CA1334201C - Cardiotonic alkanoyl and aroyl oxazolones - Google Patents
Cardiotonic alkanoyl and aroyl oxazolonesInfo
- Publication number
- CA1334201C CA1334201C CA000591184A CA591184A CA1334201C CA 1334201 C CA1334201 C CA 1334201C CA 000591184 A CA000591184 A CA 000591184A CA 591184 A CA591184 A CA 591184A CA 1334201 C CA1334201 C CA 1334201C
- Authority
- CA
- Canada
- Prior art keywords
- group
- alkyl
- alkoxy
- compound
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/157,430 US4866182A (en) | 1988-02-18 | 1988-02-18 | Cardiotonic alkanoyl and aroyl oxazolones |
| US157,430 | 1988-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1334201C true CA1334201C (en) | 1995-01-31 |
Family
ID=22563682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000591184A Expired - Fee Related CA1334201C (en) | 1988-02-18 | 1989-02-15 | Cardiotonic alkanoyl and aroyl oxazolones |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4866182A (zh) |
| EP (1) | EP0329070B1 (zh) |
| JP (1) | JP2811577B2 (zh) |
| KR (1) | KR960014794B1 (zh) |
| CN (1) | CN1022035C (zh) |
| AT (1) | ATE99681T1 (zh) |
| AU (1) | AU614029B2 (zh) |
| CA (1) | CA1334201C (zh) |
| DE (1) | DE68911944T2 (zh) |
| DK (1) | DK74889A (zh) |
| ES (1) | ES2061748T3 (zh) |
| FI (1) | FI890694A (zh) |
| HU (1) | HU206880B (zh) |
| IL (1) | IL89302A (zh) |
| NO (1) | NO890681L (zh) |
| NZ (1) | NZ227977A (zh) |
| PH (1) | PH26260A (zh) |
| PT (1) | PT89749B (zh) |
| ZA (1) | ZA891111B (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5437491A (en) * | 1994-04-07 | 1995-08-01 | Illinois Tool Works Inc. | Fuel door housing |
| DE4429461A1 (de) * | 1994-08-19 | 1996-02-22 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| ES2125161B1 (es) | 1996-03-21 | 1999-11-16 | Grupo Farmaceutico Almirall S | Nuevos derivados de 2-(3h)-oxazolona. |
| CN102993075A (zh) * | 2012-11-29 | 2013-03-27 | 江苏长青农化股份有限公司 | 硫脲类杀虫杀螨剂丁醚脲的合成工艺 |
| NZ738563A (en) | 2015-06-03 | 2019-09-27 | Bristol Myers Squibb Co | 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3514465A (en) * | 1966-12-30 | 1970-05-26 | Degussa | Certain thiazolyl- and pyridinylaminoketones |
| US4303439A (en) * | 1979-10-01 | 1981-12-01 | Monsanto Company | 2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acids as safening agents |
| JPS59100977A (ja) * | 1982-12-01 | 1984-06-11 | Omron Tateisi Electronics Co | 記録情報出力方法 |
| DE3246957A1 (de) * | 1982-12-18 | 1984-06-20 | Varta Batterie Ag, 3000 Hannover | Galvanisches element |
| EP0114263B1 (de) * | 1982-12-18 | 1987-03-11 | Hans Rinninger u. Sohn GmbH u. Co. | Pflasterstein |
| US4623651A (en) * | 1985-10-15 | 1986-11-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones |
| US4762849A (en) * | 1985-10-15 | 1988-08-09 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic alkanoylthiazolones |
| CA1266268C (en) * | 1985-10-15 | 1990-02-27 | CARDIOTONIC AROYLTHIAZOLONES | |
| US4670450A (en) * | 1985-11-13 | 1987-06-02 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic thiazolones |
| US4728661A (en) * | 1985-11-13 | 1988-03-01 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic phenyl oxazolones |
| US4689353A (en) * | 1986-02-21 | 1987-08-25 | The Dow Chemical Company | Hydroxy and amino-functional polyahls containing carbonate, urethane and/or urea moieties |
-
1988
- 1988-02-18 US US07/157,430 patent/US4866182A/en not_active Expired - Lifetime
-
1989
- 1989-02-13 ZA ZA891111A patent/ZA891111B/xx unknown
