JPS5041892A - - Google Patents
Info
- Publication number
- JPS5041892A JPS5041892A JP49086507A JP8650774A JPS5041892A JP S5041892 A JPS5041892 A JP S5041892A JP 49086507 A JP49086507 A JP 49086507A JP 8650774 A JP8650774 A JP 8650774A JP S5041892 A JPS5041892 A JP S5041892A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US382802A US3875162A (en) | 1973-07-26 | 1973-07-26 | Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5041892A true JPS5041892A (ja) | 1975-04-16 |
Family
ID=23510466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP49086507A Pending JPS5041892A (ja) | 1973-07-26 | 1974-07-26 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3875162A (ja) |
| JP (1) | JPS5041892A (ja) |
| CA (1) | CA1051429A (ja) |
| DE (1) | DE2435382A1 (ja) |
| FR (1) | FR2238491B1 (ja) |
| GB (1) | GB1476684A (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966733A (en) * | 1973-07-26 | 1976-06-29 | E. R. Squibb & Sons, Inc. | Intermediates for certain benzothiadiazepine and benzothiadiazocine compounds |
| AU2010210646B2 (en) | 2009-02-05 | 2015-10-29 | Immunogen, Inc. | Novel benzodiazepine derivatives |
| SI2675479T1 (sl) * | 2011-02-15 | 2016-04-29 | Immunogen, Inc. | Citotoksični derivati benzodiazepina |
| EP2887965A1 (en) | 2012-08-22 | 2015-07-01 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| US9381256B2 (en) | 2014-09-03 | 2016-07-05 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
| CN116514903A (zh) | 2014-09-03 | 2023-08-01 | 伊缪诺金公司 | 细胞毒性苯并二氮杂䓬衍生物 |
| IL311609A (en) | 2017-04-20 | 2024-05-01 | Immunogen Inc | Methods for the preparation of indolinobenzodiazepine derivatives |
| US20180346488A1 (en) | 2017-04-20 | 2018-12-06 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
| EP3732178A1 (en) | 2017-12-28 | 2020-11-04 | ImmunoGen, Inc. | Benzodiazepine derivatives |
| JP2022529583A (ja) | 2019-03-29 | 2022-06-23 | イミュノジェン・インコーポレーテッド | 異常細胞増殖を阻害するまたは増殖性疾患を治療するための細胞毒性ビス－ベンゾジアゼピン誘導体及び細胞結合剤とのその複合体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH530412A (de) * | 1968-07-15 | 1972-11-15 | Ciba Geigy Ag | Verfahren zur Herstellung von (1)Benzothieno-(2,3-d)pyrimidinen |
| GB1275804A (en) * | 1969-07-03 | 1972-05-24 | Seperic | Improvements in or relating to new sulphur containing derivatives of pyrimidine, their preparation and their applications |
| US3704303A (en) * | 1971-03-17 | 1972-11-28 | American Home Prod | 6,7,8,9 - tetrahydropyrimido(2,1-b) - benzothiazole-6-carboxylic acid,alkyl esters |
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1973
- 1973-07-26 US US382802A patent/US3875162A/en not_active Expired - Lifetime
-
1974
- 1974-06-28 CA CA203,661A patent/CA1051429A/en not_active Expired
- 1974-07-03 GB GB2952174A patent/GB1476684A/en not_active Expired
- 1974-07-23 DE DE2435382A patent/DE2435382A1/de not_active Withdrawn
- 1974-07-26 FR FR7426130A patent/FR2238491B1/fr not_active Expired
- 1974-07-26 JP JP49086507A patent/JPS5041892A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US3875162A (en) | 1975-04-01 |
| FR2238491B1 (ja) | 1978-07-28 |
| CA1051429A (en) | 1979-03-27 |
| GB1476684A (en) | 1977-06-16 |
| FR2238491A1 (ja) | 1975-02-21 |
| DE2435382A1 (de) | 1975-02-13 |