CA1014947A - Steroids of the pregnane series having anaesthetic activity - Google Patents

Steroids of the pregnane series having anaesthetic activity

Info

Publication number
CA1014947A
CA1014947A CA171,026A CA171026A CA1014947A CA 1014947 A CA1014947 A CA 1014947A CA 171026 A CA171026 A CA 171026A CA 1014947 A CA1014947 A CA 1014947A
Authority
CA
Canada
Prior art keywords
steroids
pregnane series
anaesthetic activity
anaesthetic
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA171,026A
Other languages
English (en)
Other versions
CA171026S (en
Inventor
Barry E. Ayres
Leslie Stephenson
Robin Lawrence
Gordon H. Phillipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Application granted granted Critical
Publication of CA1014947A publication Critical patent/CA1014947A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA171,026A 1972-05-12 1973-05-11 Steroids of the pregnane series having anaesthetic activity Expired CA1014947A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2248972A GB1436324A (en) 1972-05-12 1972-05-12 Anaesthetic 3alpha-hydroxy pregnanes

Publications (1)

Publication Number Publication Date
CA1014947A true CA1014947A (en) 1977-08-02

Family

ID=10180241

Family Applications (1)

Application Number Title Priority Date Filing Date
CA171,026A Expired CA1014947A (en) 1972-05-12 1973-05-11 Steroids of the pregnane series having anaesthetic activity

Country Status (13)

Country Link
US (1) US3998829A (en, 2012)
JP (1) JPS4948652A (en, 2012)
AU (1) AU474687B2 (en, 2012)
BE (1) BE799433A (en, 2012)
CA (1) CA1014947A (en, 2012)
DE (1) DE2323950A1 (en, 2012)
DK (1) DK135775B (en, 2012)
FR (1) FR2184711B1 (en, 2012)
GB (1) GB1436324A (en, 2012)
IE (1) IE38863B1 (en, 2012)
LU (1) LU67585A1 (en, 2012)
NL (1) NL7306606A (en, 2012)
ZA (1) ZA733218B (en, 2012)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613463A (en) * 1984-11-01 1986-09-23 The Upjohn Company Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
USRE35053E (en) * 1985-09-12 1995-10-10 The Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5099019A (en) * 1985-09-12 1992-03-24 Upjohn Company Amines useful in producing pharmaceutically active CNS compounds
US5380840A (en) * 1985-09-12 1995-01-10 The Upjohn Company Triazinylpiperazinyl steroids
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
JPH072555Y2 (ja) * 1991-06-03 1995-01-25 日野自動車工業株式会社 車輛の前後方向兼用ウインチ
US6780853B1 (en) 1995-06-06 2004-08-24 Euro-Celtique S.A. Neuroactive steroids of the androstane and pregnane series
BR9608592A (pt) * 1995-06-06 1999-06-29 Cocensys Inc Esteróides neuroativos da série do androstano e do pregnano
US6143737A (en) * 1995-06-23 2000-11-07 Georgetown University Progesterone analogs to reverse multidrug resistance
HUP0201818A3 (en) * 1999-04-29 2004-04-28 Euro Celtique Sa 3alpha-hydroxy-3beta-methoxymethyl-21-heterocycle substituted steroids with anesthetic activity and pharmaceutical compositions containing the same
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
EP3572417A3 (en) 2011-10-14 2020-03-25 Sage Therapeutics, Inc. 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
US9365611B2 (en) 2013-04-17 2016-06-14 Sage Therapeutics, Inc. 19-NOR neuroactive steroids and methods of use thereof
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
HRP20190232T1 (hr) 2013-04-17 2019-03-22 Sage Therapeutics, Inc. 19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
HRP20210610T1 (hr) 2013-07-19 2021-05-28 Sage Therapeutics, Inc. Neuroaktivni steroidi, pripravci i njihove uporabe
EP3831387A1 (en) 2013-08-23 2021-06-09 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US20170233433A1 (en) 2014-10-16 2017-08-17 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
PH12017500711B1 (en) 2014-10-16 2022-12-09 Sage Therapeutics Inc Compositions and methods for treating cns disorders
EP3719029A1 (en) 2014-11-27 2020-10-07 Sage Therapeutics, Inc. Compositions for inducing sedation
PT3250210T (pt) 2015-01-26 2021-03-26 Sage Therapeutics Inc Composições e métodos para o tratamento de distúrbios do snc
WO2016134301A2 (en) 2015-02-20 2016-08-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
AU2017296295B2 (en) 2016-07-11 2022-02-24 Sage Therapeutics, Inc. C7, C12, and C16 substituted neuroactive steroids and their methods of use
EP3481845B1 (en) 2016-07-11 2023-09-13 Sage Therapeutics, Inc. C17, c20, and c21 substituted neuroactive steroids and their methods of use
EP3976628A1 (en) 2019-05-31 2022-04-06 Sage Therapeutics, Inc. Neuroactive steroids and compositions thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1107662B (de) * 1959-07-04 1961-05-31 Merck Ag E Verfahren zur Herstellung von Mannichbasen von Steroiden bzw. von deren Saeureadditionssalzen
US3042691A (en) * 1960-05-11 1962-07-03 Pfizer & Co C 5alpha,21-dibromo-6beta-fluoro-21-methyl-pregnanes and process for making same
FR1764M (fr) * 1962-02-20 1963-04-08 Roussel Uclaf Nouveau médicament notamment pour le traitement des spasmes d'origine coronarienne ou viscérale.
US3201425A (en) * 1963-12-10 1965-08-17 American Cyanamid Co 20-alkoxy-delta20-21-carboxaldehydes of the pregnane series and method of preparing the same
GB1089945A (en) * 1965-09-23 1967-11-08 British Drug Houses Ltd Steroidal-6-spirocyclopropyl-4-en-3-ones
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
DE1941226A1 (de) * 1969-08-13 1971-02-18 Degussa Basisch substituierte Ketosteroide
US3661940A (en) * 1970-04-13 1972-05-09 Sandoz Ag Derivatives of 21-methyl-19-norpregnanes
GB1377609A (en) * 1970-12-17 1974-12-18 Glaxo Lab Ltd 3alpha-hydroxy-5alpha-pregnane compounds
GB1416427A (en) * 1972-01-12 1975-12-03 Akzo Nv Alkylated pregnanes and process for obtaining same

Also Published As

Publication number Publication date
ZA733218B (en) 1974-05-29
GB1436324A (en) 1976-05-19
NL7306606A (en, 2012) 1973-11-14
FR2184711A1 (en, 2012) 1973-12-28
LU67585A1 (en, 2012) 1973-07-24
DK135775B (da) 1977-06-20
DK135775C (en, 2012) 1977-11-21
AU474687B2 (en) 1976-07-29
IE38863B1 (en) 1978-06-21
US3998829A (en) 1976-12-21
AU5561673A (en) 1974-11-14
JPS4948652A (en, 2012) 1974-05-11
BE799433A (fr) 1973-11-12
DE2323950A1 (de) 1973-12-13
FR2184711B1 (en, 2012) 1977-01-07
IE38863L (en) 1973-11-12

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