CA1047032A - Adriamycin esters - Google Patents

Adriamycin esters

Info

Publication number
CA1047032A
CA1047032A CA255,213A CA255213A CA1047032A CA 1047032 A CA1047032 A CA 1047032A CA 255213 A CA255213 A CA 255213A CA 1047032 A CA1047032 A CA 1047032A
Authority
CA
Canada
Prior art keywords
adriamycin
esters
hydrochloride
activity
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA255,213A
Other languages
English (en)
French (fr)
Inventor
Federico Arcamone
Aurelio Di Marco
Bianca Patelli
Luigi Bernardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Application granted granted Critical
Publication of CA1047032A publication Critical patent/CA1047032A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA255,213A 1975-06-20 1976-06-18 Adriamycin esters Expired CA1047032A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB26271/75A GB1499026A (en) 1975-06-20 1975-06-20 Adriamycin esters

Publications (1)

Publication Number Publication Date
CA1047032A true CA1047032A (en) 1979-01-23

Family

ID=10241028

Family Applications (1)

Application Number Title Priority Date Filing Date
CA255,213A Expired CA1047032A (en) 1975-06-20 1976-06-18 Adriamycin esters

Country Status (15)

Country Link
US (1) US4031211A (enExample)
JP (1) JPS525756A (enExample)
AT (1) AT342772B (enExample)
AU (1) AU502848B2 (enExample)
BE (1) BE843120A (enExample)
CA (1) CA1047032A (enExample)
CH (1) CH623830A5 (enExample)
DE (1) DE2627146C3 (enExample)
DK (1) DK270876A (enExample)
FR (1) FR2314727A1 (enExample)
GB (1) GB1499026A (enExample)
NL (1) NL7606455A (enExample)
SE (1) SE7606971L (enExample)
SU (1) SU667143A3 (enExample)
ZA (1) ZA763548B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL170737C (nl) * 1975-11-12 1982-12-16 Rhone Poulenc Ind Werkwijze voor het bereiden van tegen tumoren werkzame esters van adriamycine, alsmede voor het bereiden van geneesmiddelen met anti-tumoractiviteit.
GB1511680A (en) * 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
GB1518390A (en) * 1976-03-30 1978-07-19 Farmaceutici Italia Doxorubicin thioesters
US4277466A (en) * 1978-08-29 1981-07-07 Institut International De Pathologie Cellulaire Et Moleculaire Complexes of DNA and esters derived from daunorubicine, their preparation and use
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
DE3500017A1 (de) * 1985-01-02 1986-07-10 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-haloanthracyclinester
DE3500023A1 (de) * 1985-01-02 1986-07-10 Farmitalia Carlo Erba S.p.A., Mailand/Milano 4'-desoxyanthracyclinester
DE3500029A1 (de) * 1985-01-02 1986-09-04 Farmitalia Carlo Erba S.p.A., Mailand/Milano Anthracyclinester
GB2169286A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxy-4'-halodoxorubicin-14-esters
GB2169285A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Deoxydoxorubicin-14-esters
GB2169284A (en) * 1985-01-05 1986-07-09 Erba Farmitalia 4'-Epidoxorubicin-14-esters
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
EP2061900A2 (en) 2006-08-25 2009-05-27 Oncotherapy Science, Inc. Prognostic markers and therapeutic targets for lung cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives

Also Published As

Publication number Publication date
JPS5610918B2 (enExample) 1981-03-11
ZA763548B (en) 1977-07-27
FR2314727B1 (enExample) 1978-10-20
DK270876A (da) 1976-12-21
JPS525756A (en) 1977-01-17
AU502848B2 (en) 1979-08-09
SE7606971L (sv) 1976-12-21
DE2627146B2 (de) 1978-06-29
AT342772B (de) 1978-04-25
FR2314727A1 (fr) 1977-01-14
BE843120A (fr) 1976-10-18
US4031211A (en) 1977-06-21
NL7606455A (nl) 1976-12-22
DE2627146C3 (de) 1979-03-01
GB1499026A (en) 1978-01-25
SU667143A3 (ru) 1979-06-05
AU1500776A (en) 1977-12-22
CH623830A5 (enExample) 1981-06-30
DE2627146A1 (de) 1976-12-30
ATA440876A (de) 1977-08-15

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