IE44543L - Producing defatted tissue for heparin production - Google Patents
Producing defatted tissue for heparin productionInfo
- Publication number
- IE44543L IE44543L IE762336A IE233676A IE44543L IE 44543 L IE44543 L IE 44543L IE 762336 A IE762336 A IE 762336A IE 233676 A IE233676 A IE 233676A IE 44543 L IE44543 L IE 44543L
- Authority
- IE
- Ireland
- Prior art keywords
- heparin
- tissue
- degree
- defatted
- fat
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 6
- 229960002897 heparin Drugs 0.000 title abstract 6
- 229920000669 heparin Polymers 0.000 title abstract 6
- 238000000034 method Methods 0.000 abstract 2
- 238000010533 azeotropic distillation Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An improved process for producing defatted heparin tissue is disclosed wherein frozen heparin-bearing tissue is particulated, thawed and warmed in a heat exchanger, fermented at temperatures ranging from 45.degree.-95.degree.F. for 2 to 15 hours and subjected to azeotropic distillation and extraction to substantially remove water and fat. Putrefaction and odor are avoided, the tissue has improved uniformity in biochemical content, is lower in fat content and is capable of high heparin yields when processed according to known procedures. The defatted tissue is exceptionally permeable to heparin recovery solutions and heparin isolation is facilitated.
[CA1078767A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62762575A | 1975-10-31 | 1975-10-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44543L true IE44543L (en) | 1977-04-30 |
| IE44543B1 IE44543B1 (en) | 1981-12-30 |
Family
ID=24515411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2336/76A IE44543B1 (en) | 1975-10-31 | 1976-10-22 | Process for producing defatted heparin tissue for heparin production |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5257309A (en) |
| AU (1) | AU512446B2 (en) |
| CA (1) | CA1078767A (en) |
| DE (1) | DE2646678C2 (en) |
| DK (1) | DK490576A (en) |
| FR (1) | FR2339625A1 (en) |
| GB (1) | GB1505237A (en) |
| IE (1) | IE44543B1 (en) |
| IT (1) | IT1075976B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177887B (en) * | 1979-03-21 | 1982-01-28 | Richter Gedeon Vegyeszet | Process for preparing a raw material containing heparin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2410084A (en) * | 1943-12-09 | 1946-10-29 | Upjohn Co | Recovery of heparin |
| US2539544A (en) * | 1950-01-03 | 1951-01-30 | Levin | Simultaneous defatting and dehydrating of fatty substances |
| US2884358A (en) * | 1957-04-22 | 1959-04-28 | Southern California Gland Co | Process for preparing crude heparin |
-
1976
- 1976-10-15 DE DE2646678A patent/DE2646678C2/en not_active Expired
- 1976-10-22 IE IE2336/76A patent/IE44543B1/en unknown
- 1976-10-25 GB GB44251/76A patent/GB1505237A/en not_active Expired
- 1976-10-27 FR FR7632416A patent/FR2339625A1/en active Granted
- 1976-10-29 DK DK490576A patent/DK490576A/en not_active Application Discontinuation
- 1976-10-29 CA CA264,457A patent/CA1078767A/en not_active Expired
- 1976-10-29 JP JP51130389A patent/JPS5257309A/en active Granted
- 1976-10-29 IT IT69611/76A patent/IT1075976B/en active
- 1976-11-01 AU AU19189/76A patent/AU512446B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU1918976A (en) | 1978-05-11 |
| AU512446B2 (en) | 1980-10-09 |
| JPS6115047B2 (en) | 1986-04-22 |
| DK490576A (en) | 1977-05-01 |
| JPS5257309A (en) | 1977-05-11 |
| FR2339625A1 (en) | 1977-08-26 |
| DE2646678A1 (en) | 1977-05-05 |
| IT1075976B (en) | 1985-04-22 |
| FR2339625B1 (en) | 1980-06-06 |
| CA1078767A (en) | 1980-06-03 |
| DE2646678C2 (en) | 1985-11-28 |
| IE44543B1 (en) | 1981-12-30 |
| GB1505237A (en) | 1978-03-30 |
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