CA1056685A - Active agent dispenser and process for making same - Google Patents

Active agent dispenser and process for making same

Info

Publication number
CA1056685A
CA1056685A CA239,459A CA239459A CA1056685A CA 1056685 A CA1056685 A CA 1056685A CA 239459 A CA239459 A CA 239459A CA 1056685 A CA1056685 A CA 1056685A
Authority
CA
Canada
Prior art keywords
active agent
dispenser
lamina
drug
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA239,459A
Other languages
English (en)
French (fr)
Inventor
Robert M. Gale
Richard W. Baker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of CA1056685A publication Critical patent/CA1056685A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA239,459A 1974-11-14 1975-11-12 Active agent dispenser and process for making same Expired CA1056685A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US523720A US3926188A (en) 1974-11-14 1974-11-14 Laminated drug dispenser

Publications (1)

Publication Number Publication Date
CA1056685A true CA1056685A (en) 1979-06-19

Family

ID=24086191

Family Applications (1)

Application Number Title Priority Date Filing Date
CA239,459A Expired CA1056685A (en) 1974-11-14 1975-11-12 Active agent dispenser and process for making same

Country Status (10)

Country Link
US (1) US3926188A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6059203B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1056685A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH634226A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2549856C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2290891A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1477813A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1050619B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (2) MX158868A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE439432B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182330A (en) * 1977-07-25 1980-01-08 Alza Corporation Means for administering amphipathic medicament
US4304232A (en) * 1979-03-14 1981-12-08 Alza Corporation Unit system having multiplicity of means for dispensing useful agent
RO86519B (ro) * 1979-09-12 1985-03-31 Eli Lilly And Company Dispozitiv pentru rumegatoare
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
DE3115763A1 (de) * 1981-04-18 1982-11-04 Edgar Dr.med. 6238 Hofheim Lenhard Medizinische depotsonde zur lokalen protrahierten wirkstoffreisetzung
US4370313A (en) * 1981-10-26 1983-01-25 Eaton Laboratories, Inc. Nitrofurantoin dosage form
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
US4571039A (en) * 1983-04-15 1986-02-18 Stanley Poler Eye-medicating contact-lens construction
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4564364A (en) * 1983-05-26 1986-01-14 Alza Corporation Active agent dispenser
US4601893A (en) * 1984-02-08 1986-07-22 Pfizer Inc. Laminate device for controlled and prolonged release of substances to an ambient environment and method of use
US4863445A (en) * 1984-07-30 1989-09-05 Baxter Travenol Laboratories, Inc. Assembly for inhibiting microbial growth in collected fluid
US4693895A (en) * 1984-10-26 1987-09-15 Alza Corporation Colon delivery system
US4627851A (en) * 1984-10-26 1986-12-09 Alza Corporation Colonic-therapeutic delivery system
CH667001A5 (de) * 1985-09-03 1988-09-15 Hugo Degen Untermatratze.
US4880633A (en) * 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4938759A (en) * 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4830860A (en) * 1986-10-30 1989-05-16 Pfizer Inc. Stressed polymeric device for controlled release of a substance to an ambient environment
JPS63143581A (ja) * 1986-12-05 1988-06-15 Nissha Printing Co Ltd ホログラム成型品
US4892778A (en) * 1987-05-27 1990-01-09 Alza Corporation Juxtaposed laminated arrangement
EP0303306B1 (en) * 1987-08-08 1993-03-10 Akzo N.V. Contraceptive implant
DK530787D0 (da) * 1987-10-09 1987-10-09 Bukh Meditec Indretning til indfoering i en legemshulhed
US5035886A (en) * 1987-10-19 1991-07-30 Ppg Industries, Inc. Active agent delivery device
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
US5071645A (en) * 1987-10-19 1991-12-10 Ppg Industries, Inc. Process of producing an active agent delivery device
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
GB8815968D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Veterinary devices
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5217718A (en) * 1989-08-18 1993-06-08 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5124157A (en) 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
EP0542915A1 (en) * 1990-08-09 1993-05-26 Endocon, Inc. Multiple drug delivery system
JPH0444601U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-08-22 1992-04-15
JPH0444666U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1990-08-22 1992-04-15
US5538735A (en) * 1993-02-19 1996-07-23 Ahn; Sam S. Method of making a drug delivery system using hollow fibers
JP3720386B2 (ja) * 1993-12-27 2005-11-24 住友製薬株式会社 薬物放出制御製剤
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5660848A (en) * 1994-11-02 1997-08-26 The Population Council, Center For Biomedical Research Subdermally implantable device
WO2001089486A1 (fr) * 2000-05-26 2001-11-29 Kanji Takada Preparation administrable autrement que par la voie orale a structure a trois couches
US20020148138A1 (en) * 2001-04-06 2002-10-17 Egan Brian A. Smart tread boot covers
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
US7306580B2 (en) * 2003-04-16 2007-12-11 Cook Incorporated Medical device with therapeutic agents
EP1646363B1 (en) * 2003-07-10 2013-10-16 Warner Chilcott (Ireland) Limited Intravaginal drug delivery devices
KR20060085246A (ko) * 2003-09-18 2006-07-26 마커사이트, 인코포레이티드 경공막 전달
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
DE102004050457A1 (de) * 2004-10-12 2006-04-13 Capsulution Nanoscience Ag Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben
KR101492584B1 (ko) 2005-02-09 2015-02-11 산텐 세이야꾸 가부시키가이샤 질환 또는 상태의 치료를 위한 액체 제제
US8663639B2 (en) 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
EP2001438A2 (en) 2006-02-09 2008-12-17 Macusight, Inc. Stable formulations, and methods of their preparation and use
CN103127100A (zh) 2006-03-23 2013-06-05 参天制药株式会社 用于与血管通透性有关的疾病或病症的制剂和方法
CN102365109B (zh) 2009-01-29 2015-06-03 弗赛特影像4股份有限公司 后段给药
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CN102596097B (zh) 2009-06-03 2015-05-20 弗赛特实验室有限责任公司 一种眼插入件
US20110066141A1 (en) * 2009-09-11 2011-03-17 Cook Incorporated Implantable medical device having an anti-gastric distress agent
US20110098797A1 (en) * 2009-10-23 2011-04-28 Cleek Robert L Drug eluting composite
US9320890B2 (en) * 2009-11-09 2016-04-26 W. L. Gore & Associates, Inc. Drug eluting composite
US9504771B2 (en) 2009-11-09 2016-11-29 W. L. Gore & Associates, Inc. Drug eluting composite
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
PT2547332T (pt) 2010-03-16 2018-11-27 Titan Pharmaceuticals Inc Dispositivos implantáveis heterogéneos para libertação de fármacos
US8939948B2 (en) 2010-06-01 2015-01-27 Forsight Vision5, Inc. Ocular insert apparatus and methods
CN103153316B (zh) 2010-08-05 2015-08-19 弗赛特影像4股份有限公司 组合药物递送方法和设备
RS62540B1 (sr) 2010-08-05 2021-12-31 Forsight Vision4 Inc Aparat za lečenje oka
SG187730A1 (en) 2010-08-05 2013-03-28 Forsight Vision 4 Inc Injector apparatus and method for drug delivery
WO2012068549A2 (en) 2010-11-19 2012-05-24 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
RS61758B1 (sr) 2011-09-16 2021-05-31 Forsight Vision4 Inc Aparati za razmenu tečnosti
US20140271783A1 (en) * 2011-10-14 2014-09-18 Purdue Research Foundation Prefabricated pharmaceutical dosage forms from functional polymer films
PL2911623T3 (pl) 2012-10-26 2020-03-31 Forsight Vision5, Inc. System oczny do przedłużonego uwalniania leku do oka
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
EP4302736A3 (en) 2013-03-28 2024-04-03 ForSight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
SG11201700943TA (en) 2014-08-08 2017-03-30 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10226419B2 (en) * 2014-09-08 2019-03-12 ProMed Pharma, LLC Methods for manufacturing implants
JP7037360B2 (ja) 2014-11-10 2022-03-16 フォーサイト・ビジョン フォー・インコーポレーテッド 拡張可能な薬物送達デバイス
WO2016168141A1 (en) 2015-04-13 2016-10-20 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
CN113069681B (zh) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
WO2017176886A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
AU2018372806B2 (en) 2017-11-21 2024-05-30 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB906422A (en) * 1958-05-02 1962-09-19 Wellcome Found Improvements in and relating to prolonged acting pharmaceutical preparations
US2928770A (en) * 1958-11-28 1960-03-15 Frank M Bardani Sustained action pill
US3416530A (en) * 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3854480A (en) * 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3618604A (en) * 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3630200A (en) * 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3832252A (en) * 1970-09-29 1974-08-27 T Higuchi Method of making a drug-delivery device
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US3851648A (en) * 1973-10-11 1974-12-03 Mead Johnson & Co Zero-order release device

