CA1182753A - Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells - Google Patents
Anaerobic method for preserving whole blood, tissue and components containing living mammalian cellsInfo
- Publication number
- CA1182753A CA1182753A CA000409277A CA409277A CA1182753A CA 1182753 A CA1182753 A CA 1182753A CA 000409277 A CA000409277 A CA 000409277A CA 409277 A CA409277 A CA 409277A CA 1182753 A CA1182753 A CA 1182753A
- Authority
- CA
- Canada
- Prior art keywords
- starch
- whole blood
- biological substance
- article
- mammalian
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 title claims abstract description 101
- 210000004369 blood Anatomy 0.000 title claims abstract description 100
- 238000000034 method Methods 0.000 title claims abstract description 55
- 210000004962 mammalian cell Anatomy 0.000 title claims abstract description 5
- 235000019426 modified starch Nutrition 0.000 claims abstract description 50
- 229920000881 Modified starch Polymers 0.000 claims abstract description 46
- 229940050526 hydroxyethylstarch Drugs 0.000 claims abstract description 42
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims abstract description 41
- 239000000126 substance Substances 0.000 claims abstract description 40
- 239000000203 mixture Substances 0.000 claims abstract description 30
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 13
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 9
- 229940127219 anticoagulant drug Drugs 0.000 claims abstract description 9
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims abstract description 8
- 239000001341 hydroxy propyl starch Substances 0.000 claims abstract description 8
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims abstract description 8
- 210000004027 cell Anatomy 0.000 claims description 27
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 18
- 238000003860 storage Methods 0.000 claims description 18
- 210000003743 erythrocyte Anatomy 0.000 claims description 16
- DNZMDASEFMLYBU-RNBXVSKKSA-N hydroxyethyl starch Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]1O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]1OCCO DNZMDASEFMLYBU-RNBXVSKKSA-N 0.000 claims description 16
- 239000007789 gas Substances 0.000 claims description 11
- 238000010926 purge Methods 0.000 claims description 9
- 210000000265 leukocyte Anatomy 0.000 claims description 8
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 5
- 108060003951 Immunoglobulin Proteins 0.000 claims description 4
- 102000018358 immunoglobulin Human genes 0.000 claims description 4
- 238000009877 rendering Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 16
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 claims 4
- 229910001873 dinitrogen Inorganic materials 0.000 claims 4
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical class S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 19
- 239000008103 glucose Substances 0.000 abstract description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 4
- 238000001914 filtration Methods 0.000 abstract description 4
- 230000001413 cellular effect Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 19
- 229920002472 Starch Polymers 0.000 description 13
- 239000008107 starch Substances 0.000 description 13
- 235000019698 starch Nutrition 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 11
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 238000004321 preservation Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- 230000008961 swelling Effects 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 210000001772 blood platelet Anatomy 0.000 description 6
- 238000007710 freezing Methods 0.000 description 6
- 230000008014 freezing Effects 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 229920002307 Dextran Polymers 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 230000000959 cryoprotective effect Effects 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 238000005138 cryopreservation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000005057 refrigeration Methods 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- VEMLQICWTSVKQH-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;propane-1,2,3-triol Chemical compound OCC(O)CO.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VEMLQICWTSVKQH-BTVCFUMJSA-N 0.000 description 2
- IJRKANNOPXMZSG-SSPAHAAFSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IJRKANNOPXMZSG-SSPAHAAFSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 239000004606 Fillers/Extenders Substances 0.000 description 2
- -1 PVP Chemical compound 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000002577 cryoprotective agent Substances 0.000 description 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- BHMLFPOTZYRDKA-IRXDYDNUSA-N (2s)-2-[(s)-(2-iodophenoxy)-phenylmethyl]morpholine Chemical compound IC1=CC=CC=C1O[C@@H](C=1C=CC=CC=1)[C@H]1OCCNC1 BHMLFPOTZYRDKA-IRXDYDNUSA-N 0.000 description 1
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 102100027522 Baculoviral IAP repeat-containing protein 7 Human genes 0.000 description 1
- 101710177963 Baculoviral IAP repeat-containing protein 7 Proteins 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000896693 Disa Species 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 241001527806 Iti Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 108010047620 Phytohemagglutinins Proteins 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 101100421299 Schizosaccharomyces pombe (strain 972 / ATCC 24843) set7 gene Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 229940045971 anti bac Drugs 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000003914 blood derivative Substances 0.000 description 1
- 238000004555 blood preservation Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 208000037516 chromosome inversion disease Diseases 0.000 description 1
