CA1240321A - Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin - Google Patents

Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin

Info

Publication number
CA1240321A
CA1240321A CA000474602A CA474602A CA1240321A CA 1240321 A CA1240321 A CA 1240321A CA 000474602 A CA000474602 A CA 000474602A CA 474602 A CA474602 A CA 474602A CA 1240321 A CA1240321 A CA 1240321A
Authority
CA
Canada
Prior art keywords
weight
alkali metal
metal hydroxide
hydroxide
basic medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000474602A
Other languages
English (en)
French (fr)
Inventor
Masaaki Azuma
Takehisa Ohashi
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12397654&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1240321(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Application granted granted Critical
Publication of CA1240321A publication Critical patent/CA1240321A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA000474602A 1984-02-23 1985-02-19 Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin Expired CA1240321A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59033839A JPS60178887A (ja) 1984-02-23 1984-02-23 ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JP33839/1984 1984-02-23

Publications (1)

Publication Number Publication Date
CA1240321A true CA1240321A (en) 1988-08-09

Family

ID=12397654

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000474602A Expired CA1240321A (en) 1984-02-23 1985-02-19 Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin

Country Status (7)

Country Link
US (1) US4595752A (esLanguage)
EP (1) EP0153696B1 (esLanguage)
JP (1) JPS60178887A (esLanguage)
AT (1) ATE46906T1 (esLanguage)
CA (1) CA1240321A (esLanguage)
DE (1) DE3573426D1 (esLanguage)
ES (1) ES8601993A1 (esLanguage)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS60199889A (ja) * 1984-03-24 1985-10-09 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−エリスロ−ビオプテリンの硫酸塩およびその製法
JPS60204786A (ja) * 1984-03-29 1985-10-16 Univ Nagoya （６ｒ）―テトラヒドロビオプテリンの合成法
US4665176A (en) * 1984-10-23 1987-05-12 Mitsui Toatsu Chemicals, Incorporated Process for the preparation of 5,6,7,8-tetrahydrofolic acid
CA1262347A (en) * 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
DE3853711T2 (de) * 1987-11-30 1996-01-11 Vitamin Kenkyusho Kk Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
IL154530A0 (en) 2000-08-31 2003-09-17 Suntory Ltd Process for production of biopterin compound
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
AU2004291149C1 (en) 2003-11-17 2021-01-21 Biomarin Pharmaceutical Inc. Methods and Compositions for the Treatment of Metabolic Disorders
AU2004311544A1 (en) * 2003-11-17 2005-07-21 Merck & Cie Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
CA2601716C (en) * 2004-06-25 2011-05-31 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of attention deficit hyperactivity disorder and hyperphenylalanemia
EP2436379A1 (en) 2004-11-17 2012-04-04 BioMarin Pharmaceutical Inc. Stable tablet formulation
WO2006063215A2 (en) * 2004-12-08 2006-06-15 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
BRPI0608863B1 (pt) 2005-04-14 2022-09-27 Shiratori Pharmaceutical Co., Ltd. Método para produzir cristais de cloridrato de sapropterina na forma alfa
CA2631740A1 (en) * 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
WO2008089148A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
CA2675134A1 (en) * 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Pterin analogs
KR20100016445A (ko) 2007-04-11 2010-02-12 바이오마린 파머수티컬 인크. 테트라하이드로바이오프테린 투여 방법, 관련 조성물 및 측정 방법
JP2011508775A (ja) * 2008-01-03 2011-03-17 ビオマリン プハルマセウトイカル インコーポレイテッド Ｂｈ４応答性状態を治療するためのプテリン類似体
WO2009088979A1 (en) * 2008-01-07 2009-07-16 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
CN102443006B (zh) 2010-10-13 2016-02-24 因华生技制药股份有限公司 (6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) * 2010-10-15 2015-04-21 Innopharmax Inc （６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) * 2012-04-10 2014-04-16 凯莱英医药集团（天津）股份有限公司 一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) * 2012-04-10 2014-06-25 凯莱英医药集团（天津）股份有限公司 一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
WO2016189542A1 (en) 2015-05-28 2016-12-01 Natco Pharma Ltd Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2741608A (en) * 1951-03-08 1956-04-10 Research Corp 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same
JPS5883691A (ja) * 1981-11-13 1983-05-19 Kanegafuchi Chem Ind Co Ltd １′，２′−ジアシル−（６ｒ，ｓ）−５，６，７，８−テトラヒドロ−ｌ−ビオプテリンおよびその製法
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS61172876A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
JPS61172877A (ja) * 1985-01-28 1986-08-04 Shiratori Seiyaku Kk （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法

Also Published As

Publication number Publication date
JPH0212475B2 (esLanguage) 1990-03-20
EP0153696A2 (en) 1985-09-04
EP0153696B1 (en) 1989-10-04
ES540638A0 (es) 1985-11-16
EP0153696A3 (en) 1987-08-19
DE3573426D1 (en) 1989-11-09
ATE46906T1 (de) 1989-10-15
JPS60178887A (ja) 1985-09-12
US4595752A (en) 1986-06-17
ES8601993A1 (es) 1985-11-16

Similar Documents

Publication Publication Date Title
CA1240321A (en) Process for preparing 5,6,7,8-tetrahydro-6-(l-erythro- 1',2'-dihydroxypropyl)pterin
US4713454A (en) Preparation process of (6R)-tetrahydro-L-biopterin
JPH1067701A (ja) マロン酸またはその塩の製造方法
US4148999A (en) Preparation and purification of citrovorum factor
US4649197A (en) Sulfate of 5,6,7,8-tetrahydro-L-erythro-biopterin and process for preparing the same
EP1153910B1 (en) Process for the preparation of (2r)-2-propyloctanoic acid
Hockett et al. Improvements in the Preparation of d-Arabinose from Calcium Gluconate1
CA1282420C (en) Process for producing 2-methyl-1,4-naphthoquinone
US3019260A (en) Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
JPH1072401A (ja) ３−ヒドロキシプロピオン酸またはその塩の製造方法
US4610828A (en) Process for preparing L-carnitine and salts thereof
JPS60204786A (ja) （６ｒ）―テトラヒドロビオプテリンの合成法
US4206307A (en) Preparation of tetrahydrofolic acid from folic acid
JP3716376B2 (ja) 光学分割剤およびそれを用いた光学活性３−アミノピロリジン誘導体の製造法
Maleski Improved procedures for the preparation of 2-nitro-5-methoxyphenol and 6-methoxy-2 (3H)-benzoxazolone from 3-methoxyphenol
JP3066423B2 (ja) β−ヒドロキシエトキシ酢酸の製造方法
US3146265A (en) 6-deoxy-6-hydroperoxy dehydrotetracyclines and process utilizing the same
US20060069289A1 (en) Process for production 2-deoxyaldose compound
JPS61172877A (ja) （６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法
EP1249449B1 (en) Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan
CN1036386A (zh) D-氨基半乳糖盐酸盐的制备方法
JPH05255301A (ja) ６−ヒドロキシ−２，５，７，８−テトラアルキル−２−（４−アミノフェノキシメチル）クロマンの製造方法
JP3685511B2 (ja) オキシ酢酸水溶液の精製方法
Muscio Jr et al. Hydrolyses of 2-and 4-fluoro N-heterocycles. 2. Nucleophilic catalysis by buffer bases in the hydrolysis of 2-fluoro-1-methylpyridinium iodide
SU454763A1 (ru) Способ получени катализатора дл разложени муравьиной кислоты

Legal Events

Date Code Title Description
MKEX Expiry
MKEX Expiry

Effective date: 20050809