BRPI1102830F1 - Utilização da associação de um inibidor da corrente if sinusal e de um inibidor da enzima de conversão da angiotensina para o tratamento da insuficiência cardíaca - Google Patents

Utilização da associação de um inibidor da corrente if sinusal e de um inibidor da enzima de conversão da angiotensina para o tratamento da insuficiência cardíaca

Info

Publication number
BRPI1102830F1
BRPI1102830F1 BRPI1102830A BRPI1102830A BRPI1102830F1 BR PI1102830 F1 BRPI1102830 F1 BR PI1102830F1 BR PI1102830 A BRPI1102830 A BR PI1102830A BR PI1102830 A BRPI1102830 A BR PI1102830A BR PI1102830 F1 BRPI1102830 F1 BR PI1102830F1
Authority
BR
Brazil
Prior art keywords
heart failure
inhibitor
treatment
combination
sinus
Prior art date
Application number
BRPI1102830A
Other languages
English (en)
Inventor
Christian Thuillez
Guy Lerebours-Pigeonniere
Jean-Paul Vilaine
Jérôme Roussel
Luc Feldmann
Marie-Dominique Fratacci
Paulus Mulder
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42985210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1102830(F1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BRPI1102830A2 publication Critical patent/BRPI1102830A2/pt
Publication of BRPI1102830B1 publication Critical patent/BRPI1102830B1/pt
Publication of BRPI1102830B8 publication Critical patent/BRPI1102830B8/pt
Publication of BRPI1102830F1 publication Critical patent/BRPI1102830F1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

utilização da associação de um inibidor da corrente if sinusal e de um inibidor da enzima de conversão da angiotensina para o tratamento da insuficiência cardíaca a presente invenção refere-se da associação de um inibidor seletivo e específico da corrente if sinusal, mais especialmente a ivabradina ou a n-{[(7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetóxi-1,2,4,5-tetra-hidro-3h-3-benzazepin-3-il)-n-metil-3-oxo-1-propanamina e de um agente inibidor da enzima de conversão da angiotensina para a obtenção de medicamentos destinados ao tratamento da insuficiência cardíaca, mais especialmente da insuficiência cardíaca com função sistólica conservada.
BRPI1102830A 2010-06-15 2011-06-14 Utilização da associação de um inibidor da corrente if sinusal e de um inibidor da enzima de conversão da angiotensina para o tratamento da insuficiência cardíaca BRPI1102830F1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR10/02525 2010-06-15
FR1002525A FR2961105B1 (fr) 2010-06-15 2010-06-15 Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque

Publications (4)

Publication Number Publication Date
BRPI1102830A2 BRPI1102830A2 (pt) 2013-12-24
BRPI1102830B1 BRPI1102830B1 (pt) 2019-10-08
BRPI1102830B8 BRPI1102830B8 (pt) 2020-01-07
BRPI1102830F1 true BRPI1102830F1 (pt) 2022-03-29

Family

ID=42985210

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1102830A BRPI1102830F1 (pt) 2010-06-15 2011-06-14 Utilização da associação de um inibidor da corrente if sinusal e de um inibidor da enzima de conversão da angiotensina para o tratamento da insuficiência cardíaca

Country Status (46)

Country Link
US (1) US20110306598A1 (pt)
EP (2) EP2921168B1 (pt)
JP (1) JP5480202B2 (pt)
KR (1) KR101389879B1 (pt)
CN (2) CN104906579A (pt)
AP (2) AP3691A (pt)
AR (1) AR081875A1 (pt)
AU (1) AU2011202607B2 (pt)
BR (1) BRPI1102830F1 (pt)
CA (1) CA2743527C (pt)
CL (1) CL2011001420A1 (pt)
CO (1) CO6640265A2 (pt)
CR (1) CR20120609U (pt)
CU (1) CU24161B1 (pt)
CY (2) CY1116438T1 (pt)
DK (2) DK2404600T3 (pt)
EA (1) EA022612B1 (pt)
EC (1) ECSP12012337A (pt)
ES (2) ES2582157T3 (pt)
FR (1) FR2961105B1 (pt)
GE (1) GEP20146132B (pt)
GT (1) GT201200341A (pt)
HK (2) HK1210012A1 (pt)
HR (2) HRP20150745T1 (pt)
HU (2) HUE027088T2 (pt)
IL (1) IL223293A (pt)
JO (1) JO3309B1 (pt)
MA (1) MA33235B1 (pt)
ME (2) ME02476B (pt)
MX (1) MX2011006001A (pt)
MY (1) MY179034A (pt)
NI (1) NI201200182A (pt)
NZ (2) NZ593437A (pt)
PE (1) PE20120019A1 (pt)
PL (2) PL2921168T3 (pt)
PT (1) PT2404600E (pt)
RS (2) RS54838B1 (pt)
SA (2) SA114360089B1 (pt)
SG (2) SG177069A1 (pt)
SI (2) SI2921168T1 (pt)
TN (1) TN2012000551A1 (pt)
TW (1) TWI468164B (pt)
UA (1) UA108983C2 (pt)
UY (1) UY33423A (pt)
WO (1) WO2011157908A1 (pt)
ZA (1) ZA201104222B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603666A (zh) * 2012-02-28 2012-07-25 石河子大学 肉桂酰牛磺酰噻唑烷酸类化合物及其应用
FR3020810B1 (fr) * 2014-05-06 2016-05-06 Servier Lab Nouveau sel de l'ivabradine et son procede de preparation.
EP3025705B8 (en) * 2014-11-25 2018-11-28 Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi Stable ivabradine formulations
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
KR20190001340A (ko) * 2017-06-27 2019-01-04 에리슨제약(주) 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법
CN107714702A (zh) * 2017-10-31 2018-02-23 泰州中国医药城中医药研究院 一种伊伐布雷定和米力农组合物及其在制药中的应用
CN107550915A (zh) * 2017-10-31 2018-01-09 泰州中国医药城中医药研究院 一种伊伐布雷定和咯利普兰组合物及其在制药中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
US6188743B1 (en) * 1997-10-10 2001-02-13 Analogic Corporation Computed tomography scanner drive system and bearing
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
DE10018401A1 (de) * 2000-04-13 2001-10-25 Boehringer Ingelheim Pharma Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
DE60200160T2 (de) * 2002-07-25 2004-11-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Cilobradine oder pharmazeutisch akzeptablen Salze zur Behandlung oder Prävention von Herzversagen
RU2407523C2 (ru) * 2004-10-08 2010-12-27 Новартис Аг Применение ингибиторов ренина для профилактики или лечения диастолической дисфункции или диастолической сердечной недостаточности
WO2007014051A2 (en) * 2005-07-22 2007-02-01 Amylin Pharmaceuticals, Inc. Use of amylin and amylin agonists as cardioprotective or myoprotective agents
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2894825B1 (fr) * 2005-12-21 2010-12-03 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent
FR2911279B1 (fr) * 2007-01-11 2009-03-06 Servier Lab Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale
FR2920773B1 (fr) 2007-09-11 2009-10-23 Servier Lab Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2921365B1 (fr) 2007-09-21 2012-10-12 Servier Lab Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2927538B1 (fr) * 2008-02-14 2010-02-19 Servier Lab Association d'un inhibiteur du courant if sinusal et d'un beta-bloquant.
RU2364401C1 (ru) * 2008-05-12 2009-08-20 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" Способ коррекции сосудистого ремоделирования у больных хронической сердечной недостаточностью ишемической этиологии
WO2009158005A1 (en) * 2008-06-27 2009-12-30 Concert Pharmaceuticals, Inc. Benzazepinone compounds
RU2382644C1 (ru) 2008-11-05 2010-02-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" Способ коррекции гипертрофии левого желудочка у больных ибс в сочетании с гипертонической болезнью

