CA1084300A - Instrument for determining the contents of metabolic products in the blood - Google Patents
Instrument for determining the contents of metabolic products in the bloodInfo
- Publication number
- CA1084300A CA1084300A CA272,129A CA272129A CA1084300A CA 1084300 A CA1084300 A CA 1084300A CA 272129 A CA272129 A CA 272129A CA 1084300 A CA1084300 A CA 1084300A
- Authority
- CA
- Canada
- Prior art keywords
- blood
- instrument
- laser
- metabolic products
- atr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 title claims abstract description 33
- 210000004369 blood Anatomy 0.000 title claims abstract description 33
- 230000002503 metabolic effect Effects 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 13
- 230000005855 radiation Effects 0.000 claims description 10
- 238000001514 detection method Methods 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 24
- 238000005259 measurement Methods 0.000 description 18
- 238000010521 absorption reaction Methods 0.000 description 17
- 238000005102 attenuated total reflection Methods 0.000 description 17
- 238000012360 testing method Methods 0.000 description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 235000019441 ethanol Nutrition 0.000 description 8
- 239000000243 solution Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 229910052732 germanium Inorganic materials 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 241000448280 Elates Species 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 229910003327 LiNbO3 Inorganic materials 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005672 electromagnetic field Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000010842 industrial wastewater Substances 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000010905 molecular spectroscopy Methods 0.000 description 1
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- PGAPATLGJSQQBU-UHFFFAOYSA-M thallium(i) bromide Chemical compound [Tl]Br PGAPATLGJSQQBU-UHFFFAOYSA-M 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
- Y10T436/144444—Glucose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/203332—Hydroxyl containing
- Y10T436/204165—Ethanol
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP2606991.0 | 1976-02-20 | ||
DE19762606991 DE2606991A1 (de) | 1976-02-20 | 1976-02-20 | Geraet zur bestimmung des gehaltes von stoffwechselprodukten im blut |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1084300A true CA1084300A (en) | 1980-08-26 |
Family
ID=5970482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA272,129A Expired CA1084300A (en) | 1976-02-20 | 1977-02-18 | Instrument for determining the contents of metabolic products in the blood |
Country Status (12)
Country | Link |
---|---|
US (1) | US4169676A (en:Method) |
JP (1) | JPS52102094A (en:Method) |
BE (1) | BE851606A (en:Method) |
CA (1) | CA1084300A (en:Method) |
CH (1) | CH612271A5 (en:Method) |
DE (1) | DE2606991A1 (en:Method) |
FR (1) | FR2341866A1 (en:Method) |
GB (1) | GB1531375A (en:Method) |
IT (1) | IT1071579B (en:Method) |
LU (1) | LU76810A1 (en:Method) |
NL (1) | NL7701778A (en:Method) |
SE (1) | SE7701901L (en:Method) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS202434B1 (en) * | 1979-01-09 | 1981-01-30 | Ivan Dolejsi | Method of detec ing the malign ulcers from the the urine samples |
DE2934190A1 (de) * | 1979-08-23 | 1981-03-19 | Müller, Gerhard, Prof. Dr.-Ing., 7080 Aalen | Verfahren und vorrichtung zur molekuelspektroskopie, insbesondere zur bestimmung von stoffwechselprodukten |
US4527062A (en) * | 1983-07-05 | 1985-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Portable infrared spectrophotometer |
DE3344019C2 (de) * | 1983-12-06 | 1995-05-04 | Max Planck Gesellschaft | Vorrichtung zur optischen Messung der Konzentration einer in einer Probe enthaltenen Komponente |
