CA1024139A - 1,3-oxazino(5,6-c)-rifamycins and method for preparing the same - Google Patents

1,3-oxazino(5,6-c)-rifamycins and method for preparing the same

Info

Publication number
CA1024139A
CA1024139A CA200,755A CA200755A CA1024139A CA 1024139 A CA1024139 A CA 1024139A CA 200755 A CA200755 A CA 200755A CA 1024139 A CA1024139 A CA 1024139A
Authority
CA
Canada
Prior art keywords
oxazino
rifamycins
preparing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA200,755A
Other languages
English (en)
French (fr)
Inventor
Leonardo Marsili
Carmine Pasqualucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA
Original Assignee
ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT2706673A external-priority patent/IT1043857B/it
Priority claimed from IT1977474A external-priority patent/IT1054154B/it
Application filed by ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA filed Critical ARCHIFAR INDUSTRIE CHIMICHE DEL TRENTINO SpA
Application granted granted Critical
Publication of CA1024139A publication Critical patent/CA1024139A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA200,755A 1973-07-25 1974-05-24 1,3-oxazino(5,6-c)-rifamycins and method for preparing the same Expired CA1024139A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2706673A IT1043857B (it) 1973-07-25 1973-07-25 Derivati delle rifapicime procedimento della loro sintesi e loro impiego quali intermeni per la produzione di sofamicine
IT1977474A IT1054154B (it) 1974-01-24 1974-01-24 Procedimento per la preparazione di ossazino rifamione

Publications (1)

Publication Number Publication Date
CA1024139A true CA1024139A (en) 1978-01-10

Family

ID=26327298

Family Applications (2)

Application Number Title Priority Date Filing Date
CA200,755A Expired CA1024139A (en) 1973-07-25 1974-05-24 1,3-oxazino(5,6-c)-rifamycins and method for preparing the same
CA201,355A Expired CA1022548A (en) 1973-07-25 1974-05-31 Process for the preparation of 3-iminomethyl derivatives of rifamycin sv

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA201,355A Expired CA1022548A (en) 1973-07-25 1974-05-31 Process for the preparation of 3-iminomethyl derivatives of rifamycin sv

Country Status (25)

