CA1322749C - Prostaglandins of the d series, and tranquilizers and soporifics containing the same - Google Patents

Prostaglandins of the d series, and tranquilizers and soporifics containing the same

Info

Publication number
CA1322749C
CA1322749C CA000557480A CA557480A CA1322749C CA 1322749 C CA1322749 C CA 1322749C CA 000557480 A CA000557480 A CA 000557480A CA 557480 A CA557480 A CA 557480A CA 1322749 C CA1322749 C CA 1322749C
Authority
CA
Canada
Prior art keywords
dihydro
keto
pgd2
methyl
methyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000557480A
Other languages
English (en)
French (fr)
Inventor
Ryuzo Ueno
Ryuji Ueno
Ichie Kato
Tomio Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
Original Assignee
Ueno Seiyaku Oyo Kenkyujo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ueno Seiyaku Oyo Kenkyujo KK filed Critical Ueno Seiyaku Oyo Kenkyujo KK
Application granted granted Critical
Publication of CA1322749C publication Critical patent/CA1322749C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CA000557480A 1987-01-28 1988-01-27 Prostaglandins of the d series, and tranquilizers and soporifics containing the same Expired - Lifetime CA1322749C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1882187 1987-01-28
JP18821/1987 1987-01-28

Publications (1)

Publication Number Publication Date
CA1322749C true CA1322749C (en) 1993-10-05

Family

ID=11982228

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000557480A Expired - Lifetime CA1322749C (en) 1987-01-28 1988-01-27 Prostaglandins of the d series, and tranquilizers and soporifics containing the same

Country Status (8)

Country Link
US (3) US5073569A (enExample)
EP (1) EP0281239B1 (enExample)
KR (1) KR930006201B1 (enExample)
AT (1) ATE74126T1 (enExample)
CA (1) CA1322749C (enExample)
DE (1) DE3869444D1 (enExample)
ES (1) ES2032956T3 (enExample)
GR (1) GR3004281T3 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212200A (en) * 1987-09-18 1993-05-18 R-Tech Ueno, Ltd. Ocular hypotensive agents
ES2052735T3 (es) * 1987-09-18 1994-07-16 R Tech Ueno Ltd Un metodo para producir un agente hipotensor ocular.
US6420422B1 (en) 1987-09-18 2002-07-16 Sucampo Pharmaceuticals, Inc. Ocular hypotensive agents
JP2597629B2 (ja) 1988-02-26 1997-04-09 株式会社 上野製薬応用研究所 １３，１４−ジヒドロ−１５−ケトプロスタグランジン類の安定化
US6187813B1 (en) 1990-04-10 2001-02-13 Pharmacia & Upjohn Aktiebolag Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5296504A (en) * 1988-09-06 1994-03-22 Kabi Pharmacia Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
WO1990002553A1 (en) * 1988-09-06 1990-03-22 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
US5321128A (en) * 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
DE69019431T2 (de) * 1989-07-27 1995-09-14 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von 15-Keto-Prostansäure-Derivaten zur Herstellung eines Medikaments für die Verbesserung der Ausscheidung des Kaliumions.
US5234954A (en) * 1989-07-27 1993-08-10 K.K. Ueno Seiyaku Oyo Kenkyujo Treatment of hyperlipidemia with 15-keto-prostaglandin compounds
ATE121624T1 (de) * 1989-08-09 1995-05-15 Ueno Seiyaku Oyo Kenkyujo Kk Verwendung von prostansäurederivaten zur herstellung von arzneimitteln zur verbesserung der ausscheidung von nichtprotein in die därme.
CA2027814C (en) * 1989-10-20 1996-07-30 Ryuji Ueno Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
CA2030345C (en) * 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5254588A (en) * 1989-11-22 1993-10-19 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of pulmonary dysfunction with 15-ketoprostaglandin compounds
US5256696A (en) * 1989-11-22 1993-10-26 Kabushikikaisha Ueno Seiyaku Oyo Kenkyujo Treatment of cardiac dysfunction with 15-ketoprostaglandin compounds
TW224942B (enExample) * 1990-04-04 1994-06-11 Adka Ueno Kk
CA2046069C (en) * 1990-07-10 2002-04-09 Ryuji Ueno Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
EP0503887B1 (en) * 1991-03-14 1996-08-28 R-Tech Ueno Ltd. Promotion of wound-healing with 15-keto-prostaglandin compounds
CA2334355C (en) 1998-05-25 2009-01-27 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
EP1267882B1 (en) 2000-03-24 2009-04-15 Sucampo AG Prostaglandins for the treatment of eye disease caused by light irradiation like photoretinitis
NZ521784A (en) * 2000-04-06 2005-04-29 Sucampo Ag Bile secretion promoting composition
TWI302100B (en) 2001-05-02 2008-10-21 Sucampo Ag Composition for treating drug-induced constipation
EP1420794B1 (en) 2001-08-31 2017-12-27 Sucampo AG Prostaglandin analogs as chloride channel openers
DK1562604T3 (da) * 2002-10-23 2012-04-02 Sucampo Ag Prostaglandinforbindelser til behandling af fedme
BRPI0317740B8 (pt) 2002-12-27 2021-05-25 Sucampo Ag uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1
ATE489096T1 (de) * 2003-07-03 2010-12-15 Sucampo Ag Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI348386B (en) * 2003-08-12 2011-09-11 R Tech Ueno Ltd Composition and method for promoting hair growth
ES2431640T3 (es) 2003-08-21 2013-11-27 Sucampo Ag Composición oftálmica que comprende éster isopropílico de unoprostona y un agente de viscosidad
JP4690814B2 (ja) * 2004-08-02 2011-06-01 株式会社アールテック・ウエノ プロスタグランジン誘導体の製造法
DK1841433T3 (da) 2005-01-27 2012-01-16 Sucampo Ag Præparat til behandling af lidelser i centralnervesystemet
DE602006018583D1 (de) 2005-03-04 2011-01-13 Sucampo Ag Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten
US20060281818A1 (en) 2005-03-21 2006-12-14 Sucampo Ag, North Carolina State University Method for treating mucosal disorders
WO2006109881A1 (en) * 2005-04-12 2006-10-19 Sucampo Ag Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
CA2637274C (en) 2006-01-24 2013-06-04 R-Tech Ueno, Ltd. Soft-gelatin capsule formulation
EP1984027B1 (en) * 2006-01-24 2015-12-30 R-Tech Ueno, Ltd. Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
JPWO2007105691A1 (ja) 2006-03-13 2009-07-30 株式会社アールテック・ウエノ 水性組成物
US8871752B2 (en) * 2008-02-19 2014-10-28 Sucampo Ag Method for modulating stem cell growth
US8609729B2 (en) 2009-04-15 2013-12-17 Sucampo Ag Method for treating macular degeneration
US8569279B2 (en) * 2009-05-27 2013-10-29 Sucampo Ag Method for modulating claudin mediated functions
US9084815B2 (en) * 2009-09-16 2015-07-21 Sucampo Ag Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
CN103561748A (zh) 2011-04-07 2014-02-05 苏坎波公司 治疗眼疲劳的方法
RU2648474C2 (ru) * 2011-08-05 2018-03-26 Сукампо Аг Способ лечения шизофрении
AR092821A1 (es) 2012-04-20 2015-05-06 Sucampo Ag Conjugado de derivado de acido graso-polimero
US20150057351A1 (en) 2013-08-22 2015-02-26 Sucampo Ag Method for treating neuropathic pain
US20170020890A1 (en) 2015-06-19 2017-01-26 Sucampo Ag Pharmaceutical composition comprising fatty acid derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1476661A (en) * 1974-05-13 1977-06-16 American Cyanamid Co Prostaglandins
ES2052735T3 (es) * 1987-09-18 1994-07-16 R Tech Ueno Ltd Un metodo para producir un agente hipotensor ocular.

