CA1291164C - Indane sulfonamide antiarrythmic agents - Google Patents

Indane sulfonamide antiarrythmic agents

Info

Publication number
CA1291164C
CA1291164C CA000567186A CA567186A CA1291164C CA 1291164 C CA1291164 C CA 1291164C CA 000567186 A CA000567186 A CA 000567186A CA 567186 A CA567186 A CA 567186A CA 1291164 C CA1291164 C CA 1291164C
Authority
CA
Canada
Prior art keywords
compound
formula
alkyl
pharmaceutically acceptable
indane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA000567186A
Other languages
English (en)
French (fr)
Inventor
John Edmund Arrowsmith
Peter Edward Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB878720910A priority Critical patent/GB8720910D0/en
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Priority to CA000567186A priority patent/CA1291164C/en
Priority to DD88316361A priority patent/DD281596A5/de
Priority to DE8888307956T priority patent/DE3869289D1/de
Priority to AT88307956T priority patent/ATE73773T1/de
Priority to ES198888307956T priority patent/ES2032972T3/es
Priority to EP88307956A priority patent/EP0307121B1/en
Priority to IE266588A priority patent/IE61505B1/en
Priority to FI884070A priority patent/FI89909C/fi
Priority to PT88406A priority patent/PT88406B/pt
Priority to DK488588A priority patent/DK488588A/da
Priority to CA000576405A priority patent/CA1320726C/en
Priority to JP63222190A priority patent/JP2653850B2/ja
Application granted granted Critical
Publication of CA1291164C publication Critical patent/CA1291164C/en
Priority to GR920400955T priority patent/GR3004627T3/el
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000567186A 1987-09-05 1988-05-19 Indane sulfonamide antiarrythmic agents Expired - Lifetime CA1291164C (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB878720910A GB8720910D0 (en) 1987-09-05 1987-09-05 Antiarrhythmic agents
CA000567186A CA1291164C (en) 1987-09-05 1988-05-19 Indane sulfonamide antiarrythmic agents
DD88316361A DD281596A5 (de) 1987-09-05 1988-06-02 Verfahren zur hersteung antiarrhytmischer mittel
EP88307956A EP0307121B1 (en) 1987-09-05 1988-08-26 Sulphonamide antiarrhythmic agents
AT88307956T ATE73773T1 (de) 1987-09-05 1988-08-26 Antiarrhythmische mittel auf basis von sulfonamiden.
ES198888307956T ES2032972T3 (es) 1987-09-05 1988-08-26 Agentes antiarritmicos a base de sulfonamidas.
DE8888307956T DE3869289D1 (de) 1987-09-05 1988-08-26 Antiarrhythmische mittel auf basis von sulfonamiden.
FI884070A FI89909C (fi) 1987-09-05 1988-09-02 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sulfonamidderivat och mellanprodukter
PT88406A PT88406B (pt) 1987-09-05 1988-09-02 Processo para a preparacao de agentes antiarritmicos de piperidino-ou morfolino-sulfonamidas
DK488588A DK488588A (da) 1987-09-05 1988-09-02 Sulfonamid-forbindelser, farmaceutiske praeparater indeholdende disse og anvendelse af forbindelserne til fremstilling af antiarytmiske laegemidler
CA000576405A CA1320726C (en) 1987-09-05 1988-09-02 Sulphonamide antiarrhythmic agents
IE266588A IE61505B1 (en) 1987-09-05 1988-09-02 Sulphonamide antiarrhythmic agents
JP63222190A JP2653850B2 (ja) 1987-09-05 1988-09-05 スルホンアミド抗不整脈剤
GR920400955T GR3004627T3 (https=) 1987-09-05 1992-05-18

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878720910A GB8720910D0 (en) 1987-09-05 1987-09-05 Antiarrhythmic agents
CA000567186A CA1291164C (en) 1987-09-05 1988-05-19 Indane sulfonamide antiarrythmic agents

Publications (1)

Publication Number Publication Date
CA1291164C true CA1291164C (en) 1991-10-22

Family

ID=25671902

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000567186A Expired - Lifetime CA1291164C (en) 1987-09-05 1988-05-19 Indane sulfonamide antiarrythmic agents
CA000576405A Expired - Fee Related CA1320726C (en) 1987-09-05 1988-09-02 Sulphonamide antiarrhythmic agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA000576405A Expired - Fee Related CA1320726C (en) 1987-09-05 1988-09-02 Sulphonamide antiarrhythmic agents

Country Status (13)

Country Link
EP (1) EP0307121B1 (https=)
JP (1) JP2653850B2 (https=)
AT (1) ATE73773T1 (https=)
CA (2) CA1291164C (https=)
DD (1) DD281596A5 (https=)
DE (1) DE3869289D1 (https=)
DK (1) DK488588A (https=)
ES (1) ES2032972T3 (https=)
FI (1) FI89909C (https=)
GB (1) GB8720910D0 (https=)
GR (1) GR3004627T3 (https=)
IE (1) IE61505B1 (https=)
PT (1) PT88406B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4906634A (en) * 1988-03-08 1990-03-06 Schering A.G. Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
DE69231854T2 (de) * 1991-04-17 2001-10-04 Pharmacia & Upjohn Co., Kalamazoo Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
DE4335718A1 (de) * 1993-10-20 1995-04-27 Merck Patent Gmbh Cyclische Aminderivate
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
AU2002360561A1 (en) 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
GB2543296A (en) 2015-10-13 2017-04-19 Indivior Uk Ltd Dopamine D3 receptor antagonists having a morpholine moiety
TW202334100A (zh) * 2021-11-08 2023-09-01 瑞士商赫孚孟拉羅股份公司 芳香族硝基化合物之催化氫化

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068669A1 (en) * 1981-06-20 1983-01-05 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
DE3476386D1 (de) * 1983-11-02 1989-03-02 Beecham Group Plc Morpholine derivatives
EP0164865B1 (en) * 1984-05-04 1988-12-21 The Upjohn Company N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use

Also Published As

Publication number Publication date
JPS6471856A (en) 1989-03-16
GB8720910D0 (en) 1987-10-14
IE882665L (en) 1989-03-05
FI89909C (fi) 1993-12-10
DE3869289D1 (de) 1992-04-23
GR3004627T3 (https=) 1993-04-28
CA1320726C (en) 1993-07-27
EP0307121B1 (en) 1992-03-18
DK488588D0 (da) 1988-09-02
PT88406A (pt) 1989-07-31
IE61505B1 (en) 1994-11-02
DD281596A5 (de) 1990-08-15
ES2032972T3 (es) 1993-03-01
EP0307121A1 (en) 1989-03-15
DK488588A (da) 1989-03-06
FI89909B (fi) 1993-08-31
JP2653850B2 (ja) 1997-09-17
FI884070L (fi) 1989-03-06
PT88406B (pt) 1992-10-30
ATE73773T1 (de) 1992-04-15
FI884070A0 (fi) 1988-09-02

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Legal Events

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