CA1247101A - 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds, intermediates and methods for their preparation, and pharmaceutical compositions containing them - Google Patents
5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds, intermediates and methods for their preparation, and pharmaceutical compositions containing themInfo
- Publication number
- CA1247101A CA1247101A CA000496048A CA496048A CA1247101A CA 1247101 A CA1247101 A CA 1247101A CA 000496048 A CA000496048 A CA 000496048A CA 496048 A CA496048 A CA 496048A CA 1247101 A CA1247101 A CA 1247101A
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- formula
- alkyl
- pyrazolin
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
- C07D231/22—One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3442860.7 | 1984-11-24 | ||
| DE19843442860 DE3442860A1 (de) | 1984-11-24 | 1984-11-24 | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3- on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1247101A true CA1247101A (en) | 1988-12-20 |
Family
ID=6251032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000496048A Expired CA1247101A (en) | 1984-11-24 | 1985-11-22 | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compounds, intermediates and methods for their preparation, and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4672063A (enExample) |
| EP (1) | EP0185909B1 (enExample) |
| JP (1) | JPS61148164A (enExample) |
| AT (1) | ATE50448T1 (enExample) |
| AU (1) | AU578395B2 (enExample) |
| CA (1) | CA1247101A (enExample) |
| DD (1) | DD239793A5 (enExample) |
| DE (2) | DE3442860A1 (enExample) |
| DK (1) | DK540585A (enExample) |
| ES (3) | ES8700253A1 (enExample) |
| FI (1) | FI854603A7 (enExample) |
| GR (1) | GR852813B (enExample) |
| HU (1) | HU195211B (enExample) |
| IL (1) | IL77124A (enExample) |
| NO (1) | NO164351C (enExample) |
| NZ (1) | NZ214289A (enExample) |
| PT (1) | PT81545B (enExample) |
| ZA (1) | ZA858418B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK93087A (da) * | 1986-02-27 | 1987-08-28 | Duphar Int Res | Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber |
| FR2648135B1 (fr) * | 1989-06-07 | 1991-09-27 | Pf Medicament | Derives de phenyl-1-dihydro-1,4 amino-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique |
| FR2676733B1 (fr) * | 1991-05-22 | 1993-10-01 | Fabre Medicament Pierre | Derives de phenyl-1 dihydro-1,4 hydroxy-3 oxo-4 pyridazines, leur preparation et leur application en therapeutique. |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| DK1531822T3 (da) * | 2002-06-12 | 2009-12-07 | Chemocentryx Inc | 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| AU2005219438B2 (en) * | 2004-03-03 | 2011-02-17 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US8927546B2 (en) * | 2006-02-28 | 2015-01-06 | Dart Neuroscience (Cayman) Ltd. | Therapeutic piperazines |
| US7829713B2 (en) * | 2006-02-28 | 2010-11-09 | Helicon Therapeutics, Inc. | Therapeutic piperazines |
| JP2008148592A (ja) * | 2006-12-15 | 2008-07-03 | Sk Sangyo Kk | 防風網 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3169966A (en) * | 1961-01-24 | 1965-02-16 | Ciba Geigy Corp | Aminopyrazoles |
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| IT1052130B (it) * | 1973-10-15 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
| DE3132916A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3132915A1 (de) * | 1981-08-20 | 1983-03-03 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1,5-diphenylpyrazolin-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
-
1984
- 1984-11-24 DE DE19843442860 patent/DE3442860A1/de not_active Withdrawn
-
1985
- 1985-11-01 ZA ZA858418A patent/ZA858418B/xx unknown
- 1985-11-14 AT AT85114466T patent/ATE50448T1/de not_active IP Right Cessation
- 1985-11-14 DE DE8585114466T patent/DE3576075D1/de not_active Expired - Lifetime
- 1985-11-14 EP EP85114466A patent/EP0185909B1/de not_active Expired - Lifetime
- 1985-11-20 HU HU854414A patent/HU195211B/hu not_active IP Right Cessation
- 1985-11-21 GR GR852813A patent/GR852813B/el unknown
- 1985-11-21 FI FI854603A patent/FI854603A7/fi not_active Application Discontinuation
- 1985-11-21 US US06/800,327 patent/US4672063A/en not_active Expired - Fee Related
- 1985-11-21 DD DD85283095A patent/DD239793A5/de not_active IP Right Cessation
- 1985-11-22 AU AU50350/85A patent/AU578395B2/en not_active Ceased
- 1985-11-22 PT PT81545A patent/PT81545B/pt not_active IP Right Cessation
- 1985-11-22 NO NO854677A patent/NO164351C/no unknown
- 1985-11-22 DK DK540585A patent/DK540585A/da not_active Application Discontinuation
- 1985-11-22 CA CA000496048A patent/CA1247101A/en not_active Expired
- 1985-11-22 IL IL77124A patent/IL77124A/xx unknown
- 1985-11-22 ES ES549176A patent/ES8700253A1/es not_active Expired
- 1985-11-22 NZ NZ214289A patent/NZ214289A/xx unknown
- 1985-11-25 JP JP60262725A patent/JPS61148164A/ja active Pending
-
1986
- 1986-05-16 ES ES555006A patent/ES8703869A1/es not_active Expired
- 1986-05-16 ES ES555007A patent/ES8703870A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8700253A1 (es) | 1986-10-01 |
| FI854603A0 (fi) | 1985-11-21 |
| ES8703869A1 (es) | 1987-03-01 |
| ES555007A0 (es) | 1987-03-01 |
| NZ214289A (en) | 1988-10-28 |
| IL77124A (en) | 1990-03-19 |
| US4672063A (en) | 1987-06-09 |
| EP0185909A1 (de) | 1986-07-02 |
| ES549176A0 (es) | 1986-10-01 |
| ES8703870A1 (es) | 1987-03-01 |
| IL77124A0 (en) | 1986-04-29 |
| HUT38927A (en) | 1986-07-28 |
| ES555006A0 (es) | 1987-03-01 |
| NO164351B (no) | 1990-06-18 |
| NO854677L (no) | 1986-05-26 |
| GR852813B (enExample) | 1986-03-21 |
| DE3442860A1 (de) | 1986-05-28 |
| PT81545B (pt) | 1988-01-22 |
| FI854603L (fi) | 1986-05-25 |
| AU5035085A (en) | 1986-07-17 |
| DK540585A (da) | 1986-05-25 |
| DD239793A5 (de) | 1986-10-08 |
| DE3576075D1 (de) | 1990-03-29 |
| HU195211B (en) | 1988-04-28 |
| ATE50448T1 (de) | 1990-03-15 |
| PT81545A (en) | 1985-12-01 |
| FI854603A7 (fi) | 1986-05-25 |
| AU578395B2 (en) | 1988-10-20 |
| JPS61148164A (ja) | 1986-07-05 |
| ZA858418B (en) | 1986-07-30 |
| NO164351C (no) | 1990-09-26 |
| DK540585D0 (da) | 1985-11-22 |
| EP0185909B1 (de) | 1990-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |