CA1037806A - Intra-uterine contraceptive device - Google Patents
Intra-uterine contraceptive deviceInfo
- Publication number
- CA1037806A CA1037806A CA215,354A CA215354A CA1037806A CA 1037806 A CA1037806 A CA 1037806A CA 215354 A CA215354 A CA 215354A CA 1037806 A CA1037806 A CA 1037806A
- Authority
- CA
- Canada
- Prior art keywords
- stem
- rounded
- branches
- synthetic plastic
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003433 contraceptive agent Substances 0.000 title claims abstract description 92
- 230000002254 contraceptive effect Effects 0.000 title claims abstract description 68
- 229920003023 plastic Polymers 0.000 claims abstract description 97
- 239000004033 plastic Substances 0.000 claims abstract description 97
- 229910052751 metal Inorganic materials 0.000 claims abstract description 44
- 239000002184 metal Substances 0.000 claims abstract description 44
- -1 e.g. Substances 0.000 claims abstract description 28
- 239000000126 substance Substances 0.000 claims abstract description 25
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims abstract description 21
- 239000004698 Polyethylene Substances 0.000 claims abstract description 16
- 239000013543 active substance Substances 0.000 claims abstract description 16
- 229960004400 levonorgestrel Drugs 0.000 claims abstract description 16
- 229920000573 polyethylene Polymers 0.000 claims abstract description 16
- 150000002739 metals Chemical class 0.000 claims abstract description 12
- 229960003387 progesterone Drugs 0.000 claims abstract description 11
- 239000000186 progesterone Substances 0.000 claims abstract description 11
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005977 Ethylene Substances 0.000 claims abstract description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 49
- 239000000463 material Substances 0.000 claims description 49
- 229910052802 copper Inorganic materials 0.000 claims description 43
- 239000010949 copper Substances 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 30
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 28
- 239000004332 silver Substances 0.000 claims description 27
- 229910052709 silver Inorganic materials 0.000 claims description 26
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 25
- 229920002379 silicone rubber Polymers 0.000 claims description 25
- 239000011248 coating agent Substances 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 22
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 21
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims description 20
- 239000004945 silicone rubber Substances 0.000 claims description 17
- 229920001971 elastomer Polymers 0.000 claims description 14
- 239000000806 elastomer Substances 0.000 claims description 14
- 229910052759 nickel Inorganic materials 0.000 claims description 12
- 235000012239 silicon dioxide Nutrition 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 230000003054 hormonal effect Effects 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 claims description 9
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 238000012216 screening Methods 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 229960000978 cyproterone acetate Drugs 0.000 claims description 6
- 230000003152 gestagenic effect Effects 0.000 claims description 5
- 229940053934 norethindrone Drugs 0.000 claims description 5
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 5
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000002518 antifoaming agent Substances 0.000 claims description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 3
- 238000007334 copolymerization reaction Methods 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 229910052763 palladium Inorganic materials 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 230000000717 retained effect Effects 0.000 claims description 3
- 229910001415 sodium ion Inorganic materials 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- ZVAVDTDDBJNPJQ-UHFFFAOYSA-N ethanol;platinum Chemical compound [Pt].CCO ZVAVDTDDBJNPJQ-UHFFFAOYSA-N 0.000 claims description 2
- 229940053973 novocaine Drugs 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 229910052697 platinum Inorganic materials 0.000 claims description 2
- 150000003058 platinum compounds Chemical class 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 2
- 238000005728 strengthening Methods 0.000 claims description 2
- 229960004418 trolamine Drugs 0.000 claims description 2
- 229940072358 xylocaine Drugs 0.000 claims description 2
- 239000010410 layer Substances 0.000 claims 15
- 150000003431 steroids Chemical class 0.000 claims 5
