CA1238903A - Processes for preparation, isolation and purification of dipeptide sweeteners - Google Patents

Processes for preparation, isolation and purification of dipeptide sweeteners

Info

Publication number
CA1238903A
CA1238903A CA000410725A CA410725A CA1238903A CA 1238903 A CA1238903 A CA 1238903A CA 000410725 A CA000410725 A CA 000410725A CA 410725 A CA410725 A CA 410725A CA 1238903 A CA1238903 A CA 1238903A
Authority
CA
Canada
Prior art keywords
acid
aspartyl
hydrogen
methyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000410725A
Other languages
English (en)
French (fr)
Inventor
Constantine Sklavounos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Danisco Cultor America Inc
Original Assignee
Pfizer Ltd Great Britain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain
Application granted granted Critical
Publication of CA1238903A publication Critical patent/CA1238903A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Joints Allowing Movement (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Detergent Compositions (AREA)
  • Discharging, Photosensitive Material Shape In Electrophotography (AREA)
  • Manufacturing Of Electrical Connectors (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
CA000410725A 1981-09-08 1982-09-03 Processes for preparation, isolation and purification of dipeptide sweeteners Expired CA1238903A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/300,366 US4375430A (en) 1981-09-08 1981-09-08 Processes for preparation, isolation and purification of dipeptide sweeteners
US300,366 1981-09-08

Publications (1)

Publication Number Publication Date
CA1238903A true CA1238903A (en) 1988-07-05

Family

ID=23158792

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000410725A Expired CA1238903A (en) 1981-09-08 1982-09-03 Processes for preparation, isolation and purification of dipeptide sweeteners

Country Status (19)

Country Link
US (1) US4375430A (oth)
EP (1) EP0074249B1 (oth)
JP (1) JPS5857350A (oth)
AT (1) ATE8879T1 (oth)
AU (1) AU534082B2 (oth)
CA (1) CA1238903A (oth)
DE (1) DE3260543D1 (oth)
DK (1) DK155947C (oth)
ES (3) ES8308304A1 (oth)
FI (1) FI76352C (oth)
GR (1) GR76704B (oth)
IE (1) IE53795B1 (oth)
IL (1) IL66739A (oth)
MX (1) MX155762A (oth)
NO (1) NO161123C (oth)
NZ (1) NZ201816A (oth)
PT (1) PT75519B (oth)
YU (1) YU43277B (oth)
ZA (1) ZA826522B (oth)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855454A (en) * 1980-01-21 1989-08-08 Pfizer Inc. Branched amides of L-aspartyl-D-amino acid dipeptides
US4465626A (en) * 1981-09-08 1984-08-14 Pfizer Inc. Process for preparation, isolation and purification of dipeptide sweeteners
CA1276395C (en) * 1984-07-13 1990-11-13 John M. Janusz Oxa-fenchyl esters and amides of alpha-l-aspartyl-d- phenylglycine
CA1276394C (en) * 1984-07-13 1990-11-13 John M. Janusz Alpha-l-aspartyl-d-phenylglycine esters and amides useful as high intensity sweeteners
US4572799A (en) * 1985-04-15 1986-02-25 General Foods Corporation L-Aminodicarboxylic acid amides
EP0199257A3 (en) * 1985-04-15 1988-08-10 General Foods Corporation L-aminodicarboxylic acid esters and an edible composition containing same as sweeteners
US4935355A (en) * 1986-04-15 1990-06-19 Synthetech, Inc. Preparation of dipeptides
US4758443A (en) * 1986-06-18 1988-07-19 General Foods Corporation Thietanyl-substituted amides and use thereof as sweeteners
US4855455A (en) * 1988-01-22 1989-08-08 W. R. Grace & Co.-Conn. Preparation of amino acid derivatives
US5283357A (en) * 1988-03-14 1994-02-01 Mitsui Toatsu Chemicals, Incorporated Separation method of α-l-aspartyl-l-phenylalanine methyl ester
WO2006042678A1 (de) * 2004-10-14 2006-04-27 Wilex Ag Verfahren zur reinigung von 3-hydroxy-amidino-phenylalanin-derivaten durch ausfällung und umkristallisation eines salzes mit einer aromatischen sulfonsäure

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA909254A (en) * 1969-12-30 1972-09-05 Ariyoshi Yasuo METHOD OF PURIFYING LOWER ALKYL OF .alpha.-L-ASPARTYL-L-PHENYLALANINE

Also Published As

Publication number Publication date
ES521764A0 (es) 1984-07-01
JPS6318959B2 (oth) 1988-04-20
FI76352C (fi) 1988-10-10
MX155762A (es) 1988-04-25
PT75519A (en) 1982-10-01
IE53795B1 (en) 1989-02-15
DK155947C (da) 1989-11-13
DE3260543D1 (en) 1984-09-13
DK155947B (da) 1989-06-05
IL66739A (en) 1985-07-31
ES8406063A1 (es) 1984-07-01
JPS5857350A (ja) 1983-04-05
FI76352B (fi) 1988-06-30
YU43277B (en) 1989-06-30
EP0074249B1 (en) 1984-08-08
NO823002L (no) 1983-03-09
ES515545A0 (es) 1983-08-16
ATE8879T1 (de) 1984-08-15
ZA826522B (en) 1983-07-27
YU201382A (en) 1985-04-30
GR76704B (oth) 1984-08-29
EP0074249A1 (en) 1983-03-16
AU8808782A (en) 1983-05-05
NZ201816A (en) 1985-05-31
FI823072L (fi) 1983-03-09
US4375430A (en) 1983-03-01
IE822175L (en) 1983-03-08
AU534082B2 (en) 1984-01-05
PT75519B (en) 1985-11-25
IL66739A0 (en) 1982-12-31
NO161123C (no) 1989-07-05
ES8308304A1 (es) 1983-08-16
ES521765A0 (es) 1984-07-01
DK399182A (da) 1983-03-09
FI823072A0 (fi) 1982-09-06
NO161123B (no) 1989-03-28
ES8406064A1 (es) 1984-07-01

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