- 239000000701 coagulant Substances 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000002338 cryopreservative effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000002542 deteriorative effect Effects 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- 229940120503 dihydroxyacetone Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 101150114489 dop gene Proteins 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 229910052743 krypton Inorganic materials 0.000 description 1
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 230000001885 phytohemagglutinin Effects 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 231100000683 possible toxicity Toxicity 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24413781A | 1981-03-16 | 1981-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1182753A true CA1182753A (en) | 1985-02-19 |
Family
ID=22921506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000409277A Expired CA1182753A (en) | 1981-03-16 | 1982-08-12 | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0061277B1 (https=) |
| JP (1) | JPS5933224A (https=) |
| AU (1) | AU559805B2 (https=) |
| CA (1) | CA1182753A (https=) |
| DE (1) | DE3272969D1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| GB9021325D0 (en) * | 1990-10-01 | 1990-11-14 | Geistlich Soehne Ag | Chemical composition |
| AUPQ906300A0 (en) * | 2000-07-28 | 2000-08-24 | Monash University | Method of preserving cells and uses thereof |
| CN1901795B (zh) | 2003-10-22 | 2014-03-26 | 弗雷德哈钦森癌症研究中心 | 用于在细胞，组织，器官，和有机体中诱导停滞的方法，组合物和装置 |
| CA2605631A1 (en) | 2005-04-20 | 2006-10-26 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
| WO2014051141A1 (ja) * | 2012-09-28 | 2014-04-03 | 積水メディカル株式会社 | 無希釈系イムノクロマトグラフ法試薬において希釈試料を測定するための添加物 |
| KR102101684B1 (ko) * | 2012-11-30 | 2020-04-17 | 리치 테크놀로지스 홀딩 컴퍼니 엘엘씨 | 적혈구 보존 방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523938A (en) * | 1967-12-13 | 1970-08-11 | American Hospital Supply Corp | Starch plasma expanders and process of preparation |
| US3937821A (en) * | 1971-08-21 | 1976-02-10 | Kyorin Seiyaku Kabushiki Kaisha | Plasma substitute including artificial starch and method for the preparation thereof |
| US3912715A (en) * | 1972-03-31 | 1975-10-14 | Nat Starch Chem Corp | Process for preparing novel cationic flocculating agents and paper made there-with |
| GB1514720A (en) * | 1974-10-07 | 1978-06-21 | Secr Defence | Preparation of hydroxyethyl starch |
| US4004975A (en) * | 1975-12-30 | 1977-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method of isolating and cryopreserving human white cells from whole blood |
| DE2634539C2 (de) * | 1976-07-31 | 1983-08-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von saugfähigen, modifizierten Stärkeethern und deren Verwendung |
| US4153585A (en) * | 1978-05-08 | 1979-05-08 | National Starch And Chemical Corporation | Starch ether derivatives and process for the preparation thereof |
| DE2908436A1 (de) * | 1979-03-05 | 1980-09-25 | Fresenius Chem Pharm Ind | Kolloidales gefrierschutzmittel |
-
1982
- 1982-03-15 EP EP82301307A patent/EP0061277B1/en not_active Expired
- 1982-03-15 DE DE8282301307T patent/DE3272969D1/de not_active Expired
- 1982-08-12 CA CA000409277A patent/CA1182753A/en not_active Expired
- 1982-08-13 AU AU87173/82A patent/AU559805B2/en not_active Ceased
- 1982-08-14 JP JP57141598A patent/JPS5933224A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0061277B1 (en) | 1986-09-03 |
| JPH0557244B2 (https=) | 1993-08-23 |
| AU8717382A (en) | 1984-02-16 |
| EP0061277A2 (en) | 1982-09-29 |
| DE3272969D1 (en) | 1986-10-09 |
| JPS5933224A (ja) | 1984-02-23 |
| AU559805B2 (en) | 1987-03-19 |
| EP0061277A3 (en) | 1983-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4473552A (en) | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells | |
| US5789151A (en) | Prolonged cold storage of red blood cells by oxygen removal and additive usage | |
| Stiff et al. | Unfractionated human marrow cell cryopreservation using dimethylsulfoxide and hydroxyethyl starch | |
| KR100395033B1 (ko) | 산소제거를 사용하여 냉장된 적혈구의 유효저장수명을 연장시키는 방법 | |
| EP0142339B1 (en) | Method of and medium for storing blood platelets | |
| Hubel | Parameters of cell freezing: implications for the cryopreservation of stem cells | |
| KR920005684B1 (ko) | 혈장을 함유하지 않는 수혈가능한 혈소판 저장 합성매질 | |
| US7358039B2 (en) | Fixed-dried red blood cells | |
| KR0148223B1 (ko) | 적혈구세포 냉동방법 | |
| WO1996029862A1 (en) | Cryopreservation of cell suspensions | |
| WO1996021351A2 (en) | Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials | |
| AU2009228141A1 (en) | Mehtod, system, and apparatus for hypothermic collection, storage, transport and banking of birth tissue | |
| Sputtek | Cryopreservation of red blood cells and platelets | |
| CA1182753A (en) | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells | |
| Johnson et al. | A deep eutectic solvent is an effective cryoprotective agent for platelets | |
| EP0647267B1 (en) | Stem cell storage | |
| AU6427699A (en) | Compositions and methods for preserving platelets | |
| Owens et al. | Cryopreserved platelets have decreased adhesive capacity | |
| Niinistö et al. | Storage of equine red blood cells as a concentrate | |
| Hardeman et al. | Storage of Human Blood Platelets | |
| Fleming et al. | Cryopreservation of hematopoietic stem cells: emerging science, technology and issues | |
| Denysova et al. | Cryopreservation of canine erythrocytes using dimethyl sulfoxide, polyethylene glycol and sucrose | |
| Rathbun et al. | Posttransfusion survival of red cells frozen for 8 weeks after 42‐day liquid storage in AS‐3 | |
| NZ201599A (en) | Preserving biological substances containing mammalian cells | |
| IE53734B1 (en) | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEC | Expiry (correction) | ||
| MKEX | Expiry |