- 1989-02-13 AU AU29906/89A patent/AU614029B2/en not_active Ceased
- 1989-02-14 DE DE68911944T patent/DE68911944T2/de not_active Expired - Fee Related
- 1989-02-14 AT AT89102496T patent/ATE99681T1/de not_active IP Right Cessation
- 1989-02-14 EP EP89102496A patent/EP0329070B1/en not_active Expired - Lifetime
- 1989-02-14 FI FI890694A patent/FI890694A/fi not_active Application Discontinuation
- 1989-02-14 ES ES89102496T patent/ES2061748T3/es not_active Expired - Lifetime
- 1989-02-14 NZ NZ227977A patent/NZ227977A/xx unknown
- 1989-02-15 IL IL89302A patent/IL89302A/xx not_active IP Right Cessation
- 1989-02-15 CA CA000591184A patent/CA1334201C/en not_active Expired - Fee Related
- 1989-02-15 PH PH38196A patent/PH26260A/en unknown
- 1989-02-16 JP JP1035200A patent/JP2811577B2/ja not_active Expired - Fee Related
- 1989-02-16 HU HU89778A patent/HU206880B/hu not_active IP Right Cessation
- 1989-02-17 DK DK074889A patent/DK74889A/da not_active Application Discontinuation
- 1989-02-17 PT PT89749A patent/PT89749B/pt not_active IP Right Cessation
- 1989-02-17 KR KR89001825A patent/KR960014794B1/ko not_active IP Right Cessation
- 1989-02-17 NO NO89890681A patent/NO890681L/no unknown
- 1989-02-18 CN CN89102012A patent/CN1022035C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR890012983A (ko) | 1989-09-20 |
| HU206880B (en) | 1993-01-28 |
| ES2061748T3 (es) | 1994-12-16 |
| PH26260A (en) | 1992-04-01 |
| PT89749B (pt) | 1994-03-31 |
| PT89749A (pt) | 1989-10-04 |
| CN1022035C (zh) | 1993-09-08 |
| AU614029B2 (en) | 1991-08-15 |
| ZA891111B (en) | 1989-10-25 |
| ATE99681T1 (de) | 1994-01-15 |
| DE68911944D1 (de) | 1994-02-17 |
| FI890694A (fi) | 1989-08-19 |
| EP0329070A1 (en) | 1989-08-23 |
| NO890681D0 (no) | 1989-02-17 |
| IL89302A0 (en) | 1989-09-10 |
| US4866182A (en) | 1989-09-12 |
| JP2811577B2 (ja) | 1998-10-15 |
| NO890681L (no) | 1989-08-21 |
| NZ227977A (en) | 1990-10-26 |
| AU2990689A (en) | 1989-08-24 |
| IL89302A (en) | 1993-02-21 |
| CN1036761A (zh) | 1989-11-01 |
| DK74889A (da) | 1989-08-19 |
| JPH02149571A (ja) | 1990-06-08 |
| DE68911944T2 (de) | 1994-05-19 |
| HUT54148A (en) | 1991-01-28 |
| FI890694A0 (fi) | 1989-02-14 |
| KR960014794B1 (en) | 1996-10-19 |
| DK74889D0 (da) | 1989-02-17 |
| EP0329070B1 (en) | 1994-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE52387B1 (en) | Aroylimidazolones and analogues thereof | |
| CA1280754C (en) | Process for the preparation of heterocyclic substituted oxazolones | |
| CA1334201C (en) | Cardiotonic alkanoyl and aroyl oxazolones | |
| EP0190712A2 (en) | Pyrrole-3-carboxylate cardiotonic agents | |
| US4623651A (en) | Cardiotonic heterocyclocarbonyl- and acetyl-thiazolones | |
| US4743607A (en) | Cardiotonic tricyclic imidazolones | |
| US4728661A (en) | Cardiotonic phenyl oxazolones | |
| EP0078545B1 (en) | imidazolecarboxylic acid derivatives | |
| EP0293777B1 (en) | Cardiotonic tricyclic oxazolones | |
| US4762849A (en) | Cardiotonic alkanoylthiazolones | |
| HU205087B (en) | Process for producing 2,2'-bi(1h-imidazole) derivatives | |
| AU704798B2 (en) | 3-phenyl-1,4-dialkyl-1,2,4-triazolium salts and their use as antidepressants | |
| EP0118790A1 (en) | Novel aroylimidazolones | |
| JPH04334373A (ja) | 脊髄損傷による反射異常亢進の処置用３−アリール−５−アルキルチオ−４ｈ−１，２，４−トリアゾール類 | |
| US4803210A (en) | Cardiotonic tricyclic oxazolones |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed | ||
| MKLA | Lapsed |
Effective date: 20060131 |