CA1314562C - Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles - Google Patents

Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles

Info

Publication number
CA1314562C
CA1314562C CA000589229A CA589229A CA1314562C CA 1314562 C CA1314562 C CA 1314562C CA 000589229 A CA000589229 A CA 000589229A CA 589229 A CA589229 A CA 589229A CA 1314562 C CA1314562 C CA 1314562C
Authority
CA
Canada
Prior art keywords
compound
5alkyl
alkyl
beta
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000589229A
Other languages
English (en)
French (fr)
Inventor
William T. Han
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of CA1314562C publication Critical patent/CA1314562C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/31Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing rings other than six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA000589229A 1988-01-26 1989-01-26 Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles Expired - Fee Related CA1314562C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/148,540 US4888357A (en) 1988-01-26 1988-01-26 Antiarthritic β-cycloalkyl-β-oxopropionitriles
US148,540 1988-01-26

Publications (1)

Publication Number Publication Date
CA1314562C true CA1314562C (en) 1993-03-16

Family

ID=22526203

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000589229A Expired - Fee Related CA1314562C (en) 1988-01-26 1989-01-26 Antiarthritic beta-cyclo-alkyl-beta-oxopropionitriles

Country Status (7)

Country Link
US (1) US4888357A (US06380249-20020430-C00031.png)
EP (1) EP0326107B1 (US06380249-20020430-C00031.png)
JP (1) JPH021451A (US06380249-20020430-C00031.png)
AT (1) ATE80157T1 (US06380249-20020430-C00031.png)
CA (1) CA1314562C (US06380249-20020430-C00031.png)
DE (1) DE68902647T2 (US06380249-20020430-C00031.png)
GR (1) GR3005584T3 (US06380249-20020430-C00031.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92508A0 (en) * 1988-12-08 1990-08-31 Ciba Geigy Ag Novel alpha-cyano-beta-oxopropionamides
IL99811A (en) * 1990-10-30 1996-03-31 Roussel Uclaf 3-Cycloalkyl-propanamides, tautomeric forms of these, their salts, method of preparation, use as drugs and preparations containing them
GB9023535D0 (en) * 1990-10-30 1990-12-12 Roussel Lab Ltd Chemical compounds
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf History of 3-cycloalkyl-prop-2-anamide
GB9300083D0 (en) 1993-01-05 1993-03-03 Roussel Lab Ltd Chemical compounds
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
JP2594965Y2 (ja) * 1993-12-27 1999-05-24 株式会社柿崎製作所 道路付帯設備用支柱のキャップ
GB9405229D0 (en) * 1994-03-17 1994-04-27 Rhone Poulenc Agriculture Compositions of matter
JP5544892B2 (ja) * 2010-01-19 2014-07-09 日亜化学工業株式会社 2−シアノ−1,3−ジケトネート塩の製造法及びイオン液体

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016295A (en) * 1958-06-23 1962-01-09 Du Pont Method for altering the growth characteristics of plants
DE1237105B (de) * 1965-06-26 1967-03-23 Riedel De Haeen Ag Verfahren zur Herstellung von Thiocarbonsaeureamiden
US3406183A (en) * 1966-11-01 1968-10-15 American Home Prod 3-n-arylamino-3-mercapto-2-cyanoacrylamides
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2555789A1 (de) * 1975-12-11 1977-07-07 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4170656A (en) * 1977-05-31 1979-10-09 American Cyanamid Company Compositions containing cis-2-benzoyl-3-hydroxy-crotononitrile used to treat inflammation and joint deterioration
US4189436A (en) * 1977-11-22 1980-02-19 American Cyanamid Company β-oxo-3-thiophene propionitrile and β-amino-2-(3)-thiophene acrylonitriles
US4173650A (en) * 1978-11-03 1979-11-06 American Cyanamid Company Cis-2-benzoyl-3-hydroxy-2-alkenonitriles as anti-inflammatory agents
US4197310A (en) * 1979-04-30 1980-04-08 American Cyanamid Company Thiophenepropionitriles
US4256759A (en) * 1979-06-11 1981-03-17 Ciba-Geigy Corporation Alphacarbamoyl-pyrrolpropionitriles
US4254047A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-thioalkenoic acid esters
US4254048A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl alkylidene acetoacetonitriles
US4254049A (en) * 1979-12-17 1981-03-03 American Cyanamid Company Substituted phenyl-2-cyano-2-alkenoic acid esters
US4435407A (en) * 1982-01-07 1984-03-06 Ciba-Geigy Corporation Certain substituted β-oxo-α-carbamoylpyrrolepropionitriles
DE3209472C2 (de) * 1982-03-16 1984-05-17 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von 3-Oxonitrilen sowie neue 3-Oxonitrile
DE3217446A1 (de) * 1982-05-08 1983-11-24 A. Nattermann & Cie GmbH, 5000 Köln Substituierte thiocarbamoyl-thenoylacetonitrile, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4644010A (en) * 1982-09-28 1987-02-17 Ciba-Geigy Corporation Certain β-oxo-α-carbamoylpyrrolepropionitriles
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives

Also Published As

Publication number Publication date
EP0326107A1 (en) 1989-08-02
JPH021451A (ja) 1990-01-05
GR3005584T3 (US06380249-20020430-C00031.png) 1993-06-07
JPH0567616B2 (US06380249-20020430-C00031.png) 1993-09-27
ATE80157T1 (de) 1992-09-15
EP0326107B1 (en) 1992-09-02
DE68902647D1 (en) 1992-10-08
US4888357A (en) 1989-12-19
DE68902647T2 (de) 1993-02-04

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