- 238000009713 electroplating Methods 0.000 claims 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 239000012815 thermoplastic material Substances 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 239000012790 adhesive layer Substances 0.000 claims 1
- 239000003302 ferromagnetic material Substances 0.000 claims 1
- 229910001092 metal group alloy Inorganic materials 0.000 abstract description 4
- 229960003843 cyproterone Drugs 0.000 abstract description 3
- 229940088597 hormone Drugs 0.000 abstract description 3
- 239000005556 hormone Substances 0.000 abstract description 3
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 abstract description 3
- 229960001390 mestranol Drugs 0.000 abstract description 3
- 239000000872 buffer Substances 0.000 abstract description 2
- 229960005015 local anesthetics Drugs 0.000 abstract description 2
- DUSHUSLJJMDGTE-ZJPMUUANSA-N cyproterone Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DUSHUSLJJMDGTE-ZJPMUUANSA-N 0.000 abstract 1
- 229940124558 contraceptive agent Drugs 0.000 description 29
- 210000004291 uterus Anatomy 0.000 description 29
- 239000003814 drug Substances 0.000 description 24
- 230000000694 effects Effects 0.000 description 16
- 230000000704 physical effect Effects 0.000 description 16
- 229940094415 intrauterine contraceptives Drugs 0.000 description 15
- 239000002831 pharmacologic agent Substances 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 11
- 229920001169 thermoplastic Polymers 0.000 description 11
- 239000004416 thermosoftening plastic Substances 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 9
- 230000036407 pain Effects 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 208000014674 injury Diseases 0.000 description 8
- 238000000465 moulding Methods 0.000 description 8
- 230000035935 pregnancy Effects 0.000 description 8
- 230000002269 spontaneous effect Effects 0.000 description 8
- 239000003984 copper intrauterine device Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
- 239000003270 steroid hormone Substances 0.000 description 4
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 238000004070 electrodeposition Methods 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 230000035558 fertility Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000004922 lacquer Substances 0.000 description 3
- 210000003200 peritoneal cavity Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- ZTXJZSCFNCDIQL-JOOCFJGPSA-N [(8r,9s,10r,13s,14s,16r,17r)-17-acetyl-4,6-dichloro-10,13,16-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1=C(Cl)C2=C(Cl)C(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(C)=O)(OC(C)=O)[C@@]1(C)CC2 ZTXJZSCFNCDIQL-JOOCFJGPSA-N 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000007405 data analysis Methods 0.000 description 2
- 229960004913 dydrogesterone Drugs 0.000 description 2
- JGMOKGBVKVMRFX-HQZYFCCVSA-N dydrogesterone Chemical compound C1=CC2=CC(=O)CC[C@@]2(C)[C@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 JGMOKGBVKVMRFX-HQZYFCCVSA-N 0.000 description 2
- 229960003399 estrone Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229960002985 medroxyprogesterone acetate Drugs 0.000 description 2
- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 2
- 229960004296 megestrol acetate Drugs 0.000 description 2
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 2
- 229960001207 micronized progesterone Drugs 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229960003604 testosterone Drugs 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
- RSRDWHPVTMQUGZ-OZIWPBGVSA-N 1-[(8r,9s,10s,13s,14s,17s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1CC2CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RSRDWHPVTMQUGZ-OZIWPBGVSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- 229910001316 Ag alloy Inorganic materials 0.000 description 1
- 229910000881 Cu alloy Inorganic materials 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 description 1
- VXLCKSFMONBCLQ-UHFFFAOYSA-N [Na]CC[Na] Chemical group [Na]CC[Na] VXLCKSFMONBCLQ-UHFFFAOYSA-N 0.000 description 1
- DSUODLUHWINJIG-GSHVHHBMSA-N acetic acid (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one Chemical compound CC(O)=O.CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C DSUODLUHWINJIG-GSHVHHBMSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 description 1
- 229960001616 chlormadinone acetate Drugs 0.000 description 1
- 230000002920 convulsive effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000010339 dilation Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 238000005246 galvanizing Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229960001652 norethindrone acetate Drugs 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/142—Wirelike structures, e.g. loops, rings, spirals
- A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2361206A DE2361206C3 (de) | 1973-12-06 | 1973-12-06 | Intraunterines Empfängnisverhütungsmittel |
| DE2402882A DE2402882A1 (de) | 1974-01-18 | 1974-01-18 | Intrauterines empfaengnisverhuetungsmittel |
| DE19742426944 DE2426944A1 (de) | 1974-06-01 | 1974-06-01 | Intracervicales anhaengsel fuer metallhaltige intrauterine empfaengnisverhuetungsmittel und empfaengnisverhuetungsmittel mit anhaengsel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1037806A true CA1037806A (en) | 1978-09-05 |
Family
ID=27185663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA215,354A Expired CA1037806A (en) | 1973-12-06 | 1974-12-06 | Intra-uterine contraceptive device |
Country Status (20)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4155991A (en) * | 1974-10-18 | 1979-05-22 | Schering Aktiengesellschaft | Vaginal ring |
| FR2390967A1 (fr) * | 1977-05-16 | 1978-12-15 | Akiyama Hiroshi | Catheter |
| CS232807B1 (en) * | 1982-05-04 | 1985-02-14 | Valter Jakubek | Inter-uterus anticonception little body and method of its making |
| NZ200564A (en) * | 1982-05-10 | 1987-03-06 | Ahi Operations Ltd | Device for slowly releasing chemicals into body cavities of animals |
| DE3367159D1 (en) * | 1983-01-20 | 1986-12-04 | Cimber Hugo | Occlusive pessary |
| EP0147274A1 (fr) * | 1983-12-01 | 1985-07-03 | BIOMASYS Société dite: | Perfectionnements apportés aux dispositifs intra-utérins |
| FR2565482A2 (fr) * | 1984-06-07 | 1985-12-13 | Biomasys | Perfectionnements apportes aux dispositifs intra-uterins |
| FR2555893A1 (fr) * | 1983-12-01 | 1985-06-07 | Biomasys | Perfectionnements apportes aux dispositifs intra-uterins |
| BE901652A (fr) * | 1985-02-05 | 1985-05-29 | Wildemeersch Dirk | Dispositif anticonceptionnel intra-uterin nouveau et perfectionne, et son dispositif d'insertion et de fixation a la matrice. |
| JPS6243335U (enrdf_load_stackoverflow) * | 1985-09-02 | 1987-03-16 | ||
| HU200554B (en) * | 1987-06-01 | 1990-07-28 | Kalman Patai | Intra-uterine contraceptive device |
| DE19542386A1 (de) * | 1995-11-01 | 1997-05-15 | Hamann Bernd Dr Med Habil | Intrauterines Pessar |
| US6759393B1 (en) | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
| MXPA03009458A (es) * | 2003-10-16 | 2005-04-21 | Guillermo Sanders Acedo | Metodo para la fabricacion y colocacion de un dispositivo intrauterino adaptado a las medidas de la cavidad uterina. |
| EP1902693A1 (en) * | 2006-09-20 | 2008-03-26 | Melinda-Kinga Karpati | Intrauterine contraceptive device |
| EP2770959A1 (en) * | 2011-10-28 | 2014-09-03 | Sujoy Kumar Guha | An improved intra-uterine contraceptive device |
| HUE049219T2 (hu) | 2013-02-08 | 2020-09-28 | Qpharma Ab | Intravaginális eszköz, valamint eljárás az intravaginális eszközben lévõ hatóanyag diffúziós sebességének csökkentésére |
| EP2982352B1 (en) * | 2014-06-28 | 2018-10-03 | Laboratorios Andrómaco S.A. | Cervical pessary containing progesterone for prolonged, sustained and continuous release, used to prevent premature birth |
| SI24779A (sl) * | 2014-08-28 | 2016-02-29 | CABALLUS CARNIOLUS & AMSTERDAMUS, veterinarsko tehnološki center in trgovina, uvoz - izvoz d.o.o. | Vstavek za ljudi in živali ter postopek izdelave le-tega |
| JP6895455B2 (ja) * | 2016-01-04 | 2021-06-30 | ジュロックス ピーティーワイ リミテッドＪｕｒｏｘ Ｐｔｙ Ｌｔｄ | 薬剤放出デバイス及び使用 |
| CN106726093A (zh) * | 2016-12-27 | 2017-05-31 | 江苏省计划生育科学技术研究所 | 一种节育器及医用避孕器械 |
| JP2019171193A (ja) * | 2019-07-17 | 2019-10-10 | オコン メディカル リミテッド | 子宮腔に配置可能な器具 |
-
1974
- 1974-12-04 DD DD182776A patent/DD114905A5/xx unknown
- 1974-12-04 EG EG533/74A patent/EG11114A/xx active
- 1974-12-05 PH PH16596A patent/PH15580A/en unknown
- 1974-12-05 IE IE2505/74A patent/IE42319B1/en unknown
- 1974-12-05 SE SE7415258-8A patent/SE413284B/xx unknown
- 1974-12-05 YU YU03222/74A patent/YU322274A/xx unknown
- 1974-12-05 HU HU74SCHE502A patent/HU178750B/hu unknown
- 1974-12-05 FI FI3523/74A patent/FI58053C/fi active
- 1974-12-05 CH CH1616674A patent/CH604686A5/xx not_active IP Right Cessation
- 1974-12-05 NO NO744398A patent/NO139429C/no unknown
- 1974-12-06 DK DK636974A patent/DK137625C/da not_active IP Right Cessation
- 1974-12-06 ES ES432678A patent/ES432678A1/es not_active Expired
- 1974-12-06 JP JP49140380A patent/JPS5749218B2/ja not_active Expired
- 1974-12-06 GB GB52961/74A patent/GB1495735A/en not_active Expired
- 1974-12-06 IL IL46196A patent/IL46196A/xx unknown
- 1974-12-06 NL NL7415908A patent/NL7415908A/xx not_active Application Discontinuation
- 1974-12-06 CA CA215,354A patent/CA1037806A/en not_active Expired
- 1974-12-06 IT IT30289/74A patent/IT1049334B/it active
- 1974-12-06 FR FR7440077A patent/FR2253537B1/fr not_active Expired
- 1974-12-06 PL PL1974176239A patent/PL100167B1/pl unknown
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