Also Published As

Publication number Publication date
FR2290891B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-11-10
SE439432B (sv) 1985-06-17
GB1477813A (en) 1977-06-29
IT1050619B (it) 1981-03-20
SE7512744L (sv) 1977-05-15
JPS6059203B2 (ja) 1985-12-24
US3926188A (en) 1975-12-16
DE2549856C2 (de) 1985-01-03
JPS5170807A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-06-18
MX158867A (es) 1989-03-27
FR2290891A1 (fr) 1976-06-11
MX158868A (es) 1989-03-27
CH634226A5 (de) 1983-01-31
DE2549856A1 (de) 1976-05-20

Similar Documents

Publication Publication Date Title
CA1056685A (en) Active agent dispenser and process for making same
CA1047403A (en) Process for making a monolithic drug delivery device
AU670410B2 (en) Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset
US4911707A (en) Monolithic user-activated transdermal therapeutic system
US4917676A (en) User-activated transdermal therapeutic system
US3995631A (en) Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
CA1133853A (en) Article for the dispensing of volatiles
US5273755A (en) Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset
FI95539B (fi) Transdermaalinen järjestelmä, sen valmistusmenetelmä ja käyttö
DE60201815T2 (de) Vorrichtung zur verabreichung von medikamenten in die atemwege
US5254346A (en) Occlusive body for administering a physiologically active substance
CA1078734A (en) Controlled release article
US4445641A (en) Controlled-release dispenser
US5071704A (en) Device for controlled release of vapors and scents
AU732273B2 (en) Controlled release of substances
US4034756A (en) Osmotically driven fluid dispenser
CA2133598C (en) Non-occlusive adhesive patch for applying medication to the skin
US4830860A (en) Stressed polymeric device for controlled release of a substance to an ambient environment
CA1084839A (en) Active agent delivery systems made from certain segmented copolyesters
WO1995015158A1 (de) Wirkstoffhaltiges pflaster
JPH03505044A (ja) プリントされた皮膚透過性薬剤投与具
EP0093262A1 (en) Article for the dispersion of a volatile substance and an article of manufacture comprising a plurality of said articles
AU614728B2 (en) User-activated transdermal therapeutic systems
EP0384267A2 (de) Therapeutisches System zur verzögerten und gesteuerten transdermalen oder transmucosalen Verabreichung von Wirkstoffen
CA1083041A (en) Sustained release drug delivery device and process for making same