CA1064942A - Pyroglutamy compounds having antidepressive activity and process for their manufacture - Google Patents

Pyroglutamy compounds having antidepressive activity and process for their manufacture

Info

Publication number
CA1064942A
CA1064942A CA227,255A CA227255A CA1064942A CA 1064942 A CA1064942 A CA 1064942A CA 227255 A CA227255 A CA 227255A CA 1064942 A CA1064942 A CA 1064942A
Authority
CA
Canada
Prior art keywords
formula
acid
pyroglutamyl
compound
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA227,255A
Other languages
English (en)
French (fr)
Inventor
Hans Wissmann
Hansjorg Kruse
Wolfgang Konig
Rolf Geiger
Michel Peterfalvi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of CA1064942A publication Critical patent/CA1064942A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2732-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/282-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • C07K5/06173Dipeptides with the first amino acid being heterocyclic and Glp-amino acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA227,255A 1974-05-14 1975-05-13 Pyroglutamy compounds having antidepressive activity and process for their manufacture Expired CA1064942A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2423390A DE2423390A1 (de) 1974-05-14 1974-05-14 Pyroglutamylverbindungen mit antidepressiver wirkung und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
CA1064942A true CA1064942A (en) 1979-10-23

Family

ID=5915523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA227,255A Expired CA1064942A (en) 1974-05-14 1975-05-13 Pyroglutamy compounds having antidepressive activity and process for their manufacture

Country Status (14)

Country Link
JP (1) JPS50157362A (es)
AT (2) AT352707B (es)
BE (1) BE829059A (es)
CA (1) CA1064942A (es)
CH (2) CH613689A5 (es)
DE (1) DE2423390A1 (es)
DK (1) DK209575A (es)
FR (1) FR2270866B1 (es)
GB (1) GB1472154A (es)
IE (1) IE41145B1 (es)
IL (1) IL47258A (es)
LU (1) LU72450A1 (es)
NL (1) NL7505473A (es)
SE (1) SE405113B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3184395A (en) * 1994-08-05 1996-03-04 Warwick International Group Limited Bleach activators
US6420427B1 (en) * 1997-10-09 2002-07-16 Ono Pharmaceutical Co., Ltd. Aminobutyric acid derivatives
RU2232578C1 (ru) * 2003-04-10 2004-07-20 Ахапкина Валентина Ивановна Вещество, обладающее антидепрессивной активностью

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5220996B2 (es) * 1972-01-14 1977-06-07
JPS5015793B2 (es) * 1972-06-07 1975-06-07

Also Published As

Publication number Publication date
AT352707B (de) 1979-10-10
NL7505473A (nl) 1975-11-18
SE7505546L (sv) 1975-11-17
JPS50157362A (es) 1975-12-19
FR2270866B1 (es) 1978-08-04
IE41145B1 (en) 1979-10-24
LU72450A1 (es) 1977-02-09
CH613689A5 (en) 1979-10-15
CH612180A5 (en) 1979-07-13
FR2270866A1 (es) 1975-12-12
DE2423390A1 (de) 1975-12-04
GB1472154A (en) 1977-05-04
IL47258A (en) 1978-07-31
ATA364875A (de) 1979-03-15
ATA13179A (de) 1981-04-15
IL47258A0 (en) 1975-07-28
AT364875B (de) 1979-03-15
BE829059A (fr) 1975-11-14
DK209575A (da) 1975-11-15
SE405113B (sv) 1978-11-20
IE41145L (en) 1975-11-14

Similar Documents

Publication Publication Date Title
US4053588A (en) Pharmaceutical preparations having psychotropic activity and process for their manufacture
US4619916A (en) Tripeptide compounds containing pyroglutamic acid and tryptophan, process for their production and therapeutic applications
JPH06340691A (ja) ペプチド類
GB1592552A (en) Pseudopeptides used as medicaments
US4298523A (en) Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
CH650519A5 (de) Auf das zentrale nervensystem wirkende tripeptide und verfahren zur herstellung derselben.
US4216209A (en) Tripeptide angiotensin converting enzyme inhibitors
GB2127830A (en) Amides of tripeptides and tetrapeptides
GB2086912A (en) Enkephalin derivatives production thereof and pharmaceutical compositions
CA1064942A (en) Pyroglutamy compounds having antidepressive activity and process for their manufacture
JPS5811941B2 (ja) ブラディキニン環状類似体
CA1158236A (en) Process for the preparation of novel substituted phenylacetic acid amide compounds
NZ202784A (en) Enkephalin derivatives and pharmaceutical compositions
CA1062250A (en) Tripeptide derivatives with central nervous system activity and preparation thereof
DE1518133B1 (de) Verfahren zur Herstellung eines neuen hypotensiv wirkenden Hendekapeptids
JPH0647599B2 (ja) ヘプタノイル―Glu―Asp―Ala―アミノ酸系免疫賦活薬
US4369137A (en) N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide
GB2130590A (en) Peptides
DE3340208A1 (de) Neue biologisch aktive peptide, verfahren zu deren herstellung und veterinaerpraeparate, welche diese enthalten
EP0004394B1 (en) Psychopharmacological peptides, process for their preparation and their pharmaceutical formulations
FI64349B (fi) Foerfarande foer framstaellning av ett terapeutiskt anvaendbart l-pyroglutamyl-l-histidyl-glycin och dess salter
US3780014A (en) Octapeptide intermediate to gonadotropin releasing hormone
US3790555A (en) Octapeptide derivative of gonadotropinreleasing hormone
EP0015036B1 (en) Psycho-pharmacological peptides, process for their preparation and therapeutical compositions containing them
DE68913936T2 (de) Retro-Inverso-Thrymopentin-Analoge, Verfahren zu deren Herstellung und deren Verwendung für die Zubereitung von pharmazeutischen Zusammensetzungen.