CA1069888A - Peptides having strong lh-rh/fsh-rh activity and process for their manufacture - Google Patents

Peptides having strong lh-rh/fsh-rh activity and process for their manufacture

Info

Publication number
CA1069888A
CA1069888A CA233,179A CA233179A CA1069888A CA 1069888 A CA1069888 A CA 1069888A CA 233179 A CA233179 A CA 233179A CA 1069888 A CA1069888 A CA 1069888A
Authority
CA
Canada
Prior art keywords
ser
pro
arg
solution
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA233,179A
Other languages
English (en)
French (fr)
Inventor
Wolfgang Konig
Rolf Geiger
Jurgen K. Sandow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1069888A publication Critical patent/CA1069888A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA233,179A 1974-08-09 1975-08-07 Peptides having strong lh-rh/fsh-rh activity and process for their manufacture Expired CA1069888A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2438350A DE2438350C3 (de) 1974-08-09 1974-08-09 Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (1)

Publication Number Publication Date
CA1069888A true CA1069888A (en) 1980-01-15

Family

ID=5922833

Family Applications (1)

Application Number Title Priority Date Filing Date
CA233,179A Expired CA1069888A (en) 1974-08-09 1975-08-07 Peptides having strong lh-rh/fsh-rh activity and process for their manufacture

Country Status (15)

Country Link
US (1) US4024248A (OSRAM)
JP (1) JPS5761268B2 (OSRAM)
AT (1) AT364093B (OSRAM)
BE (1) BE832310A (OSRAM)
CA (1) CA1069888A (OSRAM)
CH (1) CH613186A5 (OSRAM)
DE (1) DE2438350C3 (OSRAM)
DK (1) DK148905C (OSRAM)
FR (1) FR2281132A1 (OSRAM)
GB (1) GB1523623A (OSRAM)
IE (1) IE41510B1 (OSRAM)
IL (1) IL47880A (OSRAM)
LU (1) LU73166A1 (OSRAM)
NL (1) NL182051C (OSRAM)
SE (2) SE424184B (OSRAM)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
DE2735515A1 (de) * 1977-08-06 1979-02-22 Hoechst Ag Verwendung von lh-rh-peptiden als antikonzeptive
FR2450109B1 (fr) * 1977-11-08 1986-03-28 Roussel Uclaf Nouvelle methode de traitement utilisant la lh-rh, ou des agonistes
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
IT1149971B (it) * 1979-06-11 1986-12-10 Syntex Inc Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
DE3020941A1 (de) * 1980-06-03 1981-12-17 Hoechst Ag, 6000 Frankfurt Nonapeptid, verfahren zu seiner herstellung, dieses enthaltendes mittel und seine verwendung
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
HU187503B (en) * 1983-03-29 1986-01-28 Magyar Tudomanyos Akademia,Hu Process for preparing gonadoliberine derivatives containing beta-aspartyl group
AT390066B (de) * 1983-03-29 1990-03-12 Richter Gedeon Vegyeszet Verfahren zur herstellung von neuen gonadoliberin-derivaten
DE3411224A1 (de) * 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4775660A (en) * 1984-08-02 1988-10-04 Fernand Labrie Treatment of breast cancer by combination therapy
HU193093B (en) * 1985-04-16 1987-08-28 Innofinance Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
NZ244499A (en) * 1989-03-10 1999-05-28 Endorecherche Inc Treating breast or endometrial cancer with antiestrogen plus one of an androgen, a progestin and an inhibitor of sex steroid formation or secretion of prolactin, growth hormone or acth
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
JPH0235232A (ja) * 1989-06-29 1990-02-05 Nhk Spring Co Ltd 気室と液室を有する圧力容器
DE69032648T2 (de) * 1989-07-07 1999-04-08 Endorecherche Inc., Ste-Foy, Quebec Androgenderivate zur Hemming der Aktivität der Sexualsteroide
DE69034035T2 (de) * 1989-07-07 2004-01-22 Endorecherche Inc., Ste-Foy Methode zur behandlung androgenbedingter krankheiten
CA2029018A1 (en) * 1989-11-01 1991-05-02 Robert P. Millar Analogues of gonadotropin releasing hormone
JPH0474770U (OSRAM) * 1990-10-31 1992-06-30
AU4258493A (en) * 1992-05-21 1993-12-13 Endorecherche Inc. Inhibitors of testosterone 5alpha-reductase activity
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
ES2154590B1 (es) 1999-05-20 2001-11-01 Lipotec Sa Procedimiento de sintesis de peptidos en fase solida
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
JP2003137814A (ja) * 2001-08-10 2003-05-14 Takeda Chem Ind Ltd ＧｎＲＨアゴニストの併用剤
EP1444988A4 (en) 2001-11-13 2007-04-25 Takeda Pharmaceutical CANCER AGENT
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
GB0307777D0 (en) * 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
SI2767292T1 (sl) 2004-09-17 2017-01-31 Durect Corporation Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
KR101346886B1 (ko) 2005-01-21 2014-01-02 아스텍스 테라퓨틱스 리미티드 제약 화합물
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2117521B1 (en) 2006-11-03 2012-06-27 Durect Corporation Transdermal delivery systems comprising bupivacaine
EP2067471B1 (en) * 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
RU2444525C2 (ru) * 2010-06-09 2012-03-10 Закрытое Акционерное Общество "Фарм-Синтез" Способ получения нонапептидэтиламида и промежуточные соединения для его получения
WO2011156908A1 (en) 2010-06-16 2011-12-22 Endorecherche, Inc. Methods of treating or preventing estrogen-related diseases
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
JP7258561B2 (ja) 2016-07-06 2023-04-17 オリエント ファーマ シーオー．，エルティーディー． 薬物組成物、バリヤー層及び薬物層を有している経口投与形態
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
KR20230145053A (ko) 2021-01-12 2023-10-17 듀렉트 코퍼레이션 지속 방출 약물 전달 시스템 및 관련 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726506B2 (OSRAM) * 1974-03-08 1982-06-04
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US3901872A (en) * 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates

Also Published As

Publication number Publication date
IL47880A0 (en) 1975-11-25
DK361875A (da) 1976-02-10
CH613186A5 (OSRAM) 1979-09-14
SE424184B (sv) 1982-07-05
IE41510L (en) 1976-02-09
FR2281132B1 (OSRAM) 1979-09-14
DK148905C (da) 1986-04-07
AT364093B (de) 1981-09-25
AU8374475A (en) 1977-02-10
NL7509260A (nl) 1976-02-11
JPS5148659A (OSRAM) 1976-04-26
IE41510B1 (en) 1980-01-16
US4024248A (en) 1977-05-17
DE2438350C3 (de) 1979-06-13
ATA618975A (de) 1981-02-15
SE7508926L (sv) 1976-02-10
DE2438350B2 (de) 1978-10-26
FR2281132A1 (fr) 1976-03-05
BE832310A (fr) 1976-02-11
JPS5761268B2 (OSRAM) 1982-12-23
IL47880A (en) 1978-10-31
NL182051C (nl) 1988-01-04
SE7805545L (OSRAM) 1978-05-16
GB1523623A (en) 1978-09-06
LU73166A1 (OSRAM) 1977-04-13
DE2438350A1 (de) 1976-02-26
NL182051B (nl) 1987-08-03
DK148905B (da) 1985-11-11

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Legal Events

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