CA1208129A - Surfactant and pharmaceutical compositions containing same - Google Patents

Surfactant and pharmaceutical compositions containing same

Info

Publication number
CA1208129A
CA1208129A CA000449223A CA449223A CA1208129A CA 1208129 A CA1208129 A CA 1208129A CA 000449223 A CA000449223 A CA 000449223A CA 449223 A CA449223 A CA 449223A CA 1208129 A CA1208129 A CA 1208129A
Authority
CA
Canada
Prior art keywords
surfactant
surface tension
phosphocholine
dynes
lipoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000449223A
Other languages
English (en)
French (fr)
Inventor
Takei Tsunetomo
Tanaka Yuji
Masuda Kazuo
Kanazawa Yosaku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12518415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA1208129(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Application granted granted Critical
Publication of CA1208129A publication Critical patent/CA1208129A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Otolaryngology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
CA000449223A 1983-03-10 1984-03-09 Surfactant and pharmaceutical compositions containing same Expired CA1208129A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58038189A JPS59164724A (ja) 1983-03-10 1983-03-10 サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
JP38,189/1983 1983-03-10

Publications (1)

Publication Number Publication Date
CA1208129A true CA1208129A (en) 1986-07-22

Family

ID=12518415

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000449223A Expired CA1208129A (en) 1983-03-10 1984-03-09 Surfactant and pharmaceutical compositions containing same

Country Status (10)

Country Link
US (1) US4603124A (enExample)
EP (1) EP0119056B1 (enExample)
JP (1) JPS59164724A (enExample)
AT (1) ATE55908T1 (enExample)
AU (1) AU562676B2 (enExample)
CA (1) CA1208129A (enExample)
DE (1) DE3483055D1 (enExample)
GR (1) GR81930B (enExample)
IE (1) IE57006B1 (enExample)
MX (1) MX9203493A (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430020A (en) * 1984-12-11 1995-07-04 Scios Nova Inc. Recombinant alveolar surfactant protein
US5110806A (en) * 1985-06-26 1992-05-05 The Regents Of The University Of California Lung surfactant compositions
DE3528934A1 (de) * 1985-08-13 1987-02-26 Feldmuehle Ag Gleitelement aus keramischem werkstoff
EP0240550A4 (en) * 1985-09-26 1989-09-19 Genetics Inst TENSIO-ACTIVE PULMONARY PROTEINS.
US5256569A (en) * 1986-01-21 1993-10-26 Chisso Corporation Transesterification process for otereoselection of enantiomers of secondary alcohols using pseudomonas lipase with no added solvent
IT1203873B (it) * 1987-04-08 1989-02-23 Chiesi Farma Spa Composizioni farmaceutiche che lo surfattante polmonare naturale, contengono. metodo di preparazione e
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
DE3921954A1 (de) * 1989-07-04 1991-01-17 Thomae Gmbh Dr K Niedrig-viskose, hochkonzentrierte surfactant-suspension
US5174988A (en) * 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
US5207220A (en) * 1989-12-12 1993-05-04 Burroughs Wellcome Co. Method for administering pharmaceuticals, including liquid surfactant, to the lungs
FR2658418B1 (fr) * 1990-02-20 1994-09-02 Synthelabo Compositions pharmaceutiques a base de phospholipides.
DE69131163T2 (de) * 1990-05-18 1999-12-23 Tokyo Tanabe Co., Ltd. Asthma heilmittel
US5614216A (en) * 1990-10-17 1997-03-25 The Liposome Company, Inc. Synthetic lung surfactant
JP3961029B2 (ja) * 1992-06-24 2007-08-15 博 木戸 インフルエンザウィルス感染防止剤
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
CO5021218A1 (es) * 1994-12-29 2001-03-27 Ct Nac De Sanidad Agropecuaria Surfactante pulmonar natural porcino
US6129934A (en) * 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
DK0877602T3 (da) 1996-01-24 2002-05-06 Byk Gulden Lomberg Chem Fab Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater
US6172203B1 (en) * 1996-02-07 2001-01-09 Alfredo Adolfo Hager Method for extracting and purifying pulmonary surfactant
AU2322097A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US5667948A (en) * 1996-04-16 1997-09-16 Eastman Kodak Company Processing silver halide films with an aqueous phospholipid rinse solution
DE69811407T2 (de) 1997-12-24 2003-11-20 Britannia Pharmaceuticals Ltd., Redhill Verwendung eines oberflächenaktiven mittels zur herstellung eines arzneimittels zur behandlung von erkrankungen des mittelohrs
WO2001019392A1 (en) 1999-09-16 2001-03-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Combination of c1-inh and lung surfactant for the treatment of respiratory disorders
DE10018022A1 (de) * 2000-04-12 2001-10-31 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen
GB0026239D0 (en) * 2000-10-26 2000-12-13 Britannia Pharmaceuticals Ltd Surface active lipids in treatment of wet lung
US20040241744A1 (en) * 2001-07-12 2004-12-02 Hiroaki Kohno Method of quantifying denatured lipoprotein, reagents for quantifying denatured lipoprotein, method of detecting circulatory disease and reagents for detecting circulatory disease
JP4559731B2 (ja) 2001-10-11 2010-10-13 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 肺サーファクタントの新規使用
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
ES2339954T3 (es) 2004-08-06 2010-05-27 Nycomed Gmbh Composicion que comprende un agente tensioactivo pulmonar y un peptido derivado de tnf.
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
CN102271666A (zh) 2008-12-10 2011-12-07 Paka肺部医药公司 用于向肺脏递送药物的方法和组合物
NZ607358A (en) 2010-08-23 2015-04-24 Takeda Gmbh Humidified particles comprising a therapeutically active substance
DK2723323T3 (en) * 2012-03-28 2016-01-11 Discovery Lab Inc FREEZE DRYING OF SYNTHETIC liposomal pulmonary surfactant

