CA1255271A - Apparatus and method for sealing capsules - Google Patents

Apparatus and method for sealing capsules

Info

Publication number
CA1255271A
CA1255271A CA000438716A CA438716A CA1255271A CA 1255271 A CA1255271 A CA 1255271A CA 000438716 A CA000438716 A CA 000438716A CA 438716 A CA438716 A CA 438716A CA 1255271 A CA1255271 A CA 1255271A
Authority
CA
Canada
Prior art keywords
gelatin
capsule
sealing
sealing fluid
capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000438716A
Other languages
English (en)
French (fr)
Inventor
Ivan Tomka
Fritz Wittwer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to CA000501422A priority Critical patent/CA1219214A/en
Application granted granted Critical
Publication of CA1255271A publication Critical patent/CA1255271A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/072—Sealing capsules, e.g. rendering them tamper-proof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/01—General aspects dealing with the joint area or with the area to be joined
    • B29C66/05—Particular design of joint configurations
    • B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
    • B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
    • B29C66/112—Single lapped joints
    • B29C66/1122—Single lap to lap joints, i.e. overlap joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/54—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles
    • B29C66/542—Joining several hollow-preforms, e.g. half-shells, to form hollow articles, e.g. for making balls, containers; Joining several hollow-preforms, e.g. half-cylinders, to form tubular articles joining hollow covers or hollow bottoms to open ends of container bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61G—TRANSPORT, PERSONAL CONVEYANCES OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
    • A61G2203/00—General characteristics of devices
    • A61G2203/30—General characteristics of devices characterised by sensor means
    • A61G2203/46—General characteristics of devices characterised by sensor means for temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
    • B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
    • B29C65/54—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts
    • B29C65/548—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive between pre-assembled parts by capillarity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7174—Capsules
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00—Receptacles
    • Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/17—Surface bonding means and/or assemblymeans with work feeding or handling means
    • Y10T156/1798—Surface bonding means and/or assemblymeans with work feeding or handling means with liquid adhesive or adhesive activator applying means

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Closing Of Containers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Formation And Processing Of Food Products (AREA)
CA000438716A 1983-02-18 1983-10-11 Apparatus and method for sealing capsules Expired CA1255271A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000501422A CA1219214A (en) 1983-02-18 1986-02-07 Sealed capsule

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/468,022 US4539060A (en) 1983-02-18 1983-02-18 Apparatus and method of sealing capsules
US468,022 1990-01-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000501422A Division CA1219214A (en) 1983-02-18 1986-02-07 Sealed capsule

Publications (1)

Publication Number Publication Date
CA1255271A true CA1255271A (en) 1989-06-06

Family

ID=23858126

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000438716A Expired CA1255271A (en) 1983-02-18 1983-10-11 Apparatus and method for sealing capsules

Country Status (15)

Country Link
US (1) US4539060A (cg-RX-API-DMAC10.html)
EP (1) EP0116743B1 (cg-RX-API-DMAC10.html)
JP (1) JPS59156349A (cg-RX-API-DMAC10.html)
KR (1) KR890000206B1 (cg-RX-API-DMAC10.html)
AT (1) ATE33346T1 (cg-RX-API-DMAC10.html)
AU (1) AU559678B2 (cg-RX-API-DMAC10.html)
BR (1) BR8306208A (cg-RX-API-DMAC10.html)
CA (1) CA1255271A (cg-RX-API-DMAC10.html)
DE (1) DE3376197D1 (cg-RX-API-DMAC10.html)
ES (1) ES8501976A1 (cg-RX-API-DMAC10.html)
IE (1) IE56363B1 (cg-RX-API-DMAC10.html)
IN (1) IN160442B (cg-RX-API-DMAC10.html)
PH (1) PH20191A (cg-RX-API-DMAC10.html)
SU (1) SU1393309A3 (cg-RX-API-DMAC10.html)
YU (1) YU44447B (cg-RX-API-DMAC10.html)

