CA1078767A - Process for producing defatted heparin tissue for heparin production - Google Patents
Process for producing defatted heparin tissue for heparin productionInfo
- Publication number
- CA1078767A CA1078767A CA264,457A CA264457A CA1078767A CA 1078767 A CA1078767 A CA 1078767A CA 264457 A CA264457 A CA 264457A CA 1078767 A CA1078767 A CA 1078767A
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- heparin
- defatted
- frozen
- heat exchanger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 78
- 229960002897 heparin Drugs 0.000 title claims abstract description 78
- 229920000669 heparin Polymers 0.000 title claims abstract description 77
- 238000000034 method Methods 0.000 title claims abstract description 42
- 238000004519 manufacturing process Methods 0.000 title description 4
- 238000000605 extraction Methods 0.000 claims abstract description 7
- 238000002955 isolation Methods 0.000 claims abstract description 7
- 210000004072 lung Anatomy 0.000 claims description 30
- 241001465754 Metazoa Species 0.000 claims description 17
- 238000000855 fermentation Methods 0.000 claims description 16
- 230000004151 fermentation Effects 0.000 claims description 16
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical group ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 claims description 13
- 235000015278 beef Nutrition 0.000 claims description 9
- 230000003750 conditioning effect Effects 0.000 claims description 5
- 238000010257 thawing Methods 0.000 claims description 5
- 238000010792 warming Methods 0.000 claims description 5
- 230000002255 enzymatic effect Effects 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 238000010899 nucleation Methods 0.000 claims description 3
- 239000003960 organic solvent Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 238000010533 azeotropic distillation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 description 12
- 238000005496 tempering Methods 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 244000005700 microbiome Species 0.000 description 5
- 235000019645 odor Nutrition 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 4
- 238000000227 grinding Methods 0.000 description 4
- 239000002510 pyrogen Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000013557 residual solvent Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- KNKRKFALVUDBJE-UHFFFAOYSA-N 1,2-dichloropropane Chemical compound CC(Cl)CCl KNKRKFALVUDBJE-UHFFFAOYSA-N 0.000 description 1
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical group ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
- 239000010868 animal carcass Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960002415 trichloroethylene Drugs 0.000 description 1
- UBOXGVDOUJQMTN-UHFFFAOYSA-N trichloroethylene Natural products ClCC(Cl)Cl UBOXGVDOUJQMTN-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62762575A | 1975-10-31 | 1975-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1078767A true CA1078767A (en) | 1980-06-03 |
Family
ID=24515411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA264,457A Expired CA1078767A (en) | 1975-10-31 | 1976-10-29 | Process for producing defatted heparin tissue for heparin production |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5257309A (ja) |
| AU (1) | AU512446B2 (ja) |
| CA (1) | CA1078767A (ja) |
| DE (1) | DE2646678C2 (ja) |
| DK (1) | DK490576A (ja) |
| FR (1) | FR2339625A1 (ja) |
| GB (1) | GB1505237A (ja) |
| IE (1) | IE44543B1 (ja) |
| IT (1) | IT1075976B (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2410084A (en) * | 1943-12-09 | 1946-10-29 | Upjohn Co | Recovery of heparin |
| US2539544A (en) * | 1950-01-03 | 1951-01-30 | Levin | Simultaneous defatting and dehydrating of fatty substances |
| US2884358A (en) * | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
-
1976
- 1976-10-15 DE DE2646678A patent/DE2646678C2/de not_active Expired
- 1976-10-22 IE IE2336/76A patent/IE44543B1/en unknown
- 1976-10-25 GB GB44251/76A patent/GB1505237A/en not_active Expired
- 1976-10-27 FR FR7632416A patent/FR2339625A1/fr active Granted
- 1976-10-29 CA CA264,457A patent/CA1078767A/en not_active Expired
- 1976-10-29 DK DK490576A patent/DK490576A/da not_active Application Discontinuation
- 1976-10-29 IT IT69611/76A patent/IT1075976B/it active
- 1976-10-29 JP JP51130389A patent/JPS5257309A/ja active Granted
- 1976-11-01 AU AU19189/76A patent/AU512446B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE44543L (en) | 1977-04-30 |
| JPS6115047B2 (ja) | 1986-04-22 |
| GB1505237A (en) | 1978-03-30 |
| IE44543B1 (en) | 1981-12-30 |
| JPS5257309A (en) | 1977-05-11 |
| AU512446B2 (en) | 1980-10-09 |
| FR2339625B1 (ja) | 1980-06-06 |
| DK490576A (da) | 1977-05-01 |
| FR2339625A1 (fr) | 1977-08-26 |
| DE2646678C2 (de) | 1985-11-28 |
| IT1075976B (it) | 1985-04-22 |
| DE2646678A1 (de) | 1977-05-05 |
| AU1918976A (en) | 1978-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |