b
DK173361B1 (da) Isoleret proteinholdigt materiale, dræbte hele celler af Pasteurella hæmolytica, vaccine mod Pasteurella og fremgangsmåde t
US4239749A (en) Neisseria gonorrhoeae vaccine
Blanco et al. The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum.
Akkoyunlu et al. The acylated form of protein D of Haemophilus influenzae is more immunogenic than the nonacylated form and elicits an adjuvant effect when it is used as a carrier conjugated to polyribosyl ribitol phosphate
Apicella Identification of a subgroup antigen on the Neisseria meningitidis group C capsular polysaccharide
AU706213B2 (en) Method for obtaining a vaccine with wide protective range against group B Neisseria Meningitidis, the resulting vaccine, gammaglobulin and transfer factor
Munoz I. IMMUNOLOGICAL AND OTHER BIOLOGICAL ACTIVITIES OF BORDETELLA PERTUSSIS ANTIGENS
NO179998B (no) Fremgangsmåte for fremstilling av en vaksine mot de forskjellige patogene serotyper av gruppe B Neisseria meningitidis
Kumar et al. Immunogenicity and protective role of an IgA reactive 31-kDa antigen of Vibrio cholerae O139
US4539201A (en) Medicament and method for inducing immunity to infectious bovine keratoconjunctivitis
Saunders et al. Humoral response of the mouse to Treponema pallidum.
Griffiths et al. Developments in pertussis vaccines: memorandum from a WHO meeting
Gotschlich Immune response to the meningococcal group-specific polysaccharides
MUNOZ SYMPOSIUM ON RELATIONSHIP OF STRUCTURE OF MICROORGANISMS TO THEIR IM1IIUNOLOGICAL PROPERTIES'I. IMMUNOLOGICAL AND OTHER BIOLOGICAL ACTIVITIES OF BORDETELLA PERTUSSIS ANTIGENS
Wessman et al. Immune response in swine given soluble antigens from group E Streptococcus
Bhatnagar et al. Proteins from salmonella R-mutants mediating protection against Salmonella typhimurium infection in mice III. Separation and purification of soluble proteins and their use as vaccines and as precipitating antigens

Legal Events

Date Code Title Description
MKLA Lapsed

Effective date: 20160307