DE3477991D1 (en) * | 1984-05-04 | 1989-06-08 | Kurashiki Boseki Kk | Spectrophotometric apparatus for the non-invasive determination of glucose in body tissues |
DE3481644D1 (de) * | 1984-12-10 | 1990-04-19 | Prutec Ltd | Verfahren zum optischen nachweis von parametern von substanzen in einem fluessigen analyt. |
DE3480490D1 (en) * | 1984-12-10 | 1989-12-21 | Prutec Ltd | Optical test probe and apparatus for optically determining species in solution |
EP0221005A3 (de) * | 1985-09-07 | 1987-12-02 | Wagner, Wolfgang, Dr.med. | Injektionsvorrichtung mit Sensor |
US4704029A (en) * | 1985-12-26 | 1987-11-03 | Research Corporation | Blood glucose monitor |
US4962021A (en) * | 1986-06-20 | 1990-10-09 | Personal Diagnostics, Inc. | Analyte determination using gel including a reagent system reacts with analyte to change transmissive property of gel detectable by light beam transmitted through gel by total internal reflectance |
US4901728A (en) * | 1988-05-31 | 1990-02-20 | Eol, Inc. | Personal glucose monitor |
GB8818690D0 (en) * | 1988-08-05 | 1988-09-07 | Red Kite Technology Ltd | Refractive index measurement |
US5137023A (en) * | 1990-04-19 | 1992-08-11 | Worcester Polytechnic Institute | Method and apparatus for monitoring blood analytes noninvasively by pulsatile photoplethysmography |
ATE80225T1 (de) * | 1989-05-23 | 1992-09-15 | Biosensors Technology Inc | Verfahren zur bestimmung mittels strahlungsabsorption von substanzen in absorbierenden und streuenden matrixmaterialien. |
US5112124A (en) * | 1990-04-19 | 1992-05-12 | Worcester Polytechnic Institute | Method and apparatus for measuring the concentration of absorbing substances |
US5183042A (en) * | 1989-05-23 | 1993-02-02 | Vivascan Corporation | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
US5178142A (en) * | 1989-05-23 | 1993-01-12 | Vivascan Corporation | Electromagnetic method and apparatus to measure constituents of human or animal tissue |
CA2028261C (en) * | 1989-10-28 | 1995-01-17 | Won Suck Yang | Non-invasive method and apparatus for measuring blood glucose concentration |
US5222496A (en) * | 1990-02-02 | 1993-06-29 | Angiomedics Ii, Inc. | Infrared glucose sensor |
US5239180A (en) * | 1990-02-02 | 1993-08-24 | Boston Advnaced Technologies, Inc. | Laser systems for food analysis based on reflectance ratio detection |
US5222495A (en) * | 1990-02-02 | 1993-06-29 | Angiomedics Ii, Inc. | Non-invasive blood analysis by near infrared absorption measurements using two closely spaced wavelengths |
US5246004A (en) * | 1990-02-02 | 1993-09-21 | Angiomedics Ii, Inc. | Infrared cholesterol sensor |
US5168325A (en) * | 1990-02-28 | 1992-12-01 | Board Of Control Of Michigan Technological University | Interferometric measurement of glucose by refractive index determination |
US5079421A (en) * | 1990-04-19 | 1992-01-07 | Inomet, Inc. | Invasive FTIR blood constituent testing |
US5115133A (en) * | 1990-04-19 | 1992-05-19 | Inomet, Inc. | Testing of body fluid constituents through measuring light reflected from tympanic membrane |
US5209231A (en) * | 1990-11-02 | 1993-05-11 | University Of Connecticut | Optical glucose sensor apparatus and method |
DK181191D0 (da) * | 1991-11-04 | 1991-11-04 | Novo Nordisk As | Apparat |
US5277181A (en) * | 1991-12-12 | 1994-01-11 | Vivascan Corporation | Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis |
WO1993012712A1 (en) * | 1991-12-31 | 1993-07-08 | Vivascan Corporation | Blood constituent determination based on differential spectral analysis |
US5452716A (en) * | 1992-02-25 | 1995-09-26 | Novo Nordisk A/S | Method and device for in vivo measuring the concentration of a substance in the blood |
DK39792D0 (da) * | 1992-03-25 | 1992-03-25 | Foss Electric As | Fremgangsmaade til bestemmelse af en komponent |