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JPS59105455A (ja) * 1982-11-23 1984-06-18 ワ−ナ−・ランバ−ト・カンパニ− カプセルを封止するための装置及び方法
US4656066A (en) * 1982-12-20 1987-04-07 Warner-Lambert Company Apparatus and method for sealing capsules
US4820364A (en) * 1983-05-23 1989-04-11 Capsulbond Incorporated Method for sealing capsules
DE3469408D1 (en) * 1983-06-13 1988-03-31 Capsulbond Inc Apparatus for sealing capsules
CN1003578B (zh) * 1984-10-25 1989-03-15 沃纳·兰伯特公司 改进的胶囊形状
GB2172570B (en) * 1985-03-21 1989-06-21 Warner Lambert Co Hard gelatin capsules.
IE58468B1 (en) * 1984-10-25 1993-09-22 Warner Lambert Co Method for sealing capsules and capsule
CH674800A5 (cg-RX-API-DMAC10.html) * 1986-03-12 1990-07-31 Warner Lambert Co
CA1308357C (en) * 1987-01-28 1992-10-06 Tohru Chiba Method for the preparation of a coated solid medicament
US4734149A (en) * 1987-03-20 1988-03-29 Warner-Lambert Company Apparatus for heatsealing gelatin capsules containing a medicament
US4724019A (en) * 1987-03-20 1988-02-09 Warner-Lambert Company Method and apparatus for sealing capsules
US4940499A (en) * 1989-05-23 1990-07-10 Warner-Lambert Company Method and apparatus for sealing capsules containing medicaments
US5188688A (en) * 1990-07-20 1993-02-23 Minnesota Mining And Manufacturing Company Method of sealing a gelatin capsule
GB9416902D0 (en) * 1994-08-20 1994-10-12 Scherer Corp R P Hydrophilic controlled release device
EP1072245A1 (en) 1999-07-30 2001-01-31 Warner-Lambert Company Method and apparatus for sealing capsules and capsules suitable for use in said method and apparatus
US6887916B2 (en) * 2000-12-28 2005-05-03 Kimberly-Clark Worldwide, Inc. Materials having controlled shrinkage and patterns and methods of making same
EP1262174A1 (en) 2001-06-01 2002-12-04 Celanese Ventures GmbH Two part hard shell capsule made of poly(1,4-alpha-D-glucane) and starch
MXPA04001395A (es) 2001-08-16 2004-05-27 Warner Lambert Co Mejoras en y con relacion a envases.
WO2004028460A2 (en) * 2002-09-26 2004-04-08 Probiohealth, Llc Prebiotic and preservative uses of oil-emulsified probiotic encapsulations
US8895060B2 (en) 2002-09-26 2014-11-25 Vita-Herb Nutriceuticals, Inc. Methods and apparatus for sealing capsules
EP1459725B1 (en) 2003-03-21 2007-10-17 Warner-Lambert Company LLC Apparatus for and method of sealing capsules
GB2401345A (en) * 2003-05-03 2004-11-10 Reckitt Benckiser Atomised aqueous composition sealing of water soluble members
US8377471B2 (en) * 2005-08-09 2013-02-19 Capsugel Belgium Nv Container
US20070036830A1 (en) * 2005-08-09 2007-02-15 Stef Vanquickenborne Container
US20070053972A1 (en) * 2005-09-08 2007-03-08 Cadbury Adams Usa Llc. Gelatin capsules containing actives
EP1886657A1 (en) * 2006-08-11 2008-02-13 Pfizer Products Inc. Method and apparatus for sealing capsules
US20080038334A1 (en) * 2006-08-08 2008-02-14 John Zazula Method for producing and a system for cooling a hot-filled softgel capsule
CA2666926C (en) * 2006-10-24 2014-06-17 Pfizer Products Inc. Transfer line
CA2667167C (en) 2006-10-27 2014-02-18 Pfizer Products Inc. Hydroxypropyl methyl cellulose hard capsules and process of manufacture
EP2111837B1 (en) * 2007-02-15 2016-10-12 Qualicaps Co., Ltd. Band seal for hard capsules having peg encapsulated therein
PT103765A (pt) * 2007-06-20 2008-12-22 Inst Superior Tecnico Síntese e aplicação de uma família de novos materiais resultantes do cruzamento entre gelatina e sais orgânicos
US8810259B2 (en) 2009-11-13 2014-08-19 Capsugel Belgium Nv Method of inspection of sealed capsules with a process of determination of the quality of the seal and related equipment for in-line inspection
WO2012028702A1 (de) 2010-09-02 2012-03-08 Innogel Ag Hartkapsel auf stärkebasis sowie tauchbeschichtungszusammensetzung, tauchbad und verfahren zur herstellung derselben
CN101953816B (zh) * 2010-09-08 2015-01-07 浙江昂利康胶囊有限公司 药用空心胶囊、制备方法及其制造设备
EP2720686A4 (en) * 2011-06-15 2014-12-17 Orient Pharma Co Ltd MULTILAYER CAPSULE AND MANUFACTURING METHOD THEREFOR
CA2850447C (en) * 2011-10-06 2019-05-28 Bio Capsule Pharmaceutical And Nutritional Products Proprietary Limited A method and apparatus for manufacturing a capsule
JP6397813B2 (ja) 2012-05-02 2018-09-26 キャプシュゲル・ベルジウム・エヌ・ヴィ ヒドロキシプロピルメチルセルロースアセテートスクシネート(hpmcas)の水性分散液
EP3004224B1 (en) 2013-06-04 2022-01-26 Monosol, LLC Water-soluble film sealing solutions, related methods, and related articles
EP3065720A1 (en) 2013-11-04 2016-09-14 Capsugel Belgium NV Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
KR101706725B1 (ko) * 2015-06-12 2017-02-16 주식회사 세종파마텍 정제 코팅 스프레이건 어셈블리
CN106619128B (zh) * 2015-11-04 2019-12-06 曹荣华 胶囊的封存组合物及其封存方法
EP3167868A1 (en) * 2015-11-16 2017-05-17 Capsugel Belgium NV Tamperproof dosage form
EP3167870B1 (en) * 2015-11-16 2024-01-03 Capsugel Belgium NV Tamperproof oral dosage form
EP3167869B1 (en) * 2015-11-16 2025-02-12 Capsugel Belgium NV Tamperproof oral dosage form
EP3167867A1 (en) * 2015-11-16 2017-05-17 Capsugel Belgium NV Tamperproof dosage form
EP3199148B1 (en) 2016-01-28 2020-12-02 Capsugel Belgium NV Compositions and resulting hard capsules comprising hydrophilic coloring foodstuff concentrates
EP3219300B1 (en) 2016-03-15 2019-06-19 Capsugel Belgium NV Aseptic hard capsule sealing apparatus and methods
EP3272340A1 (en) 2016-07-22 2018-01-24 Capsugel Belgium NV Acid resistant capsules
IL266695B (en) * 2016-12-08 2022-09-01 Scherer Technologies Llc R P A method of damping stress in capsule shells to reduce the tendency to break
HRP20250979T1 (hr) 2017-04-14 2025-10-24 Capsugel Belgium Nv Pululan kapsule
CN107157949B (zh) * 2017-06-09 2021-01-15 厦门普罗康客科技有限公司 硬胶囊内部封口的方法及其应用
EP3607931B1 (de) * 2018-08-07 2023-03-29 Harro Höfliger Verpackungsmaschinen GmbH Kapselverschliesseinrichtung zum verschliessen zweiteiliger kapseln
US12138227B2 (en) * 2019-05-15 2024-11-12 ACG PAM Pharma Technologies Pvt. Ltd. Capsule sealing system and method therefor
WO2022069660A1 (en) 2020-10-02 2022-04-07 Capsugel Belgium Nv Device for dispensing single droplets into a cap or body of a capsule
WO2026072936A1 (en) * 2024-09-30 2026-04-02 Capsugel Belgium Nv Low acid sealing fluid for sealing capsules

