CA1059127A - Benzylpyrimidines - Google Patents

Benzylpyrimidines

Info

Publication number
CA1059127A
CA1059127A CA242,038A CA242038A CA1059127A CA 1059127 A CA1059127 A CA 1059127A CA 242038 A CA242038 A CA 242038A CA 1059127 A CA1059127 A CA 1059127A
Authority
CA
Canada
Prior art keywords
group
methyl
bis
ethyl acetate
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA242,038A
Other languages
English (en)
French (fr)
Inventor
Gerald Rey-Bellett
Ivan Kompis
Guido Zanetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of CA1059127A publication Critical patent/CA1059127A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CA242,038A 1974-12-24 1975-12-18 Benzylpyrimidines Expired CA1059127A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1728774A CH605828A5 (sv) 1974-12-24 1974-12-24

Publications (1)

Publication Number Publication Date
CA1059127A true CA1059127A (en) 1979-07-24

Family

ID=4424233

Family Applications (1)

Application Number Title Priority Date Filing Date
CA242,038A Expired CA1059127A (en) 1974-12-24 1975-12-18 Benzylpyrimidines

Country Status (25)

Country Link
JP (1) JPS5191273A (sv)
AT (1) AT344704B (sv)
AU (1) AU500102B2 (sv)
BE (1) BE836996A (sv)
BR (1) BR7508534A (sv)
CA (1) CA1059127A (sv)
CH (2) CH605828A5 (sv)
CU (1) CU34406A (sv)
DD (1) DD123603A5 (sv)
DE (1) DE2558150A1 (sv)
DK (1) DK137797B (sv)
ES (1) ES443790A1 (sv)
FI (1) FI753312A (sv)
FR (1) FR2295750A1 (sv)
GB (1) GB1492140A (sv)
HU (1) HU174324B (sv)
IL (1) IL48416A (sv)
LU (1) LU73971A1 (sv)
NL (1) NL7514269A (sv)
NO (1) NO141408C (sv)
PH (1) PH12314A (sv)
PL (1) PL101046B1 (sv)
SE (1) SE417607B (sv)
SU (1) SU612629A3 (sv)
ZA (1) ZA756964B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR71725B (sv) * 1977-11-10 1983-06-22 Hoffmann La Roche
NZ713361A (en) 2009-08-17 2017-06-30 Memorial Sloan Kettering Cancer Center Heat shock protein binding compounds, compositions, and methods for making and using same
EP3143013B1 (en) 2014-05-13 2019-12-18 Memorial Sloan Kettering Cancer Center Hsp70 modulators and methods for making and using the same

Also Published As

Publication number Publication date
PH12314A (en) 1979-01-16
GB1492140A (en) 1977-11-16
ZA756964B (en) 1976-10-27
DE2558150A1 (de) 1976-07-01
AU8643375A (en) 1977-05-12
LU73971A1 (sv) 1977-07-01
BE836996A (fr) 1976-06-23
DD123603A5 (sv) 1977-01-05
SE417607B (sv) 1981-03-30
FI753312A (sv) 1976-06-25
NO141408C (no) 1980-03-05
NO754372L (sv) 1976-06-25
AT344704B (de) 1978-08-10
CH605828A5 (sv) 1978-10-13
BR7508534A (pt) 1976-12-21
ATA975975A (de) 1977-12-15
CH617191A5 (en) 1980-05-14
FR2295750A1 (fr) 1976-07-23
FR2295750B1 (sv) 1980-06-20
DK137797B (da) 1978-05-08
SE7514642L (sv) 1976-06-28
AU500102B2 (en) 1979-05-10
DK589675A (sv) 1976-06-25
NO141408B (no) 1979-11-26
SU612629A3 (ru) 1978-06-25
CU34406A (es) 1978-09-08
HU174324B (hu) 1979-12-28
IL48416A (en) 1980-02-29
PL101046B1 (pl) 1978-11-30
IL48416A0 (en) 1976-01-30
JPS5191273A (sv) 1976-08-10
ES443790A1 (es) 1977-12-16
DK137797C (sv) 1978-10-16
NL7514269A (nl) 1976-06-28

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