Country Link
US (3) US3963705A (xx)
JP (2) JPS5339440B2 (xx)
AR (2) AR207762A1 (xx)
AT (2) AT334530B (xx)
BE (2) BE815122A (xx)
CA (2) CA1024139A (xx)
CH (2) CH615683A5 (xx)
DD (2) DD112133A5 (xx)
DE (2) DE2428387A1 (xx)
DK (2) DK284874A (xx)
ES (2) ES429060A1 (xx)
FI (2) FI153574A (xx)
FR (2) FR2257297B1 (xx)
GB (2) GB1454801A (xx)
HU (2) HU167983B (xx)
IE (2) IE39388B1 (xx)
IN (2) IN138735B (xx)
NL (2) NL7409892A (xx)
NO (2) NO142305C (xx)
PH (1) PH13691A (xx)
PL (1) PL91647B1 (xx)
RO (1) RO63865A (xx)
SE (2) SE393112B (xx)
SU (2) SU613725A3 (xx)
YU (2) YU36720B (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207762A1 (es) * 1973-07-25 1976-10-29 Archifar Ind Chim Trentino Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina
GB1576886A (en) * 1977-04-20 1980-10-15 Lepetit Spa Rifamycin derivatives
US4179439A (en) * 1977-07-01 1979-12-18 Intreprinderea De Antibiotice Iasi Rifamycins and method for their preparation
JPS5473798A (en) * 1977-11-15 1979-06-13 Kanebo Ltd Novel 1,3-oxazino (5,6-c) rifamycin derivative
JPS5473799A (en) * 1977-11-16 1979-06-13 Kanebo Ltd Preparation of 1,3-oxazino (5,6-c) rifamycin derivative
GB1594134A (en) * 1977-11-25 1981-07-30 Holco Investment Inc Rifamycins
JPS5484600A (en) * 1977-12-15 1979-07-05 Kanebo Ltd Preparation of 1,3-oxazino 5,6-c rifamycin derivative
JPS5776597A (en) * 1980-10-30 1982-05-13 Kiyouritsu Kurieiteibu Asoshie Electric musical instrument
JPS58115705U (ja) * 1982-02-01 1983-08-08 株式会社ニコン カメラのフアインダ光学系
GB8308166D0 (en) * 1983-03-24 1983-05-05 Erba Farmitalia Preparation of azinomethyl-rifamycins
GB8318072D0 (en) * 1983-07-04 1983-08-03 Lepetit Spa Water-soluble rifampicin derivatives
DE69735383T2 (de) * 1996-11-19 2007-02-15 Georgetown University Methode zur Inhibierung von HEREGULIN und seines Rezeptors sowie Verwendung zur Inhibierung von Krebszellen
US20090275594A1 (en) * 2008-05-05 2009-11-05 Macielag Mark J 3-hydrazone piperazinyl rifamycin derivatives useful as antimicrobial agents
CN103755723B (zh) * 2014-02-07 2016-04-20 天津大学 一种利福平i晶型的制备方法
CN103951677B (zh) * 2014-03-17 2016-04-06 四川省长征药业股份有限公司 利福喷丁的制备方法
CN106632394A (zh) * 2016-11-15 2017-05-10 南京工业大学 一种利用釜式反应装置与微通道反应装置串联反应制备利福平的方法
CN106749326A (zh) * 2016-11-28 2017-05-31 南京工业大学 一种由利福霉素s钠盐连续生产制备利福平的方法
CN111848639A (zh) * 2020-07-09 2020-10-30 华东理工大学 一种合成利福平的工艺方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090115A (en) * 1964-04-02 1967-11-08 Lepetit Spa Mannich bases of rifamycin sv
FR208F (xx) * 1964-07-31
DE1795568C3 (de) * 1964-07-31 1974-07-18 Gruppo Lepetit S.P.A., Mailand (Italien) 3-Hydroxymethyl-rifamycin SV und Verfahren zu seiner Herstellung. Ausscheidung aus: 1595883
US3542762A (en) * 1967-06-07 1970-11-24 Lepetit Spa Process for rifamycins
AR207762A1 (es) * 1973-07-25 1976-10-29 Archifar Ind Chim Trentino Procedimiento para la preparacion de 3-((4-metil-1-piperazin-1-il)-imino)-metil-rifamicina sv o rifampicina

Also Published As

Publication number Publication date
NO741764L (xx) 1975-02-24
DD112267A5 (xx) 1975-04-05
FI153574A (xx) 1975-01-26
FI60397C (fi) 1982-01-11
BE817823A (fr) 1974-11-18
NO142305C (no) 1980-07-30
FR2245631B1 (xx) 1978-09-15
AT334530B (de) 1976-01-25
GB1454802A (en) 1976-11-03
ATA496174A (de) 1976-05-15
AU6990574A (en) 1975-12-11
DK135286B (da) 1977-03-28
CH611296A5 (xx) 1979-05-31
USRE31587E (en) 1984-05-22
YU36719B (en) 1984-08-31
DK284774A (xx) 1975-01-26
US3925366A (en) 1975-12-09
IE39389B1 (en) 1978-09-27
FR2257297B1 (xx) 1978-07-21
SE7406073L (xx) 1975-01-27
SU576943A3 (ru) 1977-10-15
IN138735B (xx) 1976-03-27
SE7406074L (xx) 1975-01-27
YU132574A (en) 1981-11-13
SE393112B (sv) 1977-05-02
DE2433105A1 (de) 1975-02-06
SU613725A3 (ru) 1978-06-30
NL181992B (nl) 1987-07-16
AU6991074A (en) 1975-12-11
HU168723B (xx) 1976-07-28
AR207762A1 (es) 1976-10-29
DK284874A (da) 1975-01-26
DE2428387A1 (de) 1975-02-13
PL91647B1 (xx) 1977-03-31
HU167983B (xx) 1976-02-28
NO142305B (no) 1980-04-21
NL181992C (nl) 1987-12-16
YU132474A (en) 1981-11-13
NL7409955A (nl) 1975-01-28
JPS5314080B2 (xx) 1978-05-15
ES429059A1 (es) 1976-08-16
YU36720B (en) 1984-08-31
NL7409892A (nl) 1975-01-28
JPS5041897A (xx) 1975-04-16
RO63865A (fr) 1979-01-15
CH615683A5 (xx) 1980-02-15
AR207763A1 (es) 1976-10-29
CA1022548A (en) 1977-12-13
BE815122A (fr) 1974-09-16
JPS5339440B2 (xx) 1978-10-21
IE39388B1 (en) 1978-09-27
FI60397B (fi) 1981-09-30
JPS5042021A (xx) 1975-04-16
IE39388L (en) 1975-01-25
SE407803B (sv) 1979-04-23
IN139074B (xx) 1976-05-01
FI157574A (xx) 1975-01-26
NO741763L (xx) 1975-02-24
FR2257297A1 (xx) 1975-08-08
US3963705A (en) 1976-06-15
PH13691A (en) 1980-09-01
GB1454801A (en) 1976-11-03
IE39389L (en) 1975-01-25
FR2245631A1 (xx) 1975-04-25
DD112133A5 (xx) 1975-03-20
DK135286C (xx) 1977-09-05
DE2433105C2 (xx) 1988-03-31
SU613725A1 (xx) 1978-06-30
ES429060A1 (es) 1976-08-16
AT334531B (de) 1976-01-25
ATA596774A (de) 1976-05-15