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JPS5459312A (en) * 1977-10-13 1979-05-12 Chukyo Electric Co Closing of hard capsule
US4281763A (en) * 1979-10-31 1981-08-04 Pace Joseph A Two-piece hardshell, soluble and digestible liquid containing gelatin capsule

Also Published As

Publication number Publication date
IE56363B1 (en) 1991-07-03
KR890000206B1 (ko) 1989-03-10
JPS59156349A (ja) 1984-09-05
SU1393309A3 (ru) 1988-04-30
ATE33346T1 (de) 1988-04-15
YU219583A (en) 1986-02-28
BR8306208A (pt) 1984-11-13
JPH0140627B2 (cg-RX-API-DMAC10.html) 1989-08-30
AU559678B2 (en) 1987-03-19
EP0116743B1 (en) 1988-04-06
YU44447B (en) 1990-08-31
US4539060A (en) 1985-09-03
PH20191A (en) 1986-10-16
IE832820L (en) 1984-08-18
ES526230A0 (es) 1984-12-16
IN160442B (cg-RX-API-DMAC10.html) 1987-07-11
AU1977383A (en) 1984-08-23
EP0116743A1 (en) 1984-08-29
ES8501976A1 (es) 1984-12-16
KR840007664A (ko) 1984-12-20
DE3376197D1 (en) 1988-05-11

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