CA1104127A - Method for preparing pyrogen free collagen - Google Patents
Method for preparing pyrogen free collagenInfo
- Publication number
- CA1104127A CA1104127A CA307,883A CA307883A CA1104127A CA 1104127 A CA1104127 A CA 1104127A CA 307883 A CA307883 A CA 307883A CA 1104127 A CA1104127 A CA 1104127A
- Authority
- CA
- Canada
- Prior art keywords
- corium
- collagen
- aqueous
- hypochlorite
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002510 pyrogen Substances 0.000 title claims abstract description 27
- 102000008186 Collagen Human genes 0.000 title claims abstract description 23
- 108010035532 Collagen Proteins 0.000 title claims abstract description 23
- 229920001436 collagen Polymers 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000005406 washing Methods 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims abstract description 5
- -1 alkaline earth metal hypochlorites Chemical class 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 23
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 22
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 19
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 229960005076 sodium hypochlorite Drugs 0.000 claims 8
- 238000012545 processing Methods 0.000 abstract description 4
- 239000003513 alkali Substances 0.000 abstract description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 22
- 229960005188 collagen Drugs 0.000 description 14
- 239000012153 distilled water Substances 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000011046 pyrogen test Methods 0.000 description 3
- 230000001698 pyrogenic effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229940127554 medical product Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000007790 scraping Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000490025 Schefflera digitata Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000003372 endocrine gland Anatomy 0.000 description 1
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 235000015250 liver sausages Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H1/00—Pretreatment of collagen-containing raw materials for the manufacture of glue
- C09H1/04—Pretreatment of collagen-containing raw materials for the manufacture of glue of hides, hoofs, or leather scrap
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Treatment And Processing Of Natural Fur Or Leather (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82835077A | 1977-08-29 | 1977-08-29 | |
| US828,350 | 1977-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1104127A true CA1104127A (en) | 1981-06-30 |
Family
ID=25251559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA307,883A Expired CA1104127A (en) | 1977-08-29 | 1978-07-21 | Method for preparing pyrogen free collagen |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5449301A (enrdf_load_stackoverflow) |
| CA (1) | CA1104127A (enrdf_load_stackoverflow) |
| DE (1) | DE2835220A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2401973A1 (enrdf_load_stackoverflow) |
| GB (1) | GB2003158B (enrdf_load_stackoverflow) |
| IT (1) | IT1106868B (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4221491C2 (de) * | 1992-06-29 | 1994-09-29 | Pohl Boskamp Gmbh Chem Pharma | Verfahren zur Herstellung von Weichgelatinekapseln |
| US7083820B2 (en) * | 2000-09-29 | 2006-08-01 | Schilling Marvin L | Method for producing biologically active products |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR51337E (fr) * | 1941-01-04 | 1942-04-15 | Procédé pour la fabrication de substances protéides ayant une valeur marchande, en particulier la colle et la gélatine, en partant de déchets de cuirs | |
| CH441621A (de) * | 1963-06-04 | 1967-08-15 | Bayer Ag | Verfahren zur Herstellung von als Blutersatzflüssigkeit verwendbaren Gelatinepräparaten |
| US3634561A (en) * | 1968-03-18 | 1972-01-11 | Lever Brothers Ltd | Collagen products |
| US3742955A (en) * | 1970-09-29 | 1973-07-03 | Fmc Corp | Fibrous collagen derived product having hemostatic and wound binding properties |
| US4035483A (en) * | 1973-05-29 | 1977-07-12 | John Bunyan | Antiseptic and non-toxic substance and a method of making the same |
-
1978
- 1978-07-21 CA CA307,883A patent/CA1104127A/en not_active Expired
- 1978-08-07 GB GB7832436A patent/GB2003158B/en not_active Expired
- 1978-08-08 IT IT50660/78A patent/IT1106868B/it active
- 1978-08-11 DE DE19782835220 patent/DE2835220A1/de active Granted
- 1978-08-25 FR FR7824752A patent/FR2401973A1/fr active Granted
- 1978-08-29 JP JP10544878A patent/JPS5449301A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB2003158A (en) | 1979-03-07 |
| JPS6351184B2 (enrdf_load_stackoverflow) | 1988-10-13 |
| DE2835220C2 (enrdf_load_stackoverflow) | 1988-06-30 |
| FR2401973B1 (enrdf_load_stackoverflow) | 1982-07-23 |
| IT1106868B (it) | 1985-11-18 |
| FR2401973A1 (fr) | 1979-03-30 |
| DE2835220A1 (de) | 1979-03-08 |
| GB2003158B (en) | 1982-03-24 |
| IT7850660A0 (it) | 1978-08-08 |
| JPS5449301A (en) | 1979-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |