CA1229791A - Composition medicamenteuse a base de fragments fc d'igg humaines - Google Patents
Composition medicamenteuse a base de fragments fc d'igg humainesInfo
- Publication number
- CA1229791A CA1229791A CA000469658A CA469658A CA1229791A CA 1229791 A CA1229791 A CA 1229791A CA 000469658 A CA000469658 A CA 000469658A CA 469658 A CA469658 A CA 469658A CA 1229791 A CA1229791 A CA 1229791A
- Authority
- CA
- Canada
- Prior art keywords
- fragments
- cells
- igg
- fab
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 title claims abstract description 41
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims description 13
- 229940079593 drug Drugs 0.000 title abstract description 10
- 239000003814 drug Substances 0.000 title abstract description 10
- 210000004027 cell Anatomy 0.000 claims abstract description 102
- 239000012634 fragment Substances 0.000 claims abstract description 53
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims abstract description 15
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims abstract description 15
- 230000003013 cytotoxicity Effects 0.000 claims abstract description 13
- 231100000135 cytotoxicity Toxicity 0.000 claims abstract description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 10
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- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 7
- 230000004069 differentiation Effects 0.000 claims abstract description 3
- 210000000822 natural killer cell Anatomy 0.000 claims abstract description 3
- 239000004480 active ingredient Substances 0.000 claims description 10
- 239000012190 activator Substances 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 210000004698 lymphocyte Anatomy 0.000 description 37
- 238000000034 method Methods 0.000 description 34
- 230000000694 effects Effects 0.000 description 29
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- VYZAMTAEIAYCRO-BJUDXGSMSA-N Chromium-51 Chemical compound [51Cr] VYZAMTAEIAYCRO-BJUDXGSMSA-N 0.000 description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
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- 238000000338 in vitro Methods 0.000 description 4
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- 108010058597 HLA-DR Antigens Proteins 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
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- 108010074605 gamma-Globulins Proteins 0.000 description 3
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- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical compound [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 3
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- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
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- 206010070834 Sensitisation Diseases 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
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- 229960004857 mitomycin Drugs 0.000 description 2
- 238000007799 mixed lymphocyte reaction assay Methods 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229940055729 papain Drugs 0.000 description 2
- 235000019834 papain Nutrition 0.000 description 2
- 210000005259 peripheral blood Anatomy 0.000 description 2
- 239000011886 peripheral blood Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 238000011533 pre-incubation Methods 0.000 description 2
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- 230000008313 sensitization Effects 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- RWBLWXCGQLZKLK-USVTTYPOSA-N (2s)-2-[(2-aminoacetyl)amino]-n-[(2s)-1-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[2-[[(2s)-1-[[(2s)-1-[[(2s)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxob Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(N)=O)NC(=O)CN)C(C)C)C1=CN=CN1 RWBLWXCGQLZKLK-USVTTYPOSA-N 0.000 description 1
- IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 1
- IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 241000272814 Anser sp. Species 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 101100012466 Drosophila melanogaster Sras gene Proteins 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- KOGVDCPMCJJZTB-UHFFFAOYSA-N INNI Chemical compound INNI KOGVDCPMCJJZTB-UHFFFAOYSA-N 0.000 description 1
- 229930192392 Mitomycin Natural products 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101000579608 Nicotiana tabacum Probable U6 snRNA-associated Sm-like protein LSm4 Proteins 0.000 description 1
- RSPISYXLHRIGJD-UHFFFAOYSA-N OOOO Chemical compound OOOO RSPISYXLHRIGJD-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 108010033737 Pokeweed Mitogens Proteins 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
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- 241000473945 Theria <moth genus> Species 0.000 description 1
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 1
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- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 239000001166 ammonium sulphate Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000781 anti-lymphocytic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
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- 230000002519 immonomodulatory effect Effects 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
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- 239000011630 iodine Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 230000037125 natural defense Effects 0.000 description 1
- 230000031942 natural killer cell mediated cytotoxicity Effects 0.000 description 1
- 229940043515 other immunoglobulins in atc Drugs 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000020004 porter Nutrition 0.000 description 1
- 230000001698 pyrogenic effect Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
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- 238000011105 stabilization Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR83.19568 | 1983-12-07 | ||
