CA1247602A - Rcrf and analogs - Google Patents
Rcrf and analogsInfo
- Publication number
- CA1247602A CA1247602A CA000451673A CA451673A CA1247602A CA 1247602 A CA1247602 A CA 1247602A CA 000451673 A CA000451673 A CA 000451673A CA 451673 A CA451673 A CA 451673A CA 1247602 A CA1247602 A CA 1247602A
- Authority
- CA
- Canada
- Prior art keywords
- leu
- glu
- ala
- gln
- ile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229940095064 tartrate Drugs 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- LJGOZJHDEQHJRI-SITYYSIOSA-N α-helical crf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(C)C)C1=CNC=N1 LJGOZJHDEQHJRI-SITYYSIOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2228—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Control Of Eletrric Generators (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Vehicle Body Suspensions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Control Of El Displays (AREA)
- Bipolar Transistors (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US484,931 | 1983-04-14 | ||
| US06/484,931 US4489163A (en) | 1983-04-14 | 1983-04-14 | rCRF and analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1247602A true CA1247602A (en) | 1988-12-28 |
Family
ID=23926236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000451673A Expired CA1247602A (en) | 1983-04-14 | 1984-04-10 | Rcrf and analogs |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4489163A (enExample) |
| EP (1) | EP0122798B1 (enExample) |
| JP (1) | JPH0689034B2 (enExample) |
| KR (1) | KR900006559B1 (enExample) |
| AT (1) | ATE96807T1 (enExample) |
| AU (1) | AU565699B2 (enExample) |
| CA (1) | CA1247602A (enExample) |
| DE (1) | DE3486238T2 (enExample) |
| DK (1) | DK172682B1 (enExample) |
| ES (1) | ES8606406A1 (enExample) |
| GR (1) | GR81467B (enExample) |
| IE (1) | IE61617B1 (enExample) |
| IL (1) | IL71326A (enExample) |
| NZ (1) | NZ207779A (enExample) |
| PH (1) | PH23123A (enExample) |
| ZA (1) | ZA842460B (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3587276T2 (de) * | 1984-02-23 | 1993-07-29 | Salk Inst For Biological Studi | Crf-analoga. |
| FR2567524B1 (fr) * | 1984-07-10 | 1987-11-27 | Sanofi Sa | Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires |
| US4801612A (en) * | 1986-07-03 | 1989-01-31 | Regents Of The University Of California | Method of inhibiting inflammatory response |
| DE3703340A1 (de) * | 1987-02-04 | 1988-08-18 | Dirck Dr Med Oppermann | Pharmazeutische zubereitung zur behandlung der herzinsuffizienz |
| IE64788B1 (en) | 1988-06-21 | 1995-09-06 | Salk Inst For Biological Studi | CRF analogs |
| CA1341051C (en) * | 1988-09-23 | 2000-07-11 | Jean Edouard Frederic Rivier | Crf antagonists |
| CA1340964C (en) * | 1988-09-30 | 2000-04-18 | Jean E. F. Rivier | Crf analogs |
| US5278146A (en) * | 1988-09-30 | 1994-01-11 | The Salk Institute For Biological Studies | CRF analogs |
| CA2002004A1 (en) * | 1988-11-14 | 1990-05-14 | Karl P. Lederis | Fish crf |
| US5488033A (en) * | 1989-07-28 | 1996-01-30 | The Regents Of The University Of California | Treatment to reduce edema |
| US5137871A (en) * | 1989-07-28 | 1992-08-11 | Regents Of The University Of California | Treatment to reduce edema for brain and musculature injuries |
| DE3942925A1 (de) * | 1989-12-23 | 1991-06-27 | Swf Auto Electric Gmbh | Elektrischer schalter, insbesondere blinkerschalter fuer kraftfahrzeuge |
| US5177060A (en) * | 1990-01-09 | 1993-01-05 | Regents Of The University Of California | Anti-inflammatory peptides and treatment to inhibit vascular leakage in injured tissues |
| US5480869A (en) * | 1990-01-09 | 1996-01-02 | The Regents Of The University Of California | Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues |
| US5245009A (en) * | 1990-03-23 | 1993-09-14 | The Salk Institute For Biological Studies | CRF antagonists |
| US5235036A (en) * | 1991-05-31 | 1993-08-10 | The Salk Institute For Biological Studies | Crf analogs |
| US5374621A (en) * | 1991-09-13 | 1994-12-20 | Regents Of The University Of California | Neurotensin method for inhibiting vascular leakage |
| US5728545A (en) * | 1993-06-18 | 1998-03-17 | The Salk Institute Of Biological Studies | Cloning and recombinant production of CRF receptor (S) |
| US6495343B1 (en) | 1993-06-18 | 2002-12-17 | The Salk Institute For Biological Studies | Cloning and recombinant production of CRF receptor(s) |
