CA1131626A - 5-SUBSTITUTED 1(2'-DEOXY-2'-SUBSTITUTED- .beta.-D-ARABINOFURANOSYL)PYRIMIDINE NUCLEOSIDES - Google Patents

5-SUBSTITUTED 1(2'-DEOXY-2'-SUBSTITUTED- .beta.-D-ARABINOFURANOSYL)PYRIMIDINE NUCLEOSIDES

Info

Publication number
CA1131626A
CA1131626A CA336,359A CA336359A CA1131626A CA 1131626 A CA1131626 A CA 1131626A CA 336359 A CA336359 A CA 336359A CA 1131626 A CA1131626 A CA 1131626A
Authority
CA
Canada
Prior art keywords
deoxy
beta
arabinofuranosyl
acetyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA336,359A
Other languages
English (en)
French (fr)
Inventor
Carlos Lopez
Kyoichi A. Watanabe
Uri Reichman
Jack J. Fox
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Application granted granted Critical
Publication of CA1131626A publication Critical patent/CA1131626A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA336,359A 1978-10-02 1979-09-26 5-SUBSTITUTED 1(2'-DEOXY-2'-SUBSTITUTED- .beta.-D-ARABINOFURANOSYL)PYRIMIDINE NUCLEOSIDES Expired CA1131626A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/948,189 US4211773A (en) 1978-10-02 1978-10-02 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
US948,189 1978-10-02

Publications (1)

Publication Number Publication Date
CA1131626A true CA1131626A (en) 1982-09-14

Family

ID=25487441

Family Applications (1)

Application Number Title Priority Date Filing Date
CA336,359A Expired CA1131626A (en) 1978-10-02 1979-09-26 5-SUBSTITUTED 1(2'-DEOXY-2'-SUBSTITUTED- .beta.-D-ARABINOFURANOSYL)PYRIMIDINE NUCLEOSIDES

Country Status (8)

Country Link
US (1) US4211773A (enExample)
EP (1) EP0010205B1 (enExample)
JP (1) JPS5549395A (enExample)
AU (1) AU533135B2 (enExample)
CA (1) CA1131626A (enExample)
DE (1) DE2965318D1 (enExample)
ES (1) ES484626A1 (enExample)
HU (1) HU182597B (enExample)

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US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5594124A (en) * 1992-06-22 1997-01-14 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5426183A (en) * 1992-06-22 1995-06-20 Eli Lilly And Company Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5401838A (en) * 1992-06-22 1995-03-28 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
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US5811073A (en) * 1995-06-19 1998-09-22 President And Fellows Of Harvard College Method for radioisotopic detection and localization of inflammation in a host
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Also Published As

Publication number Publication date
EP0010205B1 (en) 1983-05-04
AU5075779A (en) 1980-04-17
JPS6254315B2 (enExample) 1987-11-13
JPS5549395A (en) 1980-04-09
ES484626A1 (es) 1980-05-16
US4211773A (en) 1980-07-08
DE2965318D1 (en) 1983-06-09
HU182597B (en) 1984-02-28
EP0010205A1 (en) 1980-04-30
AU533135B2 (en) 1983-11-03

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