Similar Documents

Publication Publication Date Title
CA1024139A (en) 1,3-oxazino(5,6-c)-rifamycins and method for preparing the same
CA1033750A (en) 5-methyl-isoflavone-derivatives, process for the preparation thereof and compositions containing the same
CA1027589A (en) 2,7,10,15,18,23-hexamethyltetracosane and process for preparing the same
CA1022191A (en) Process for preparing 2,6-dimethylnaphthalenes
CA1027951A (en) Process for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine
CA1027950A (en) Process for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine
CA1019334A (en) Process for preparing 2,4-dimethyl-3-carboxanilido-or carboxanaphthylamido-furan
CA1032938A (en) Pyrido (1,2a)-pyrimidine-derivatives and process for the preparation thereof
AU477010B2 (en) 1,3-oxygenated &-oestratrienes
CA1027952A (en) Process for the preparation of 2,2,6,6-tetramethyl-4-oxopiperidine
CA1030541A (en) Process for preparing 4,5-diphenyl-oxazol-2-one
AU497120B2 (en) Polyhydroxy-alkyl-3,5-disubstituted-2, 4,6-triiodo-carbanilates
CA1003418A (en) 1,3-BIS(.beta.-ETHYLHEXYL)-5-AMINO-5-METHYLHEXAHYDROPYRIMIDINE-PYRIDINE-3-CARBOXYLATE AND PROCESS FOR THE PREPARATION THEREOF
AU498671B2 (en) 1-aryl-2-oxo-hexahydro-2,4,5,6,7,7a-indoles
CA1024140A (en) 6-anilino-1,4,5-trihydroxyanthraquinones
CA998346A (en) Method for preparing 3(s or r)-hydroxy-1-iodo-1-trans-octene
CA1021776A (en) 7,8-dihydroisomorphine derivatives and a process for the preparation thereof
CA1016173A (en) 1,4-dihydro-2-h-isoquinoline derivatives and process for their manufacture
AU503626B2 (en) Substituted 1, 5-diphenyl-3-formazancarbonitriles
CA1021331A (en) 9,12-bridged ethenoanthracenes and compounds derived therefrom
CA1018157A (en) 8,8'-dioxo-6,6'-azopurine
AU479260B2 (en) 1, 3-OXAZINO (5, 6-c) RIFAMYCINS AND METHOD FOR PREPARING SAME
ZA742925B (en) 1,3-oxazino(5,6-c)rifamycins and method for preparing the same
CA1015744A (en) 15.alpha. - SULFONYLOXY - 12.beta. - HYDROXYPREGNANES AND PROCESS FOR THE PREPARATION THEREOF
CA1032163A (en) 1,2-dihydrophthalazine-1-acetic acids