| US6638905B2 (en) | 1993-06-18 | 2003-10-28 | The Salk Institute For Biological Studies | Cloning and recombinant production of CFR receptor(s) |
| US6039956A (en) * | 1994-09-12 | 2000-03-21 | Pennsylvania, Trustees Of The University Of, The | Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder |
| US5830866A (en) * | 1994-09-12 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Corticotropin release inhibiting factor and methods of using same |
| US6670140B2 (en) * | 2001-03-06 | 2003-12-30 | The Procter & Gamble Company | Methods for identifying compounds for regulating muscle mass or function using corticotropin releasing factor receptors |
| US7141546B1 (en) | 2001-08-01 | 2006-11-28 | The Salk Institute For Biologicial Studies | CRFR2 selective ligands |
| WO2003011823A2 (en) * | 2001-08-01 | 2003-02-13 | The Salk Institute For Biological Studies | Crfr1 selective ligands |
| US20090035298A1 (en) * | 2007-04-23 | 2009-02-05 | Washington University In St. Louis | Methods to treat alzheimer's disease or other amyloid beta accumulation associated disorders |
| AU2009241813A1 (en) * | 2008-04-30 | 2009-11-05 | Neutron Row | Methods of using corticotropin-releasing factor for the treatment of cancer |
| RU2012102259A (ru) | 2009-06-24 | 2013-07-27 | Стефен ЭВАНС-ФРИК | Способы применения кортикотропин-рилизинг фактора для лечения рака |
| JP6100699B2 (ja) | 2010-12-22 | 2017-03-22 | ザ ソルク インスティテュート フォー バイオロジカル スタディーズ | 環状ｃｒｆアンタゴニストペプチド及びその薬学的に許容される塩 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR67608E (fr) * | 1955-02-22 | 1958-03-14 | Variateur de vitesse, notamment pour cycles | |
| GB2016015B (en) | 1978-01-22 | 1982-05-06 | Hayashibara Co | Method of preparing interferon and preparations containing interferon |
| US4244946A (en) | 1979-06-11 | 1981-01-13 | The Salk Institute For Biological Studies | Water-soluble peptides affecting gonadal function |
| US4415558A (en) | 1981-06-08 | 1983-11-15 | The Salk Institute For Biological Studies | CRF And analogs |
| WO1983001783A1 (en) | 1981-11-23 | 1983-05-26 | University Patents Inc | Control of dna sequence transcription |
| GB2118190B (en) * | 1982-04-13 | 1985-05-01 | Erba Farmitalia | Peptides with sauvagine-like activity |
-
1983
- 1983-04-14 US US06/484,931 patent/US4489163A/en not_active Expired - Lifetime
-
1984
- 1984-03-23 IL IL71326A patent/IL71326A/xx not_active IP Right Cessation
- 1984-03-27 DK DK198401697A patent/DK172682B1/da not_active IP Right Cessation
- 1984-03-28 GR GR74243A patent/GR81467B/el unknown
- 1984-04-02 ZA ZA842460A patent/ZA842460B/xx unknown
- 1984-04-09 IE IE86784A patent/IE61617B1/en not_active IP Right Cessation
- 1984-04-09 NZ NZ207779A patent/NZ207779A/en unknown
- 1984-04-10 CA CA000451673A patent/CA1247602A/en not_active Expired
- 1984-04-11 PH PH30530A patent/PH23123A/en unknown
- 1984-04-11 JP JP59072606A patent/JPH0689034B2/ja not_active Expired - Lifetime
- 1984-04-12 AU AU26777/84A patent/AU565699B2/en not_active Expired
- 1984-04-13 KR KR1019840001956A patent/KR900006559B1/ko not_active Expired
- 1984-04-13 AT AT84302558T patent/ATE96807T1/de not_active IP Right Cessation
- 1984-04-13 EP EP84302558A patent/EP0122798B1/en not_active Expired - Lifetime
- 1984-04-13 DE DE84302558T patent/DE3486238T2/de not_active Expired - Lifetime
- 1984-04-13 ES ES531585A patent/ES8606406A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0689034B2 (ja) | 1994-11-09 |
| KR840009075A (ko) | 1984-12-24 |
| EP0122798A3 (en) | 1986-09-03 |
| EP0122798B1 (en) | 1993-11-03 |
| IL71326A (en) | 1987-11-30 |
| DE3486238D1 (de) | 1993-12-09 |
| KR900006559B1 (ko) | 1990-09-13 |
| IE840867L (en) | 1984-10-14 |
| EP0122798A2 (en) | 1984-10-24 |
| PH23123A (en) | 1989-05-05 |
| GR81467B (enExample) | 1984-12-11 |
| ES531585A0 (es) | 1986-04-01 |
| NZ207779A (en) | 1988-04-29 |
| US4489163A (en) | 1984-12-18 |
| ZA842460B (en) | 1984-11-28 |
| AU565699B2 (en) | 1987-09-24 |
| ATE96807T1 (de) | 1993-11-15 |
| ES8606406A1 (es) | 1986-04-01 |
| IL71326A0 (en) | 1984-06-29 |
| DK172682B1 (da) | 1999-05-25 |
| IE61617B1 (en) | 1994-11-16 |
| DE3486238T2 (de) | 1994-03-03 |
| AU2677784A (en) | 1984-10-18 |
| DK169784A (da) | 1984-10-15 |
| DK169784D0 (da) | 1984-03-27 |
| JPS59199662A (ja) | 1984-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |