BRPI9912227B1 - método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. - Google Patents
método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método.Info
- Publication number
- BRPI9912227B1 BRPI9912227B1 BRPI9912227-8B1A BRPI9912227A BRPI9912227B1 BR PI9912227 B1 BRPI9912227 B1 BR PI9912227B1 BR PI9912227 A BRPI9912227 A BR PI9912227A BR PI9912227 B1 BRPI9912227 B1 BR PI9912227B1
- Authority
- BR
- Brazil
- Prior art keywords
- early
- carcinomas
- kit
- carrying
- vitro diagnosis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 201000009030 Carcinoma Diseases 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 101710150974 Regulator of chromosome condensation Proteins 0.000 abstract 1
- 102100039977 Regulator of chromosome condensation Human genes 0.000 abstract 1
- 238000013399 early diagnosis Methods 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19829473A DE19829473C2 (de) | 1998-07-01 | 1998-07-01 | Verfahren zur frühen Diagnose von Carcinomen |
| PCT/DE1999/002094 WO2000001845A2 (de) | 1998-07-01 | 1999-07-01 | Verfahren zur frühen diagnose von carcinomen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI9912227A BRPI9912227A (pt) | 2001-04-24 |
| BRPI9912227B1 true BRPI9912227B1 (pt) | 2013-08-20 |
| BRPI9912227B8 BRPI9912227B8 (pt) | 2021-07-06 |
Family
ID=7872684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9912227-8B1 BRPI9912227B8 (pt) | 1998-07-01 | 1999-07-01 | método para diagnóstico precoce in vitro de carcinomas e de seus estágios iniciais e kit para realização do método. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6709832B1 (pt) |
| EP (1) | EP1092155B1 (pt) |
| JP (1) | JP3404020B2 (pt) |
| KR (1) | KR100646193B1 (pt) |
| CN (1) | CN1209627C (pt) |
| AT (1) | ATE230487T1 (pt) |
| AU (1) | AU749769B2 (pt) |
| BR (1) | BRPI9912227B8 (pt) |
| CA (1) | CA2336153C (pt) |
| CZ (1) | CZ292076B6 (pt) |
| DE (2) | DE19829473C2 (pt) |
| DK (1) | DK1092155T3 (pt) |
| ES (1) | ES2190820T3 (pt) |
| HK (1) | HK1038609A1 (pt) |
| HU (1) | HUP0102744A2 (pt) |
| IL (1) | IL140550A (pt) |
| MX (1) | MXPA00012852A (pt) |
| NO (1) | NO328685B1 (pt) |
| PL (1) | PL198623B1 (pt) |
| RU (1) | RU2217761C2 (pt) |
| SK (1) | SK284056B6 (pt) |
| TR (1) | TR200003903T2 (pt) |
| WO (1) | WO2000001845A2 (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7306926B2 (en) * | 1998-07-01 | 2007-12-11 | Mtm Laboratories Ag | Method for detecting carcinomas in a solubilized cervical body sample |
| AUPP991199A0 (en) * | 1999-04-21 | 1999-05-13 | University Of Sydney, The | Methods for diagnosing pre-cancerous and cancerous conditions |
| DE10006033B4 (de) | 2000-02-10 | 2005-11-10 | Professor Dr. Magnus von Knebel Doeberitz Chirurgische Universitätsklinik Sektion für Molekulare Diagnostik und Therapie | Immunisierung eines Individuums gegen Carcinome und ihre Vorstufen |
| US20060057651A1 (en) * | 2000-12-08 | 2006-03-16 | Bowdish Katherine S | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US7408041B2 (en) | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US9249229B2 (en) | 2000-12-08 | 2016-02-02 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| AUPR201500A0 (en) * | 2000-12-11 | 2001-01-11 | Biosceptre Pty Ltd | Methods for identifying pre-neoplastic and neoplastic states in mammals |
| DE10063179A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern |
| DE60230482D1 (de) | 2001-01-17 | 2009-02-05 | Intreat Pty Ltd | Antikörper gegen nichtfunktionelle p 2 x 7 rezeptoren, diagnose und behandlung von krebs und anderen leiden |
| EP1369694A1 (en) | 2002-04-09 | 2003-12-10 | MTM Laboratories AG | Method for discrimination of metaplasias from neoplastic or preneoplastic lesions |
| ATE261126T1 (de) * | 2002-08-01 | 2004-03-15 | Mtm Lab Ag | Verfahren für lösung-basierte diagnose |
| EP1422526A1 (en) * | 2002-10-28 | 2004-05-26 | MTM Laboratories AG | Method for improved diagnosis of dysplasias |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| DE602004025676D1 (de) * | 2003-02-26 | 2010-04-08 | Sysmex Corp | Verfahren zur untersuchung einer zelle |
| DE60300339T2 (de) * | 2003-08-25 | 2006-04-13 | Mtm Laboratories Ag | Verfahren zum Nachweis von Karzinomen in solubilisierten zervikalen Körperproben |
| KR20110027823A (ko) * | 2004-03-24 | 2011-03-16 | 트리패스 이미징, 인코포레이티드 | 자궁경부 질환의 검사 방법 및 조성물 |
| US8921057B2 (en) * | 2004-05-31 | 2014-12-30 | Sysmex Corporation | Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same |
| EP1628135A1 (en) * | 2004-08-20 | 2006-02-22 | MTM Laboratories AG | Method for detecting medically relevant conditions in a solubilized LBC sample |
| US7892750B1 (en) * | 2004-12-23 | 2011-02-22 | University Of Notre Dame Du Lac | Cathepsin E as a marker of colon cancer |
| JP4766969B2 (ja) | 2005-09-14 | 2011-09-07 | シスメックス株式会社 | 組織性質判定装置 |
| US7972776B2 (en) * | 2005-11-15 | 2011-07-05 | Oncohealth Corporation | Protein chips for HPV detection |
| EP3101033B1 (en) | 2006-01-12 | 2019-01-02 | Alexion Pharmaceuticals, Inc. | Antibodies to ox-2/cd200 and uses thereof |
| JP2010505426A (ja) * | 2006-10-10 | 2010-02-25 | バイオスセプター インターナショナル リミテッド | 非機能性ｐ２ｘ７受容体に対する抗体を産生するハイブリドーマ |
| US8278056B2 (en) * | 2008-06-13 | 2012-10-02 | Oncohealth Corp. | Detection of early stages and late stages HPV infection |
| WO2010129821A1 (en) * | 2009-05-07 | 2010-11-11 | Oncohealth Corporation | Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers |
| US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
| JP5111902B2 (ja) * | 2007-03-14 | 2013-01-09 | シスメックス株式会社 | 癌の診断支援装置 |
| US8921114B2 (en) | 2007-08-24 | 2014-12-30 | Sysmex Corporation | Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product |
| WO2009033234A1 (en) | 2007-09-14 | 2009-03-19 | Biosceptre International Limited | Purinergic (p2x) receptors in extra-cellular body fluid |
| NZ583894A (en) | 2007-09-14 | 2013-01-25 | Biosceptre Int Ltd | Antibodies that bind to a non atp binding p2x7 receptor |
| EP2318438B1 (en) | 2008-07-04 | 2016-11-02 | Biosceptre (Aust) Pty Ltd | Anti-p2x7 peptiden und epitopen |
| ES2904911T3 (es) | 2009-08-20 | 2022-04-06 | Biosceptre Aust Pty Ltd | Anticuerpos anti-receptor P2X7 y fragmentos de los mismos |
| AU2010336032C1 (en) | 2009-12-24 | 2016-04-21 | Biosceptre International Limited | Antibodies to non-functional oligomeric P2X7 receptors |
| US9128094B2 (en) | 2010-01-08 | 2015-09-08 | Oncohealth Corp. | High throughput cell-based HPV immunoassays for diagnosis and screening of HPV-associated cancers |
| US8900813B2 (en) | 2010-08-17 | 2014-12-02 | Medical Diagnostic Laboratories, Llc | CIP2A as a biomarker in detection of cervical cancer |
| EP2613808B1 (en) | 2010-09-10 | 2017-11-08 | Biosceptre (Aust) Pty Ltd | Companion animal cancer treatments with an anti p2x7 antibody |
| US9551700B2 (en) | 2010-12-20 | 2017-01-24 | Milagen, Inc. | Device and methods for the detection of cervical disease |
| US9566318B2 (en) | 2011-07-01 | 2017-02-14 | Biosceptre (Aust) Pty Ltd | Combination therapy |
| US10527526B2 (en) | 2011-11-03 | 2020-01-07 | Tripath Imaging, Inc. | Methods and compositions for preparing samples for immunostaining |
| AU2012340441A1 (en) | 2011-11-15 | 2014-05-29 | University Of Miami | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
| US11761963B2 (en) | 2017-09-27 | 2023-09-19 | Alexion Pharmaceuticals, Inc. | Biomarker signature for predicting tumor response to anti-CD200 therapy |
| WO2019234176A1 (en) | 2018-06-07 | 2019-12-12 | Universitaet Des Saarlandes | Novel biomarkers for carcinoma diagnosis |
| CN108893534A (zh) * | 2018-06-26 | 2018-11-27 | 华中科技大学鄂州工业技术研究院 | 泛癌症诊断标记物 |
| RU2707884C1 (ru) * | 2018-10-03 | 2019-12-02 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ ранней диагностики почечно-клеточной карциномы по наличию антител к зрительному аррестину |
| FR3088640A1 (fr) | 2018-10-14 | 2020-05-22 | Smart Diagnostix Pharma | Nouveau polypeptide se liant specifiquement a la proteine p16 |
