BRPI9800956B8 - composição terapêutica que age por inibição das serinas proteases - Google Patents
composição terapêutica que age por inibição das serinas proteasesInfo
- Publication number
- BRPI9800956B8 BRPI9800956B8 BRPI9800956A BRPI9800956A BRPI9800956B8 BR PI9800956 B8 BRPI9800956 B8 BR PI9800956B8 BR PI9800956 A BRPI9800956 A BR PI9800956A BR PI9800956 A BRPI9800956 A BR PI9800956A BR PI9800956 B8 BRPI9800956 B8 BR PI9800956B8
- Authority
- BR
- Brazil
- Prior art keywords
- serine proteases
- acts
- inhibiting serine
- equal
- independently represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C07F9/4012—Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
"composição farmacêutica que age por inibição das serinas proteases, e, medicamento" composições farmacêuticas que agem por inibição das serinas proteases, caracterizadas pelo fato de que compreendem, em associação com qualquer excipiente apropriado, pelo menos um composto de fórmula geral (i) seguinte: r~ 6~r~ 7~p~ (o) - (chr5)~ m~ - (chr4)~ n~ - si (or~ 1~) (or~ 2~) (r~ 3~) (i) na qual r~ 1~ e r~ 2~ cada um independentemente representam um átomo de hidrogênio ou um grupamento alquila, r~ 3~ representa um grupamento hidroxila, ou um grupamento alcoxi ou um grupamento alquila, r~ 4~ e r~ 5~ representam, cada um independentemente, um átomo de hidrogênio, um grupamento hidroxila, um grupamento alquila ou uma função de ácido carboxílica, r~ 6~ e r~ 7~ representa, cada um independentemente um grupamento alcoxi, n é um inteiro superior ou igual a 0 e inferior ou igual a 4, m é um inteiro estritamente superior a 0 e inferior ou igual a 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9703793A FR2761075B1 (fr) | 1997-03-24 | 1997-03-24 | Nouveaux composes a base de silicium biologiquement actifs et leurs applications therapeutiques |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI9800956B1 BRPI9800956B1 (pt) | 2018-09-11 |
BRPI9800956B8 true BRPI9800956B8 (pt) | 2021-05-25 |
Family
ID=9505261
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9800956A BRPI9800956B8 (pt) | 1997-03-24 | 1998-03-24 | composição terapêutica que age por inibição das serinas proteases |
BR9800956-7A BR9800956A (pt) | 1997-03-24 | 1998-03-24 | Composição farmacêutica que age por inibição das serinas proteases, e, medicamento |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9800956-7A BR9800956A (pt) | 1997-03-24 | 1998-03-24 | Composição farmacêutica que age por inibição das serinas proteases, e, medicamento |
Country Status (12)
Country | Link |
---|---|
US (1) | US6001389A (pt) |
EP (1) | EP0870504B1 (pt) |
JP (1) | JPH10279484A (pt) |
AR (1) | AR011998A1 (pt) |
AT (1) | ATE290538T1 (pt) |
BR (2) | BRPI9800956B8 (pt) |
CA (1) | CA2234500C (pt) |
DE (1) | DE69829236T2 (pt) |
DK (1) | DK0870504T3 (pt) |
ES (1) | ES2239384T3 (pt) |
FR (1) | FR2761075B1 (pt) |
PT (1) | PT870504E (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2799758B1 (fr) | 1999-10-15 | 2002-05-17 | Exsymol Sa | Complexe a base d'acide orthosilicique biologiquement assimilable, se presentant sous forme solide, stable et concentree, et procede de preparation |
