CA1064942A - Composes de pyroglutamy antidepresseurs et procede de fabrication - Google Patents

Composes de pyroglutamy antidepresseurs et procede de fabrication

Info

Publication number
CA1064942A
CA1064942A CA227,255A CA227255A CA1064942A CA 1064942 A CA1064942 A CA 1064942A CA 227255 A CA227255 A CA 227255A CA 1064942 A CA1064942 A CA 1064942A
Authority
CA
Canada
Prior art keywords
formula
acid
pyroglutamyl
compound
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA227,255A
Other languages
English (en)
Inventor
Hans Wissmann
Hansjorg Kruse
Wolfgang Konig
Rolf Geiger
Michel Peterfalvi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1064942A publication Critical patent/CA1064942A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173—Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA227,255A 1974-05-14 1975-05-13 Composes de pyroglutamy antidepresseurs et procede de fabrication Expired CA1064942A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2423390A DE2423390A1 (de) 1974-05-14 1974-05-14 Pyroglutamylverbindungen mit antidepressiver wirkung und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CA1064942A true CA1064942A (fr) 1979-10-23

Family

ID=5915523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA227,255A Expired CA1064942A (fr) 1974-05-14 1975-05-13 Composes de pyroglutamy antidepresseurs et procede de fabrication

Country Status (14)

Country Link
JP (1) JPS50157362A (fr)
AT (2) AT352707B (fr)
BE (1) BE829059A (fr)
CA (1) CA1064942A (fr)
CH (2) CH613689A5 (fr)
DE (1) DE2423390A1 (fr)
DK (1) DK209575A (fr)
FR (1) FR2270866B1 (fr)
GB (1) GB1472154A (fr)
IE (1) IE41145B1 (fr)
IL (1) IL47258A (fr)
LU (1) LU72450A1 (fr)
NL (1) NL7505473A (fr)
SE (1) SE405113B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004244A1 (fr) * 1994-08-05 1996-02-15 Warwick International Group Limited Activateurs de blanchiment
US6420427B1 (en) * 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
RU2232578C1 (ru) * 2003-04-10 2004-07-20 Ахапкина Валентина Ивановна Вещество, обладающее антидепрессивной активностью

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220996B2 (fr) * 1972-01-14 1977-06-07
JPS5015793B2 (fr) * 1972-06-07 1975-06-07

Also Published As

Publication number Publication date
FR2270866A1 (fr) 1975-12-12
JPS50157362A (fr) 1975-12-19
IE41145L (en) 1975-11-14
ATA364875A (de) 1979-03-15
AT364875B (de) 1979-03-15
SE7505546L (sv) 1975-11-17
AT352707B (de) 1979-10-10
BE829059A (fr) 1975-11-14
IE41145B1 (en) 1979-10-24
CH613689A5 (en) 1979-10-15
GB1472154A (en) 1977-05-04
CH612180A5 (en) 1979-07-13
ATA13179A (de) 1981-04-15
DE2423390A1 (de) 1975-12-04
NL7505473A (nl) 1975-11-18
LU72450A1 (fr) 1977-02-09
IL47258A (en) 1978-07-31
DK209575A (da) 1975-11-15
FR2270866B1 (fr) 1978-08-04
SE405113B (sv) 1978-11-20
IL47258A0 (en) 1975-07-28

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