| FR8319568A FR2556219B1 (fr) | 1983-12-07 | 1983-12-07 | Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1229791A true CA1229791A (fr) | 1987-12-01 |
Family
ID=9294941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000469658A Expired CA1229791A (fr) | 1983-12-07 | 1984-12-07 | Composition medicamenteuse a base de fragments fc d'igg humaines |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4719107A (enExample) |
| EP (1) | EP0147283B1 (enExample) |
| JP (1) | JPS60185726A (enExample) |
| AT (1) | ATE45498T1 (enExample) |
| CA (1) | CA1229791A (enExample) |
| DE (3) | DE3479398D1 (enExample) |
| FR (1) | FR2556219B1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62153300A (ja) * | 1985-12-26 | 1987-07-08 | Teijin Ltd | ヒト免疫グロブリンＧＦｃ領域蛋白質およびその製造方法 |
| US4925920A (en) * | 1987-05-29 | 1990-05-15 | Brigham And Women's Hospital | Immunosuppressive polypeptides |
| US4814433A (en) * | 1987-09-16 | 1989-03-21 | Miles Inc. | Method for obtaining a papain-free antibody fragment preparation |
| US5681566A (en) * | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
| GB8824869D0 (en) * | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
| FR2639231A1 (fr) * | 1988-11-23 | 1990-05-25 | Merieux Inst | Utilisation de fragments fc d'immunoglobulines g humaines, de peptides analogues du fragment fc, ou d'immunoglobulines g humaines dans l'obtention d'un medicament preparatoire a l'administration chez l'homme, dans un but therapeutique ou de diagnostic, d'anticorps monoclonaux |
| US5328834A (en) * | 1989-09-08 | 1994-07-12 | Unisyn Technologies, Inc. | Method for preparing immunoglobulin fragments |
| GB9009106D0 (en) * | 1990-04-23 | 1990-06-20 | 3I Res Expl Ltd | Processes and intermediates for synthetic antibody derivatives |
| US5230887A (en) * | 1990-07-11 | 1993-07-27 | Immune Network Research Ltd. | Immune system stabilizers for prevention and therapy of disorders associated with immune system disfunction |
| US5219578A (en) * | 1991-02-25 | 1993-06-15 | Innovet, Inc. | Composition and method for immunostimulation in mammals |
| US7425331B2 (en) * | 2002-04-10 | 2008-09-16 | Protalex, Inc. | Protein A methods of use |
| US7211258B2 (en) * | 2002-04-10 | 2007-05-01 | Protalex, Inc. | Protein A compositions and methods of use |
| AU2004247021A1 (en) * | 2003-05-16 | 2004-12-23 | Acorda Therapeutics | Compositions and methods including a recombinant human MAB that promotes CNS remyelination |
| DE602004031772D1 (de) * | 2003-12-04 | 2011-04-21 | Abbott Biotherapeutics Corp | Anti-ip-10-antikörper |
| US20080206246A1 (en) * | 2006-04-05 | 2008-08-28 | Ravetch Jeffrey V | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| WO2007055916A2 (en) * | 2005-11-07 | 2007-05-18 | The Rockefeller University | Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof |
| US8470318B2 (en) * | 2005-11-07 | 2013-06-25 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| US10167332B2 (en) * | 2006-04-05 | 2019-01-01 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| JP4866467B2 (ja) | 2007-01-30 | 2012-02-01 | エピバックス インコーポレーテッド | 調節性ｔ細胞エピトープ、組成物およびその使用 |
| US20110150867A1 (en) * | 2007-12-14 | 2011-06-23 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| MX2010011598A (es) * | 2008-04-22 | 2010-12-15 | Univ Rockefeller | Metodos para identificar compuestos anti-inflamatorios. |
| SG10201913507SA (en) | 2014-05-02 | 2020-02-27 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| ES2972740T3 (es) | 2016-03-02 | 2024-06-14 | Momenta Pharmaceuticals Inc | Procedimientos relacionados con construcciones de Fc modificadas genéticamente |
| NZ749292A (en) | 2016-05-23 | 2025-08-29 | Momenta Pharmaceuticals Inc | Compositions and methods related to engineered fc constructs |
| CN110650748B (zh) | 2017-01-06 | 2024-01-02 | 动量制药公司 | 与经工程改造的Fc构建体相关的组合物和方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2222083B1 (enExample) * | 1973-03-22 | 1976-05-14 | Fontaine Michel | |
| FR2267115B1 (enExample) * | 1974-04-12 | 1977-11-10 | Merieux Inst | |
| DE2846412A1 (de) * | 1978-10-25 | 1980-05-08 | Behringwerke Ag | Mittel zur behandlung allergischer reaktionen |
| DE2853453A1 (de) * | 1978-12-11 | 1980-06-19 | Behringwerke Ag | Mittel zur therapie von immunkomplexerkrankungen |
| JPS5821623A (ja) * | 1981-07-28 | 1983-02-08 | Tetsuzo Sugizaki | 抗原抗体複合体沈着疾患治療剤 |
| JPS5821624A (ja) * | 1982-04-06 | 1983-02-08 | Tetsuzo Sugizaki | 慢性関節リウマチの治療剤 |
| EP0091760B1 (en) * | 1982-04-09 | 1986-07-02 | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. | Anti immune complex antibody and preparation thereof |
| US4465670A (en) * | 1982-07-23 | 1984-08-14 | Dainippon Pharmaceutical Co., Ltd. | Method for the treatment of systemic lupus erythematosus and primary glomerulonephritis and agent therefor |
-
1983
- 1983-12-07 FR FR8319568A patent/FR2556219B1/fr not_active Expired
-
1984
- 1984-12-07 CA CA000469658A patent/CA1229791A/fr not_active Expired
- 1984-12-07 AT AT84402531T patent/ATE45498T1/de active
- 1984-12-07 DE DE8484402531T patent/DE3479398D1/de not_active Expired
- 1984-12-07 DE DE198484402531T patent/DE147283T1/de active Pending
- 1984-12-07 JP JP59259048A patent/JPS60185726A/ja active Granted
- 1984-12-07 EP EP84402531A patent/EP0147283B1/fr not_active Expired
- 1984-12-07 US US06/679,445 patent/US4719107A/en not_active Expired - Fee Related
- 1984-12-07 DE DE19843444765 patent/DE3444765A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0586378B2 (enExample) | 1993-12-10 |
| DE3444765A1 (de) | 1985-06-20 |
| EP0147283B1 (fr) | 1989-08-16 |
| FR2556219B1 (fr) | 1987-06-26 |
| DE147283T1 (de) | 1986-04-10 |
| EP0147283A3 (en) | 1985-08-14 |
| JPS60185726A (ja) | 1985-09-21 |
| US4719107A (en) | 1988-01-12 |
| EP0147283A2 (fr) | 1985-07-03 |
| FR2556219A1 (fr) | 1985-06-14 |
| ATE45498T1 (de) | 1989-09-15 |
| DE3479398D1 (en) | 1989-09-21 |
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