CA1263959C - - Google Patents

Info

Publication number
CA1263959C
CA1263959C CA 458335 CA458335A CA1263959C CA 1263959 C CA1263959 C CA 1263959C CA 458335 CA458335 CA 458335 CA 458335 A CA458335 A CA 458335A CA 1263959 C CA1263959 C CA 1263959C
Authority
CA
Canada
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA 458335
Other versions
CA1256108A (fr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000575394A priority Critical patent/CA1263959A/fr
Publication of CA1256108A publication Critical patent/CA1256108A/fr
Application granted granted Critical
Publication of CA1263959C publication Critical patent/CA1263959C/xx
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA000458335A 1983-07-11 1984-07-09 Preparation de l-pyridyl-alcoyl-4-aryl-piperazines utiles comme antihypertenseurs; leur separation en antipodes optiques, et stereoisomeres ainsi obtenus Expired CA1256108A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000575394A CA1263959A (fr) 1983-07-11 1988-08-22 Methode de preparation de 1-pyridylalcoyl-4- arylpiperazines, utiles comme antihypertenseurs; leur separation en leurs antipodes optiques respectifs; stereoisomeres ainsi obtenues

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT48664/83A IT1200928B (it) 1983-07-11 1983-07-11 Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000575394A Division CA1263959A (fr) 1983-07-11 1988-08-22 Methode de preparation de 1-pyridylalcoyl-4- arylpiperazines, utiles comme antihypertenseurs; leur separation en leurs antipodes optiques respectifs; stereoisomeres ainsi obtenues

Publications (2)

Publication Number Publication Date
CA1256108A CA1256108A (fr) 1989-06-20
CA1263959C true CA1263959C (fr) 1989-12-19

Family

ID=11267912

Family Applications (2)

Application Number Title Priority Date Filing Date
CA000458335A Expired CA1256108A (fr) 1983-07-11 1984-07-09 Preparation de l-pyridyl-alcoyl-4-aryl-piperazines utiles comme antihypertenseurs; leur separation en antipodes optiques, et stereoisomeres ainsi obtenus
CA000575394A Expired CA1263959A (fr) 1983-07-11 1988-08-22 Methode de preparation de 1-pyridylalcoyl-4- arylpiperazines, utiles comme antihypertenseurs; leur separation en leurs antipodes optiques respectifs; stereoisomeres ainsi obtenues

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA000575394A Expired CA1263959A (fr) 1983-07-11 1988-08-22 Methode de preparation de 1-pyridylalcoyl-4- arylpiperazines, utiles comme antihypertenseurs; leur separation en leurs antipodes optiques respectifs; stereoisomeres ainsi obtenues

Country Status (10)

Country Link
US (2) US4578467A (fr)
JP (1) JPS6089470A (fr)
BE (1) BE900136A (fr)
CA (2) CA1256108A (fr)
DE (2) DE3448320C2 (fr)
ES (2) ES8603461A1 (fr)
FR (1) FR2549059B1 (fr)
GB (2) GB2143235B (fr)
IT (1) IT1200928B (fr)
NL (1) NL8402198A (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2543139B1 (fr) * 1983-03-22 1985-08-16 Cerm Cent Europ Rech Mauvernay Derives de (1-alcoxy 2-amino) ethyl pyridine ou pyrazine, leur preparation et leur application en therapeutique
IT1200928B (it) * 1983-07-11 1989-01-27 Malesci Sas Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
US4975440A (en) * 1984-09-28 1990-12-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Optically-active 1,4-dihydropyridine
GB8530602D0 (en) * 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
FR2635105B1 (fr) * 1988-08-03 1991-01-25 Synthelabo Derives de piperazine et leur procede de preparation
US5382583A (en) * 1989-04-22 1995-01-17 John Wyeth & Brother, Limited Piperazine derivatives
US5364849A (en) * 1989-04-22 1994-11-15 John Wyeth & Brother, Limited 1-[3 or 4-[1-[4-piperazinyl]]-2 arylpropionyl or butryl]-heterocyclic derivatives
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
JPH11106375A (ja) * 1997-08-18 1999-04-20 Pfizer Pharmaceut Inc ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332949A (en) * 1962-11-13 1967-07-25 Sterling Drug Inc 1-phenyl-4-[2-(2-pyridyl)-ethyl] piperazines
NL143925C (fr) * 1965-03-09
CH624402A5 (en) 1974-03-01 1981-07-31 Malesci Sas Process for the preparation of novel heterocyclic derivatives of 1-alkyl-substituted 4-phenylpiperazine and use of the novel derivatives
IT1056055B (it) * 1974-03-01 1982-01-30 Malesci Sas Inst Farmaco Bilog Derivati eterocicli della 4 fenil riperazina i alchil sostituita ad azione farmacologica e relativo procedimento di preparazione
US3886167A (en) * 1974-03-06 1975-05-27 Us Army 2-Aryl-6-trifluoromethyl-4-pyridylcarbinolamine antimalarials
US4031108A (en) * 1974-10-09 1977-06-21 Pfizer Inc. 2-Hydroxymethyl-3-benzyloxypyridine-6-epoxyethane
GB1551993A (en) * 1976-09-21 1979-09-05 Malesci Sas Pharmacologiclly active derivatives of 1 alkyl 4-phenylpiperazines and the preparation thereof
DE2824764A1 (de) * 1978-06-06 1979-12-20 Hoechst Ag Neue pyridylpiperazinderivate und verfahren zu ihrer herstellung
IT1200928B (it) * 1983-07-11 1989-01-27 Malesci Sas Procedimento per la preparazione di 1-piridil-alchil-4-aril piperazine utili per la loro attivita' antiipertensiva,lloro separazione nei relativi antipodi ottici e composti stereoisomeri cosi' ottenuti

Also Published As

Publication number Publication date
JPS6089470A (ja) 1985-05-20
GB2143235A (en) 1985-02-06
GB2178039A (en) 1987-02-04
GB8417587D0 (en) 1984-08-15
US4692525A (en) 1987-09-08
DE3425477A1 (de) 1985-01-31
FR2549059A1 (fr) 1985-01-18
GB2143235B (en) 1987-08-19
DE3448320C2 (fr) 1991-04-11
DE3425477C2 (fr) 1990-03-15
BE900136A (fr) 1984-11-05
CA1256108A (fr) 1989-06-20
US4578467A (en) 1986-03-25
ES8606228A1 (es) 1986-04-01
CA1263959A (fr) 1989-12-19
GB2178039B (en) 1987-08-19
FR2549059B1 (fr) 1987-04-17
GB8621586D0 (en) 1986-10-15
ES545191A0 (es) 1986-04-01
IT8348664A0 (it) 1983-07-11
ES534170A0 (es) 1985-12-16
NL8402198A (nl) 1985-02-01
ES8603461A1 (es) 1985-12-16
IT1200928B (it) 1989-01-27

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Legal Events

Date Code Title Description
MKEX Expiry