US7195774B2 (en) * | 2001-08-29 | 2007-03-27 | Carvalho Ricardo Azevedo Ponte | Implantable and sealable system for unidirectional delivery of therapeutic agents to tissues |
EP1583765A4 (en) * | 2002-11-18 | 2008-03-26 | Grenpharma Llc | COMPOSITIONS FOR THE TREATMENT AND / OR PREVENTION OF DISEASES CHARACTERIZED BY THE PRESENCE OF METALLIC IONS |
US7595308B2 (en) * | 2002-11-18 | 2009-09-29 | Grenpharma Llc | Compositions for treating and/or preventing diseases characterized by the presence of metal ions |
WO2006047477A1 (en) * | 2004-10-22 | 2006-05-04 | Grenpharama Llc | Compositions for treating and/or preventing diseases characterized by the presence of the metal ions |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1090210B (de) * | 1956-05-31 | 1960-10-06 | Gen Electric | Verfahren zur Herstellung von Phosphonsaeureesterreste enthaltenden Organosiliciumverbindungen |
FR6871M (pt) * | 1966-12-23 | 1969-04-14 | ||
US3914416A (en) * | 1966-12-23 | 1975-10-21 | Exsymol Sa | Certain monomethyl trisilanol mannuronate complexes for treating cellulitis |
FR2610522B1 (fr) * | 1987-02-06 | 1989-08-18 | Gueyne Jean | Produit therapeutique a base de derives organiques du silicium |
JPH0532683A (ja) * | 1991-07-29 | 1993-02-09 | Sanwa Kagaku Kenkyusho Co Ltd | 有機ゲルマニウム並びに有機珪素化合物、その製法及び用途 |
FR2725207B1 (fr) * | 1994-09-30 | 1996-11-29 | Exsymol Sa | Composes a base de silicium biologiquement actifs, leurs applications therapeutiques et cosmetiques |
FR2725208B1 (fr) * | 1994-09-30 | 1996-11-29 | Exsymol Sa | Procede de preparation de composes de silicium biologiquement actifs sous forme concentree |
-
1997
- 1997-03-24 FR FR9703793A patent/FR2761075B1/fr not_active Expired - Fee Related
-
1998
- 1998-03-18 CA CA002234500A patent/CA2234500C/fr not_active Expired - Fee Related
- 1998-03-19 JP JP10070367A patent/JPH10279484A/ja active Pending
- 1998-03-23 EP EP98480017A patent/EP0870504B1/fr not_active Expired - Lifetime
- 1998-03-23 DE DE69829236T patent/DE69829236T2/de not_active Expired - Fee Related
- 1998-03-23 ES ES98480017T patent/ES2239384T3/es not_active Expired - Lifetime
- 1998-03-23 AT AT98480017T patent/ATE290538T1/de active
- 1998-03-23 PT PT98480017T patent/PT870504E/pt unknown
- 1998-03-23 AR ARP980101309A patent/AR011998A1/es not_active Application Discontinuation
- 1998-03-23 DK DK98480017T patent/DK0870504T3/da active
- 1998-03-24 BR BRPI9800956A patent/BRPI9800956B8/pt unknown
- 1998-03-24 BR BR9800956-7A patent/BR9800956A/pt not_active IP Right Cessation
- 1998-03-24 US US09/046,511 patent/US6001389A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0870504A2 (fr) | 1998-10-14 |
JPH10279484A (ja) | 1998-10-20 |
FR2761075A1 (fr) | 1998-09-25 |
US6001389A (en) | 1999-12-14 |
CA2234500C (fr) | 2009-08-25 |
FR2761075B1 (fr) | 1999-06-11 |
BR9800956A (pt) | 2001-03-13 |
DE69829236T2 (de) | 2006-02-02 |
CA2234500A1 (fr) | 1998-09-24 |
PT870504E (pt) | 2005-07-29 |
ES2239384T3 (es) | 2005-09-16 |
EP0870504B1 (fr) | 2005-03-09 |
AR011998A1 (es) | 2000-09-13 |
DE69829236D1 (de) | 2005-04-14 |
ATE290538T1 (de) | 2005-03-15 |
EP0870504A3 (fr) | 2002-09-11 |
BRPI9800956B1 (pt) | 2018-09-11 |
DK0870504T3 (da) | 2005-07-18 |
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