CA1242723A - Azoles, processes for their preparation and their use - Google Patents

Azoles, processes for their preparation and their use

Info

Publication number
CA1242723A
CA1242723A CA000449330A CA449330A CA1242723A CA 1242723 A CA1242723 A CA 1242723A CA 000449330 A CA000449330 A CA 000449330A CA 449330 A CA449330 A CA 449330A CA 1242723 A CA1242723 A CA 1242723A
Authority
CA
Canada
Prior art keywords
phenyl
substituted
halogen
heteroaryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000449330A
Other languages
English (en)
French (fr)
Inventor
Helmut Egger
Anton Stutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of CA1242723A publication Critical patent/CA1242723A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA000449330A 1983-03-11 1984-03-09 Azoles, processes for their preparation and their use Expired CA1242723A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1332/83 1983-03-11
CH1332/83A CH655103A5 (de) 1983-03-11 1983-03-11 Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.

Publications (1)

Publication Number Publication Date
CA1242723A true CA1242723A (en) 1988-10-04

Family

ID=4207992

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000449330A Expired CA1242723A (en) 1983-03-11 1984-03-09 Azoles, processes for their preparation and their use

Country Status (24)

Country Link
JP (1) JPS59175472A (fi)
KR (1) KR890000377B1 (fi)
AU (1) AU571494B2 (fi)
BE (1) BE899073A (fi)
CA (1) CA1242723A (fi)
CH (1) CH655103A5 (fi)
DE (1) DE3408127A1 (fi)
DK (1) DK149784A (fi)
ES (1) ES8506639A1 (fi)
FI (1) FI840968A (fi)
FR (1) FR2542315B1 (fi)
GB (1) GB2136801B (fi)
GR (1) GR81869B (fi)
HU (1) HUT36098A (fi)
IL (1) IL71203A (fi)
IT (1) IT1199085B (fi)
LU (1) LU85245A1 (fi)
NL (1) NL8400730A (fi)
NZ (1) NZ207453A (fi)
PH (1) PH24667A (fi)
PL (1) PL146072B1 (fi)
PT (1) PT78226B (fi)
SE (1) SE8401321L (fi)
ZA (1) ZA841782B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8618188D0 (en) * 1986-07-25 1986-09-03 Ici Plc Diamine compounds
DE3644615A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazol- und triazolderivate zur verwendung als antimykotische mittel
DE3644616A1 (de) * 1986-12-29 1988-07-07 Lentia Gmbh Imidazolderivate, verfahren zur herstellung und deren verwendung
US5252594A (en) * 1992-06-17 1993-10-12 Rohm And Haas Company Fungicidal (2-aryl-2-substituted)ethyl-1,2,4-triazoles
US5358939A (en) * 1992-06-25 1994-10-25 Rohm And Haas Company Fungicidal 2-aryl-2,2-disubstituted ethyl-1,2,4-triazoles
DE4412358A1 (de) * 1994-04-11 1995-10-12 Bayer Ag Cyclopropyl-ethyl-azole
GB9409882D0 (en) * 1994-05-18 1994-07-06 Sandoz Ltd Organic compounds
JP3214987B2 (ja) * 1994-09-05 2001-10-02 日本碍子株式会社 半導体装置およびその製造方法
US7125997B2 (en) * 2002-12-20 2006-10-24 Irm Llc Differential tumor cytotoxicity compounds and compositions
WO2004056744A1 (en) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
KR101192861B1 (ko) 2004-05-07 2012-10-19 얀센 파마슈티카 엔.브이. １１-베타 하이드록시스테로이드 탈수소효소 저해제로서의피롤리딘-２-온 및 피페리딘-２-온 유도체
JP5208505B2 (ja) 2004-08-30 2013-06-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ １１−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのｎ−２アダマンタニル−２−フェノキシ−アセトアミド誘導体
AU2005279209B2 (en) 2004-08-30 2011-03-24 Janssen Pharmaceutica N.V. Tricyclic lactam derivatives as 11-BETA hydroxysteroid dehydrogenase inhibitors
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
WO2006034338A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
WO2006034315A2 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
US7829712B2 (en) 2004-09-20 2010-11-09 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase
BRPI0515488A (pt) 2004-09-20 2008-07-29 Xenon Pharmaceuticals Inc derivados de heterocìclicos e seu uso como agentes terapêuticos
BRPI0515482A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos e seus usos como agentes terapêuticos
TW200624427A (en) 2004-09-20 2006-07-16 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
CN101083994A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途
BRPI0611187A2 (pt) 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
CN104530038A (zh) * 2014-12-10 2015-04-22 沈阳药科大学 酰胺咪唑类衍生物及其用途
CN112142673B (zh) * 2020-09-18 2023-06-30 聊城大学 芳基烯烃唑类衍生物及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU557755A3 (ru) * 1968-08-19 1977-05-05 Янссен Фармасьютика Н.В. (Фирма) Способ получени производных имидазола
CA1189857A (en) * 1981-03-27 1985-07-02 Janssen Pharmaceutica Naamloze Vennootschap Antimicrobial triazole derivatives
AU8314482A (en) * 1981-05-19 1982-11-25 Imperial Chemical Industries Plc 3-triazolyl(imidazolyl)-2,2 bis phenyl-propionamides
EP0117462A3 (en) * 1983-02-28 1986-08-20 American Cyanamid Company N-(2-4-(1h-imidazol-1-yl)alkyl)arylamides

Also Published As

Publication number Publication date
FR2542315B1 (fr) 1986-02-07
KR890000377B1 (ko) 1989-03-15
DK149784A (da) 1984-09-12
NZ207453A (en) 1987-09-30
BE899073A (fr) 1984-09-05
LU85245A1 (fr) 1984-11-14
GB2136801B (en) 1987-03-04
PT78226B (en) 1986-07-15
PH24667A (en) 1990-09-07
ES530461A0 (es) 1985-07-16
AU571494B2 (en) 1988-04-21
KR850006386A (ko) 1985-10-05
IL71203A (en) 1988-10-31
ZA841782B (en) 1985-10-30
HUT36098A (en) 1985-08-28
AU2547584A (en) 1984-09-13
IT1199085B (it) 1988-12-30
ES8506639A1 (es) 1985-07-16
FR2542315A1 (fr) 1984-09-14
PL146072B1 (en) 1988-12-31
DE3408127A1 (de) 1984-09-13
IT8447817A0 (it) 1984-03-08
CH655103A5 (de) 1986-03-27
SE8401321D0 (sv) 1984-03-09
JPS59175472A (ja) 1984-10-04
PL246600A1 (en) 1985-03-12
PT78226A (en) 1984-04-01
GB2136801A (en) 1984-09-26
GR81869B (fi) 1984-12-12
DK149784D0 (da) 1984-02-29
NL8400730A (nl) 1984-10-01
FI840968A (fi) 1984-09-12
GB8405900D0 (en) 1984-04-11
SE8401321L (sv) 1984-09-12
IL71203A0 (en) 1984-06-29
FI840968A0 (fi) 1984-03-09

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Legal Events

Date Code Title Description
MKEX Expiry