Also Published As

Publication number Publication date
US5073569A (en) 1991-12-17
DE3869444D1 (de) 1992-04-30
EP0281239A3 (en) 1988-09-21
GR3004281T3 (enExample) 1993-03-31
ATE74126T1 (de) 1992-04-15
KR880008986A (ko) 1988-09-13
ES2032956T3 (es) 1993-03-01
EP0281239B1 (en) 1992-03-25
US5137915A (en) 1992-08-11
EP0281239A2 (en) 1988-09-07
KR930006201B1 (ko) 1993-07-08
US5534547A (en) 1996-07-09

Similar Documents

Publication Publication Date Title
CA1322749C (en) Prostaglandins of the d series, and tranquilizers and soporifics containing the same
CA1324129C (en) Prostaglandins of the f series
KR100526282B1 (ko) 디플루오로프로스타글란딘유도체및그의용도
US5591887A (en) Prostaglandins of the F series
IE62483B1 (en) 9-Halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
EP0198829B1 (de) 9-halogen-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US3931296A (en) Trans-Δ2 -prostaglandins
JP2597649B2 (ja) 気管・気管支拡張剤
JPH0764808B2 (ja) 新規９―ハロゲンプロスタグランジン及びその製法
US4004020A (en) Novel prostanoic acid derivatives and process for the preparation thereof
US4235930A (en) Novel acetylenic prostaglandins and processes for the preparation thereof
IE46864B1 (en) Esters of prostan-1-ol derivatives,methods for their preparation and compositions containing them
US4088775A (en) 15-Ethylenedioxy-prostanoic acid derivatives and esters thereof and intermediates thereof
CA1092102A (en) 11-oxo-prostaglandin derivatives and processes for their manufacture
FR2554448A1 (fr) Derives furyles de prostaglandines 16-substituees et procede pour leur fabrication
Carpio et al. Synthesis and gastric antisecretory properties of allenic 16-phenoxy-omega-tetranor prostaglandin E analogs
US4315013A (en) Certain pyrrole analogs of prostacyclin derivatives
IE45773B1 (en) 11-deoxy-11-oxaprostaglandin compounds
JPS6210226B2 (enExample)
US3857831A (en) W-carbohydroxyalkyl esters of prostaglandins
JPS5852992B2 (ja) ２ａ，２ｂ−ジホモ−１５メチルＰＧＦｚｘ誘導体の製法
HU206342B (en) Process for producing 6-oxo-prostaglandine derivatives and pharmaceutical compositions containing them as active components
JPH07103096B2 (ja) プロスタグランジンｄ類およびそれを含む鎮静・睡眠剤
HU196746B (en) Process for producing in 6-position halogenated prostaglandins and pharmaceutical compositions comprising such active ingredient
GB2225573A (en) 13,14-dihydro-15-keto-PGFs

Legal Events

Date Code Title Description
MKEX Expiry

Effective date: 20101005