| CN111257565A (zh) * | 2018-12-03 | 2020-06-09 | 上海细胞治疗集团有限公司 | 一种衰老细胞的检测试剂盒及其检测方法 |
| CN113295683A (zh) * | 2021-05-24 | 2021-08-24 | 烟台海关技术中心 | 过氧化苯甲酰检测方法 |
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| US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
| US5268463A (en) * | 1986-11-11 | 1993-12-07 | Jefferson Richard A | Plant promoter α-glucuronidase gene construct |
| JP3485186B2 (ja) | 1992-10-16 | 2004-01-13 | コールド・スプリング・ハーバー・ラボラトリー | サイクリン複合体の転位およびそれに関連する使用 |
| WO1994012881A2 (en) * | 1992-12-02 | 1994-06-09 | Hochstrasser Denis F | A METHOD FOR DETECTING GROWING CELLS USING TRANSLATIONALLY CONTROLLED TUMOR PROTEIN p21 |
| US5543291A (en) * | 1993-01-29 | 1996-08-06 | Dana Farber Cancer Institute | Method of detecting carcinoma |
| US6316208B1 (en) * | 1994-01-07 | 2001-11-13 | Memorial Sloan-Kettering Cancer Center | Methods for determining isolated p27 protein levels and uses thereof |
| JPH08510391A (ja) * | 1994-03-18 | 1996-11-05 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | Ｍｔｓ遺伝子における生殖系統の変異およびｍｔｓ遺伝子における癌の素因の検出方法 |
| US5763190A (en) * | 1994-09-21 | 1998-06-09 | The Trustees Of The University Of Pennsylvania | Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein |
| US6033847A (en) * | 1995-02-06 | 2000-03-07 | St. Jude Children's Research Hospital | InK4c-p18 and InK4d-p19, inhibitors of cyclin-dependent kinases CDK4 and CDK6, and uses thereof |
| US5976799A (en) | 1996-03-21 | 1999-11-02 | The Board Of Trustees Of The University Of Arkansas | Early detection of ovarian carcinoma using P16 gene products |
| US5851797A (en) * | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
| US5858683A (en) * | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| WO2000024245A1 (en) * | 1998-10-28 | 2000-05-04 | President And Fellows Of Harvard College | REGULATION OF TH2 CELL ACTIVITY BY MODULATION OF NFATp AND NFAT4 ACTIVITY |
-
1998
- 1998-07-01 DE DE19829473A patent/DE19829473C2/de not_active Expired - Lifetime
-
1999
- 1999-07-01 IL IL14055099A patent/IL140550A/xx not_active IP Right Cessation
- 1999-07-01 DE DE59903915T patent/DE59903915D1/de not_active Expired - Lifetime
- 1999-07-01 AT AT99945931T patent/ATE230487T1/de active
- 1999-07-01 DK DK99945931T patent/DK1092155T3/da active
- 1999-07-01 TR TR2000/03903T patent/TR200003903T2/xx unknown
- 1999-07-01 RU RU2001102598/15A patent/RU2217761C2/ru active
- 1999-07-01 CA CA002336153A patent/CA2336153C/en not_active Expired - Lifetime
- 1999-07-01 SK SK2031-2000A patent/SK284056B6/sk not_active IP Right Cessation
- 1999-07-01 ES ES99945931T patent/ES2190820T3/es not_active Expired - Lifetime
- 1999-07-01 AU AU58487/99A patent/AU749769B2/en not_active Expired
- 1999-07-01 KR KR1020017000026A patent/KR100646193B1/ko not_active IP Right Cessation
- 1999-07-01 WO PCT/DE1999/002094 patent/WO2000001845A2/de active IP Right Grant
- 1999-07-01 US US09/743,103 patent/US6709832B1/en not_active Expired - Lifetime
- 1999-07-01 CN CNB998079111A patent/CN1209627C/zh not_active Expired - Lifetime
- 1999-07-01 PL PL345407A patent/PL198623B1/pl unknown
- 1999-07-01 BR BRPI9912227-8B1 patent/BRPI9912227B8/pt not_active IP Right Cessation
- 1999-07-01 JP JP2000558235A patent/JP3404020B2/ja not_active Expired - Lifetime
- 1999-07-01 MX MXPA00012852A patent/MXPA00012852A/es active IP Right Grant
- 1999-07-01 CZ CZ20004922A patent/CZ292076B6/cs not_active IP Right Cessation
- 1999-07-01 HU HU0102744A patent/HUP0102744A2/hu unknown
- 1999-07-01 EP EP99945931A patent/EP1092155B1/de not_active Expired - Lifetime
-
2000
- 2000-12-28 NO NO20006681A patent/NO328685B1/no not_active IP Right Cessation
-
2001
- 2001-10-18 HK HK01107321A patent/HK1038609A1/xx not_active IP Right Cessation
-
2003
- 2003-02-20 US US10/371,883 patent/US20030152993A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/08/2013, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/07/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 01/07/2019 |