CA1174672A - Process for the preparation of new vinblastine cytostatic compounds - Google Patents

Process for the preparation of new vinblastine cytostatic compounds

Info

Publication number
CA1174672A
CA1174672A CA000383978A CA383978A CA1174672A CA 1174672 A CA1174672 A CA 1174672A CA 000383978 A CA000383978 A CA 000383978A CA 383978 A CA383978 A CA 383978A CA 1174672 A CA1174672 A CA 1174672A
Authority
CA
Canada
Prior art keywords
vinblastine
general formula
compounds
ethyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000383978A
Other languages
English (en)
French (fr)
Inventor
Tibor Keve
Gyorgy Fekete
Lajos Dancsi
Sandor Kerpel-Fronius
Janos Sugar
Zsuzsanna Relle
Eszter Dezseri
Sandor Gorog
Csaba Szantay
Tibor Acs
Lajos Szabo
Katalin Honty
Sandor Eckhardt
Ivan Hindi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Application granted granted Critical
Publication of CA1174672A publication Critical patent/CA1174672A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA000383978A 1980-10-22 1981-08-17 Process for the preparation of new vinblastine cytostatic compounds Expired CA1174672A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU802562A HU181745B (en) 1980-10-22 1980-10-22 Process for producing new vinblastin and leurosidin derivatives
HU2562/80 1980-10-22

Publications (1)

Publication Number Publication Date
CA1174672A true CA1174672A (en) 1984-09-18

Family

ID=10960005

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000383978A Expired CA1174672A (en) 1980-10-22 1981-08-17 Process for the preparation of new vinblastine cytostatic compounds

Country Status (15)

Country Link
JP (1) JPS5772992A (en)van)
AT (1) AT376678B (en)van)
BE (1) BE889989A (en)van)
CA (1) CA1174672A (en)van)
CH (1) CH648320A5 (en)van)
DE (1) DE3132476A1 (en)van)
ES (1) ES505310A0 (en)van)
FR (1) FR2492384B1 (en)van)
GB (1) GB2086378B (en)van)
HU (1) HU181745B (en)van)
IL (1) IL63593A0 (en)van)
IT (1) IT1138154B (en)van)
NL (1) NL8103844A (en)van)
SE (1) SE442116B (en)van)
SU (1) SU1053757A3 (en)van)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193318B (en) * 1985-06-12 1987-09-28 Richter Gedeon Vegyeszet Process for producing new bis- indol derivatives
HU198074B (en) * 1985-06-12 1989-07-28 Richter Gedeon Vegyeszet Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds
JPH0321210U (en)van) * 1989-07-11 1991-03-01

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899493A (en) * 1972-12-29 1975-08-12 Richter Gedeon Vegyeszet Chromic acid oxidation of vinblastine sulfate to form vincristine
HU178706B (en) * 1979-04-23 1982-06-28 Richter Gedeon Vegyeszet Process for preparing bis-indole alkaloids and acid addition salts thereof
JPS56128643A (en) * 1980-03-13 1981-10-08 Sintokogio Ltd Vertical flaskless type molding machine

Also Published As

Publication number Publication date
SU1053757A3 (ru) 1983-11-07
IT1138154B (it) 1986-09-17
ES8300777A1 (es) 1982-12-01
SE8104877L (sv) 1982-04-23
ATA358681A (de) 1984-05-15
DE3132476A1 (de) 1982-06-09
GB2086378A (en) 1982-05-12
BE889989A (fr) 1982-02-17
CH648320A5 (de) 1985-03-15
FR2492384B1 (fr) 1986-04-04
DE3132476C2 (en)van) 1991-04-18
JPH0161118B2 (en)van) 1989-12-27
IT8123540A0 (it) 1981-08-17
SE442116B (sv) 1985-12-02
AT376678B (de) 1984-12-27
HU181745B (en) 1983-11-28
JPS5772992A (en) 1982-05-07
ES505310A0 (es) 1982-12-01
NL8103844A (nl) 1982-05-17
FR2492384A1 (fr) 1982-04-23
GB2086378B (en) 1984-07-25
IL63593A0 (en) 1981-11-30

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Legal Events

Date Code Title Description
MKEX Expiry