CA1243680A - Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors - Google Patents

Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors

Info

Publication number
CA1243680A
CA1243680A CA000448317A CA448317A CA1243680A CA 1243680 A CA1243680 A CA 1243680A CA 000448317 A CA000448317 A CA 000448317A CA 448317 A CA448317 A CA 448317A CA 1243680 A CA1243680 A CA 1243680A
Authority
CA
Canada
Prior art keywords
hydrogen
alkyl
accordance
compound
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000448317A
Other languages
English (en)
French (fr)
Inventor
George C. Rovnyak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1243680A publication Critical patent/CA1243680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000448317A 1983-03-24 1984-02-27 Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors Expired CA1243680A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US478,598 1983-03-24
US06/478,598 US4555579A (en) 1983-03-24 1983-03-24 Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors

Publications (1)

Publication Number Publication Date
CA1243680A true CA1243680A (en) 1988-10-25

Family

ID=23900577

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000448317A Expired CA1243680A (en) 1983-03-24 1984-02-27 Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors

Country Status (7)

Country Link
US (1) US4555579A (OSRAM)
JP (1) JPS59181289A (OSRAM)
CA (1) CA1243680A (OSRAM)
DE (1) DE3410847A1 (OSRAM)
FR (1) FR2543143B1 (OSRAM)
GB (1) GB2137625B (OSRAM)
IT (1) IT1173456B (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK302883D0 (da) * 1983-06-30 1983-06-30 Hans Bundgaard Allopurinol prodrugs
US4634689A (en) * 1985-10-31 1987-01-06 Schering Corporation Phosphinylalkanoyl imino acids
CZ63799A3 (cs) * 1996-08-28 1999-08-11 The Procter & Gamble Company Spirocyklické metalloproteázové inhibitory
MX2007008392A (es) * 2005-02-11 2007-09-06 Aventis Pharma Inc Esteres de acido propano-fosfinico sustituido.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4168267A (en) * 1978-10-23 1979-09-18 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl prolines
US4186268A (en) * 1979-01-29 1980-01-29 E. R. Squibb & Sons, Inc. Mercaptoacylpyrrolidine phosphonic acids and related compounds
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4379146A (en) * 1981-02-17 1983-04-05 Merck & Co., Inc. Substituted phosphonamides as antihypertensives
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4448772A (en) * 1982-04-22 1984-05-15 E. R. Squibb & Sons, Inc. Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4427665A (en) * 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions

Also Published As

Publication number Publication date
IT1173456B (it) 1987-06-24
IT8420168A0 (it) 1984-03-21
DE3410847A1 (de) 1984-09-27
FR2543143B1 (fr) 1986-12-05
FR2543143A1 (fr) 1984-09-28
GB2137625B (en) 1986-10-15
JPH047355B2 (OSRAM) 1992-02-10
GB2137625A (en) 1984-10-10
US4555579A (en) 1985-11-26
JPS59181289A (ja) 1984-10-15
GB8406522D0 (en) 1984-04-18
IT8420168A1 (it) 1985-09-21

Similar Documents

Publication Publication Date Title
EP0097050B1 (en) Esters of phosphinylalkanoyl substituted prolines
RU2266909C2 (ru) Водорастворимые азольные соединения и способ их получения
US5153347A (en) Phosphonate, phosphinate derivatives useful as antihypertensive agents
EP0099785B1 (en) Amino and substituted amino phosphinylalkanoyl compounds
EP0094687B1 (en) Phosphinylalkanoyl substituted imino acids
US4849525A (en) Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
GB2116559A (en) Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
GB2118944A (en) Phosphinylmethylaminocarbonyl imino acid compounds
EP0142335A2 (en) Lactam containing compounds
CA1243680A (en) Dioxolenylmethyl ester prodrugs of phosphinic acid ace inhibitors
CA2408941C (en) New process for the preparation of vinyl-pyrrolidinone cephalosporine derivatives
EP0130126B1 (en) (s)-9-(2,3-dihydroxy-1-propoxymethyl) guanine and its acyl derivatives, their preparation and their application as antiherpetic agents
EP0812846B1 (en) Preparation of cephem- and isooxacephem derivatives
WO1996026943A1 (en) Derivatives of 3-pyrrolidylidene-2-one-cephalosporines
KR100297180B1 (ko) 인지질유도체및이의제조방법
CA1187870A (en) Tripeptide inhibitors of angiotensin-converting enzyme
US5151521A (en) 1-aminoethyl phosphonic acid derivatives
US4377701A (en) 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
CA1137498A (en) Mercaptoacylpyrazolidinone carboxylic acid derivatives
US4880820A (en) Guanine derivatives
HRP970511A2 (en) 1-carba-(dethia)-cephalosporin derivatives
EP0237264A2 (en) Process for preparing phosphonyloxyacyl amino acids and derivates thereof
GB2139626A (en) Lactam containing compounds
KR19990036237A (ko) 1,9-디아자비시클록4.3.0 노나-3,8-디엔 유도체
JPS61180752A (ja) シンナムアミド安息香酸エステル

Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20051025