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE388023C (de) * 1922-02-14 1924-01-07 Chem Fab Verfahren zur Herstellung von waesserigen Lezithinemulsionen
FR2343481A1 (fr) * 1976-03-11 1977-10-07 Gerlich Norbert Composition destinee a empecher les lesions des membranes biologiques et a regenerer ces membranes une fois qu'elles ont ete endommagees
DE2900300A1 (de) * 1979-01-05 1980-07-17 Lebrecht Von Dr Klitzing Verfahren einer prophylaxe zur vermeidung des atemnotsyndroms bei fruehgeborenen und bei der schocklunge
JPS55160721A (en) * 1979-06-02 1980-12-13 Tokyo Tanabe Co Ltd Pulmonary surfactant ta-546, its preparation, and remedy for pulmonary hyaline membrane syndrome comprising it as active constituent
US4312860A (en) * 1980-10-24 1982-01-26 Regents Of The University Of California Lung surfactant compositions
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤

Also Published As

Publication number Publication date
IE840553L (en) 1984-09-10
AU2512584A (en) 1984-09-13
JPH0378371B2 (enExample) 1991-12-13
JPS59164724A (ja) 1984-09-17
EP0119056A2 (en) 1984-09-19
GR81930B (enExample) 1984-12-12
AU562676B2 (en) 1987-06-18
MX9203493A (es) 1992-08-01
IE57006B1 (en) 1992-03-11
US4603124A (en) 1986-07-29
ATE55908T1 (de) 1990-09-15
EP0119056A3 (en) 1986-06-25
EP0119056B1 (en) 1990-08-29
DE3483055D1 (de) 1990-10-04

Similar Documents

Publication Publication Date Title
CA1208129A (en) Surfactant and pharmaceutical compositions containing same
DE68929287T2 (de) Oberflächenaktives Lungenprotein und verwandte Polypeptide
DE68917603T2 (de) Verabreichung von arzneimitteln über die lungen.
Taeusch et al. Characterization of bovine surfactant for infants with respiratory distress syndrome
DE69232760T2 (de) Synthetische pulmonäre oberflächenaktive peptide
US4338301A (en) Lung tissue extract useful for treating hyaline-membrane disease and method for producing the extract
DE69835594T2 (de) Zusammensetzungen zur behandlung von irds oder ards die 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamid und lungensurfactant enthalten
US4397839A (en) Surface active material and process for preparing same
NZ280420A (en) Intravenous staurosporine compositions
DE69432313T2 (de) Neuartiges sythetisches Peptil, diese enthaltende Zusammensetzung und Arznei-Zusammensetzung und Arznei gegen das Atemnotsyndrom
CA2138281A1 (en) Prophylactic and remedy for viral diseases in respiratory tract
EP1506234B1 (en) Improved synthetic lipid mixtures for the preparation of a reconstituted surfactant
DE69928279T2 (de) Lungensurfactant zubereitungen enthaltendes behandlungset
DE69132211T2 (de) Synthetische oberflächenaktive agentien auf der lunge
DE60217060T2 (de) Pharmazeutische Zusammensetzungen, die Lungensurfactants und ein Polymyxin umfassen und verbesserte Oberflächenspannung-senkende Eigenschaften haben
EP0598116B1 (en) Fat emulsion
DE69710996T2 (de) Liposomale Zusammensetzung mit dem menschlichen Calcitonin Gene-Related Peptide und deren Herstellung
NZ242869A (en) Treatment of diseases of the human respiratory tract using a suspension of lipids and proteins containing bound-calcium and/or magnesium ions
DE69904051T2 (de) Zubereitung enthaltend derivate von phenylaminothiophenessigsäure zur behandlung der akuten respiratorischen insuffizienz (ards) und der akuten respiratorischen insuffizienz bei kindern (irds)
JP3118869B2 (ja) プロスタグランジン類含有脂肪小体組成物
JPS58222022A (ja) 合成肺表面活性剤及びそれを有効成分とする呼吸窮迫症候群治療剤
WO2007097502A1 (en) Composition for reducing the exudation of serum proteins
EP0510197A1 (en) Fat emulsion
WO2002034270A1 (en) Treatment of respiratory distress syndrome with powder surfactant composition
KR20190039933A (ko) 재구성된 폐 계면활성제 조성물을 포함하는 안정한 약제학적 제제

Legal Events

Date Code Title Description
MKEX Expiry