CA1051429A - Certain 6h-pyrimido (1,2-c) (1,3,5) benzothiadiazo compounds - Google Patents

Certain 6h-pyrimido (1,2-c) (1,3,5) benzothiadiazo compounds

Info

Publication number
CA1051429A
CA1051429A CA203,661A CA203661A CA1051429A CA 1051429 A CA1051429 A CA 1051429A CA 203661 A CA203661 A CA 203661A CA 1051429 A CA1051429 A CA 1051429A
Authority
CA
Canada
Prior art keywords
compound
carbons
pyrimido
bromo
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA203,661A
Other languages
English (en)
French (fr)
Other versions
CA203661S (en
Inventor
Harry L. Yale
Ramesh B. Petigara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of CA1051429A publication Critical patent/CA1051429A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA203,661A 1973-07-26 1974-06-28 Certain 6h-pyrimido (1,2-c) (1,3,5) benzothiadiazo compounds Expired CA1051429A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US382802A US3875162A (en) 1973-07-26 1973-07-26 Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds

Publications (1)

Publication Number Publication Date
CA1051429A true CA1051429A (en) 1979-03-27

Family

ID=23510466

Family Applications (1)

Application Number Title Priority Date Filing Date
CA203,661A Expired CA1051429A (en) 1973-07-26 1974-06-28 Certain 6h-pyrimido (1,2-c) (1,3,5) benzothiadiazo compounds

Country Status (6)

Country Link
US (1) US3875162A (ja)
JP (1) JPS5041892A (ja)
CA (1) CA1051429A (ja)
DE (1) DE2435382A1 (ja)
FR (1) FR2238491B1 (ja)
GB (1) GB1476684A (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966733A (en) * 1973-07-26 1976-06-29 E. R. Squibb & Sons, Inc. Intermediates for certain benzothiadiazepine and benzothiadiazocine compounds
MX2011008328A (es) 2009-02-05 2011-11-04 Immunogen Inc Derivados novedosos de benzodiacepina.
DK2675479T3 (en) 2011-02-15 2016-04-11 Immunogen Inc cytotoxic benzodiazepine
WO2014031566A1 (en) 2012-08-22 2014-02-27 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
WO2016036804A1 (en) 2014-09-03 2016-03-10 Immunogen, Inc. Cytotoxic benzodiazepine derivatives
SG11201701455SA (en) 2014-09-03 2017-03-30 Immunogen Inc Cytotoxic benzodiazepine derivatives
SG11201909564XA (en) 2017-04-20 2019-11-28 Immunogen Inc Methods of preparing indolinobenzodiazepine derivatives
US20180346488A1 (en) 2017-04-20 2018-12-06 Immunogen, Inc. Cytotoxic benzodiazepine derivatives and conjugates thereof
EP3732178A1 (en) 2017-12-28 2020-11-04 ImmunoGen, Inc. Benzodiazepine derivatives
CN113661172A (zh) 2019-03-29 2021-11-16 伊缪诺金公司 用于抑制异常细胞生长或治疗增生性疾病的细胞毒性双苯并二氮杂䓬衍生物及其与细胞结合剂的缀合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH530412A (de) * 1968-07-15 1972-11-15 Ciba Geigy Ag Verfahren zur Herstellung von (1)Benzothieno-(2,3-d)pyrimidinen
GB1275804A (en) * 1969-07-03 1972-05-24 Seperic Improvements in or relating to new sulphur containing derivatives of pyrimidine, their preparation and their applications
US3704303A (en) * 1971-03-17 1972-11-28 American Home Prod 6,7,8,9 - tetrahydropyrimido(2,1-b) - benzothiazole-6-carboxylic acid,alkyl esters

Also Published As

Publication number Publication date
FR2238491B1 (ja) 1978-07-28
DE2435382A1 (de) 1975-02-13
JPS5041892A (ja) 1975-04-16
GB1476684A (en) 1977-06-16
US3875162A (en) 1975-04-01
FR2238491A1 (ja) 1975-02-21

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