CA1105024A - 2-(thio substitue) imidazoles 4,5-dicycliques, anti- inflammatoires et leurs sulfoxydes et sulfones correspondants - Google Patents

2-(thio substitue) imidazoles 4,5-dicycliques, anti- inflammatoires et leurs sulfoxydes et sulfones correspondants

Info

Publication number
CA1105024A
CA1105024A CA296,606A CA296606A CA1105024A CA 1105024 A CA1105024 A CA 1105024A CA 296606 A CA296606 A CA 296606A CA 1105024 A CA1105024 A CA 1105024A
Authority
CA
Canada
Prior art keywords
thienyl
compound
prepared
pyridyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA296,606A
Other languages
English (en)
Inventor
Saul C. Cherkofsky
Thomas R. Sharpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/865,832 external-priority patent/US4159338A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Application granted granted Critical
Publication of CA1105024A publication Critical patent/CA1105024A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA296,606A 1977-02-09 1978-02-07 2-(thio substitue) imidazoles 4,5-dicycliques, anti- inflammatoires et leurs sulfoxydes et sulfones correspondants Expired CA1105024A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76722077A 1977-02-09 1977-02-09
US767,220 1977-02-09
US865,832 1978-01-05
US05/865,832 US4159338A (en) 1977-02-09 1978-01-05 Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones

Publications (1)

Publication Number Publication Date
CA1105024A true CA1105024A (fr) 1981-07-14

Family

ID=27117879

Family Applications (1)

Application Number Title Priority Date Filing Date
CA296,606A Expired CA1105024A (fr) 1977-02-09 1978-02-07 2-(thio substitue) imidazoles 4,5-dicycliques, anti- inflammatoires et leurs sulfoxydes et sulfones correspondants

Country Status (26)

Country Link
JP (1) JPS53130664A (fr)
AR (1) AR219310A1 (fr)
AT (1) AT361470B (fr)
AU (1) AU517028B2 (fr)
CA (1) CA1105024A (fr)
CH (1) CH644108A5 (fr)
DE (1) DE2805167A1 (fr)
DK (1) DK16778A (fr)
ES (1) ES466794A1 (fr)
FI (1) FI69462C (fr)
FR (1) FR2380275A1 (fr)
GB (1) GB1564184A (fr)
GR (1) GR64142B (fr)
HU (1) HU178211B (fr)
IE (1) IE46187B1 (fr)
IL (1) IL53995A (fr)
IT (1) IT1092588B (fr)
LU (1) LU79024A1 (fr)
MX (1) MX5933E (fr)
NL (1) NL7801453A (fr)
NO (1) NO148265C (fr)
NZ (1) NZ186410A (fr)
PH (1) PH13852A (fr)
PT (1) PT67626B (fr)
SE (1) SE7801467L (fr)
YU (1) YU28878A (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004648B1 (fr) * 1978-04-11 1982-08-25 Ciba-Geigy Ag Dérivés de mercapto-imidazole, procédé pour leur préparation, dérivés de mercapto-imidazole pour le traitement de maladies inflammatoires et leurs compositions pharmaceutiques
US4199592A (en) * 1978-08-29 1980-04-22 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DK337779A (da) * 1978-10-02 1980-04-03 Du Pont Fremgangsmaade til fremstilling af antiinflammatoriske 2-substituerede 1h-phenantro (9,10)-imidazoler
AT374198B (de) * 1979-04-10 1984-03-26 Ciba Geigy Ag Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate, ihrer n-oxyde und ihrer salze
FI850995L (fi) * 1984-03-16 1985-09-17 Ciba Geigy Ag Foerfarande foer framstaellning av nya 3-merkapto-1,2,4-triazacykloalkadienderivat.
AU8757098A (en) * 1997-06-30 1999-02-10 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (fr) * 1972-07-29 1978-11-24
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler

Also Published As

Publication number Publication date
DK16778A (da) 1978-08-10
IE46187B1 (en) 1983-03-23
GR64142B (en) 1980-01-28
ATA86978A (de) 1980-08-15
FI69462C (fi) 1986-02-10
FI780428A (fi) 1978-08-10
NO148265C (no) 1983-09-07
IL53995A0 (en) 1978-04-30
CH644108A5 (en) 1984-07-13
GB1564184A (en) 1980-04-02
IL53995A (en) 1982-02-28
AU517028B2 (en) 1981-07-02
IT1092588B (it) 1985-07-12
ES466794A1 (es) 1979-08-01
FR2380275A1 (fr) 1978-09-08
AR219310A1 (es) 1980-08-15
AU3309678A (en) 1979-08-16
HU178211B (en) 1982-03-28
PT67626B (en) 1979-07-17
MX5933E (es) 1984-08-30
YU28878A (en) 1983-01-21
AT361470B (de) 1981-03-10
NZ186410A (en) 1979-12-11
FR2380275B1 (fr) 1982-01-08
NL7801453A (nl) 1978-08-11
IE780279L (en) 1978-08-09
SE7801467L (sv) 1978-08-10
NO780433L (no) 1978-08-10
JPS53130664A (en) 1978-11-14
LU79024A1 (fr) 1979-05-25
DE2805167A1 (de) 1978-08-10
FI69462B (fi) 1985-10-31
PT67626A (en) 1978-03-01
NO148265B (no) 1983-05-30
PH13852A (en) 1980-10-22
IT7820078A0 (it) 1978-02-07

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Legal Events

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