DE4227813A1 (de) * | 1992-08-21 | 1994-02-24 | Kim Yoon Ok | Vorrichtung zur qualitativen und/oder quantitativen Bestimmung einer zu analysierenden Probe |
US5379764A (en) * | 1992-12-09 | 1995-01-10 | Diasense, Inc. | Non-invasive determination of analyte concentration in body of mammals |
DE4243142A1 (de) * | 1992-12-19 | 1994-06-23 | Boehringer Mannheim Gmbh | Vorrichtung zur in-vivo-Bestimmung einer optischen Eigenschaft des Kammerwassers des Auges |
US5615672A (en) * | 1993-01-28 | 1997-04-01 | Optiscan, Inc. | Self-emission noninvasive infrared spectrophotometer with body temperature compensation |
US5344133A (en) * | 1993-02-25 | 1994-09-06 | Eastman Kodak Company | Vacuum belt feeder having a positive air pressure separator and method of using a vacuum belt feeder |
SE501668C2 (sv) * | 1993-08-06 | 1995-04-10 | Biolin Medical Ab | Kvantifiering av CD-transferrin vid hög alkoholkonsumtion med HPLC |
US5533509A (en) * | 1993-08-12 | 1996-07-09 | Kurashiki Boseki Kabushiki Kaisha | Method and apparatus for non-invasive measurement of blood sugar level |
JP2807777B2 (ja) * | 1994-09-09 | 1998-10-08 | 工業技術院長 | スラブ光導波路を利用した光吸収スペクトル測定装置 |
JP2802361B2 (ja) * | 1994-10-07 | 1998-09-24 | 工業技術院長 | スラブ光導波路を利用した露点測定装置 |
DE69525226T2 (de) * | 1994-11-25 | 2002-06-27 | Kyoto Daiichi Kagaku Co. Ltd., Kyoto | Vorrichtung und Verfahren zur Bestimmung von Wasserstoffperoxid |
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Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3308709A (en) * | 1963-06-12 | 1967-03-14 | Philips Corp | Multiple reflection optical device |
US3313290A (en) * | 1963-08-14 | 1967-04-11 | Research Corp | Spectrofluorometer |
FR1474447A (fr) * | 1965-04-01 | 1967-03-24 | Philips Nv | élément optique, notamment pour spectroscopie par réflexion interne |
DE1917588A1 (de) * | 1969-04-05 | 1970-10-15 | Kyffhaeuserhuette Veb Maschf | Verfahren und Vorrichtung zur kontinuierlichen Messung des Milchfettgehaltes in Milch |
CH501923A (de) * | 1969-07-02 | 1971-01-15 | Antenen Karl Dipl Phys Dr | Verfahren zur spektroskopischen Untersuchung von Material eines Tier- oder Menschenkörpers |
DE2164670A1 (de) * | 1971-12-24 | 1973-06-28 | Bbc Brown Boveri & Cie | Verfahren zur kontinuierlichen messung organischer substanzen in wasser und anordnung zur durchfuehrung des verfahrens |
US3902807A (en) * | 1973-10-25 | 1975-09-02 | Du Pont | Method for operating an attenuated total reflection infrared system |
-
1976
- 1976-02-20 DE DE19762606991 patent/DE2606991A1/de not_active Ceased
-
1977
- 1977-01-25 JP JP647777A patent/JPS52102094A/ja active Pending
- 1977-02-17 US US05/769,777 patent/US4169676A/en not_active Expired - Lifetime
- 1977-02-18 CH CH203377A patent/CH612271A5/xx not_active IP Right Cessation
- 1977-02-18 BE BE175080A patent/BE851606A/xx unknown
- 1977-02-18 IT IT67375/77A patent/IT1071579B/it active
- 1977-02-18 NL NL7701778A patent/NL7701778A/xx not_active Application Discontinuation
- 1977-02-18 LU LU76810A patent/LU76810A1/xx unknown
- 1977-02-18 GB GB6861/77A patent/GB1531375A/en not_active Expired
- 1977-02-18 CA CA272,129A patent/CA1084300A/en not_active Expired
- 1977-02-18 FR FR7704735A patent/FR2341866A1/fr not_active Withdrawn
- 1977-02-21 SE SE7701901A patent/SE7701901L/ not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
GB1531375A (en) | 1978-11-08 |
IT1071579B (it) | 1985-04-10 |
US4169676A (en) | 1979-10-02 |
NL7701778A (nl) | 1977-08-23 |
DE2606991A1 (de) | 1977-08-25 |
JPS52102094A (en) | 1977-08-26 |
CH612271A5 (en:Method) | 1979-07-13 |
FR2341866A1 (fr) | 1977-09-16 |
LU76810A1 (en:Method) | 1977-07-06 |
SE7701901L (sv) | 1977-08-21 |
BE851606A (fr) | 1977-06-16 |
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