CA1328875C - N-substituted amide derivatives - Google Patents

N-substituted amide derivatives

Info

Publication number
CA1328875C
CA1328875C CA000604689A CA604689A CA1328875C CA 1328875 C CA1328875 C CA 1328875C CA 000604689 A CA000604689 A CA 000604689A CA 604689 A CA604689 A CA 604689A CA 1328875 C CA1328875 C CA 1328875C
Authority
CA
Canada
Prior art keywords
formula
compound
methylenedioxyphenacyl
defined above
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000604689A
Other languages
English (en)
French (fr)
Inventor
Geng-Tao Liu
Liang Huang
Jin Zhou
Er-Chang Rao
Iwao Arai
Shohei Higuchi
Kensei Yoshikawa
Yan Li
Katsuo Hatayama
Tatsuhiko Sano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Materia Medica, CAMS&PUMC
Taisho Pharmaceutical Co Ltd
Original Assignee
Institute of Materia Medica, CAMS&PUMC
Taisho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute of Materia Medica, CAMS&PUMC, Taisho Pharmaceutical Co Ltd filed Critical Institute of Materia Medica, CAMS&PUMC
Application granted granted Critical
Publication of CA1328875C publication Critical patent/CA1328875C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
CA000604689A 1988-07-08 1989-07-04 N-substituted amide derivatives Expired - Fee Related CA1328875C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63-170727 1988-07-08
JP17072788 1988-07-08

Publications (1)

Publication Number Publication Date
CA1328875C true CA1328875C (en) 1994-04-26

Family

ID=15910274

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000604689A Expired - Fee Related CA1328875C (en) 1988-07-08 1989-07-04 N-substituted amide derivatives

Country Status (7)

Country Link
US (1) US4937360A (cg-RX-API-DMAC7.html)
EP (1) EP0350251B1 (cg-RX-API-DMAC7.html)
JP (1) JPH02124884A (cg-RX-API-DMAC7.html)
KR (1) KR970002232B1 (cg-RX-API-DMAC7.html)
AT (1) ATE102937T1 (cg-RX-API-DMAC7.html)
CA (1) CA1328875C (cg-RX-API-DMAC7.html)
DE (1) DE68913835T2 (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05310678A (ja) * 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
DE69331761T2 (de) * 1992-07-24 2002-09-12 The Regents Of The University Of California, Oakland Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
US5426225A (en) * 1993-12-30 1995-06-20 American Cyanamid Company Perfluoroalkanoyl aminonitriles
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
US5852008A (en) * 1995-01-24 1998-12-22 The Regents Of The University Of California Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors
KR100345203B1 (ko) * 2000-03-21 2002-07-24 현대자동차주식회사 리벳팅 장치
KR100345204B1 (ko) * 2000-03-21 2002-07-24 현대자동차주식회사 리벳 삽입 장치
KR20180057162A (ko) * 2016-11-22 2018-05-30 맥스엔지니어링(주) 면적차에 의해 연속 작동되는 피스톤과 절환 밸브가 내장된 선형 유체 펌프
US12492178B2 (en) 2021-09-01 2025-12-09 Empathbio, Inc. Stable polymorph of R-MDMA HCl
WO2023034510A1 (en) 2021-09-01 2023-03-09 ATAI Life Sciences AG Synthesis of mdma or its optically active ( r)- or ( s)-mdma isomers
US11845736B2 (en) 2021-10-01 2023-12-19 Empathbio, Inc. Prodrugs of MDMA, MDA, and derivatives thereof
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE332474C (de) * 1912-12-24 1921-02-01 Chem Fab Verfahren zur Darstellung von N-Alkyl-Acyl-Homopiperonylaminen
DE1543372A1 (de) * 1966-10-18 1971-04-01 Boehringer Sohn Ingelheim Verfahren zur Herstellung von o-substituierten 3,4-Dioxyphenylalkanolaminen
US4147799A (en) * 1971-06-24 1979-04-03 Kyowa Hakko Kogyo Co., Ltd. Process for reducing blood pressure and blocking β-adrenergic receptor
US4684651A (en) * 1981-03-17 1987-08-04 Mitsubishi Chemical Industries Limited Alkylenedioxybenzene and acid addition salts thereof useful as hypotensives
ES8203876A1 (es) * 1981-05-13 1982-04-01 Ferrer Int Procedimiento de obtencion de nuevos a-amino derivados ci- clicos del 1-(3',4'-metilendioxifenil)etanol
CH664565A5 (de) * 1985-05-09 1988-03-15 Ciba Geigy Ag Mittel zum schuetzen von kulturpflanzen vor der phytotoxischen wirkung von herbizid wirksamen chloracetaniliden.

Also Published As

Publication number Publication date
EP0350251B1 (en) 1994-03-16
US4937360A (en) 1990-06-26
ATE102937T1 (de) 1994-04-15
EP0350251A2 (en) 1990-01-10
KR970002232B1 (ko) 1997-02-26
DE68913835T2 (de) 1994-06-30
EP0350251A3 (en) 1990-03-14
DE68913835D1 (de) 1994-04-21
JPH0567634B2 (cg-RX-API-DMAC7.html) 1993-09-27
JPH02124884A (ja) 1990-05-14
KR900001673A (ko) 1990-02-27

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Legal Events

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MKLA Lapsed