Also Published As

Publication number Publication date
KR20110136752A (ko) 2011-12-21
TW201206445A (en) 2012-02-16
RS54077B1 (en) 2015-10-30
TWI468164B (zh) 2015-01-11
IL223293A0 (en) 2013-02-03
WO2011157908A1 (fr) 2011-12-22
PE20120019A1 (es) 2012-02-11
AP3691A (en) 2016-04-30
PT2404600E (pt) 2015-07-13
MX2011006001A (es) 2011-12-14
CL2011001420A1 (es) 2012-07-06
WO2011157908A8 (fr) 2013-01-17
CU24161B1 (es) 2016-03-31
ZA201104222B (en) 2012-02-29
UA108983C2 (en) 2015-07-10
KR101389879B1 (ko) 2014-04-29
CO6640265A2 (es) 2013-03-22
SI2404600T1 (sl) 2015-10-30
UY33423A (es) 2011-12-30
GT201200341A (es) 2014-03-14
SG10201500502WA (en) 2015-03-30
ME02476B (me) 2017-02-20
SA111320527B1 (ar) 2015-03-19
HK1210011A1 (zh) 2016-04-15
EA022612B1 (ru) 2016-02-29
CR20120609U (es) 2013-02-05
EP2404600B1 (fr) 2015-05-27
NZ600931A (en) 2013-04-26
BRPI1102830B1 (pt) 2019-10-08
EP2921168A1 (fr) 2015-09-23
CY1116438T1 (el) 2017-02-08
EP2921168B1 (fr) 2016-04-13
JP5480202B2 (ja) 2014-04-23
SG177069A1 (en) 2012-01-30
ES2545343T3 (es) 2015-09-10
CY1117724T1 (el) 2017-05-17
PL2404600T3 (pl) 2015-10-30
AR081875A1 (es) 2012-10-24
RS54838B1 (sr) 2016-10-31
FR2961105B1 (fr) 2013-02-08
AP2013006661A0 (en) 2013-01-31
CN104906579A (zh) 2015-09-16
SI2921168T1 (sl) 2016-08-31
EA201100773A1 (ru) 2011-12-30
DK2921168T3 (en) 2016-08-01
US20110306598A1 (en) 2011-12-15
AU2011202607A1 (en) 2012-01-12
PL2921168T3 (pl) 2016-10-31
CA2743527C (fr) 2016-08-02
BRPI1102830B8 (pt) 2020-01-07
SA114360089B1 (ar) 2016-02-03
NZ593437A (en) 2012-08-31
DK2404600T3 (en) 2015-08-31
HRP20150745T1 (hr) 2015-08-14
ME02163B (me) 2015-10-20
HK1210012A1 (en) 2016-04-15
MA33235B1 (fr) 2012-05-02
CU20120166A7 (es) 2013-04-19
AP2016009002A0 (en) 2016-01-31
NI201200182A (es) 2013-05-13
IL223293A (en) 2017-04-30
ES2582157T3 (es) 2016-09-09
HUE027088T2 (en) 2016-08-29
JP2012001545A (ja) 2012-01-05
GEP20146132B (en) 2014-08-11
AU2011202607B2 (en) 2015-02-12
ECSP12012337A (es) 2012-12-28
JO3309B1 (ar) 2018-09-16
BRPI1102830A2 (pt) 2013-12-24
CN102284060A (zh) 2011-12-21
FR2961105A1 (fr) 2011-12-16
CA2743527A1 (fr) 2011-12-15
MY179034A (en) 2020-10-26
HUE027788T2 (en) 2016-10-28
HRP20160643T1 (hr) 2016-07-01
TN2012000551A1 (fr) 2014-04-01
EP2404600A1 (fr) 2012-01-11

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