CL2011001420A1 - Uso de ivabradina o n-{[(7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3h-3-benzazepin-3-il)-n-metil-3-oxo-1-propanamina con perindopril, sales, hidratos o formas cristalinas de ellos, para el tratamiento de insuficiencia cardiaca con funcion sistolica conservada. - Google Patents
Uso de ivabradina o n-{[(7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3h-3-benzazepin-3-il)-n-metil-3-oxo-1-propanamina con perindopril, sales, hidratos o formas cristalinas de ellos, para el tratamiento de insuficiencia cardiaca con funcion sistolica conservada.Info
- Publication number
- CL2011001420A1 CL2011001420A1 CL2011001420A CL2011001420A CL2011001420A1 CL 2011001420 A1 CL2011001420 A1 CL 2011001420A1 CL 2011001420 A CL2011001420 A CL 2011001420A CL 2011001420 A CL2011001420 A CL 2011001420A CL 2011001420 A1 CL2011001420 A1 CL 2011001420A1
- Authority
- CL
- Chile
- Prior art keywords
- methyl
- heart failure
- ivabradine
- benzazepin
- propanamine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
UTILIZACIÓN DE LA ASOCIACIÓN DE UN INHIBIDOR SELECTIVO Y ESPECÍFICO DE LA CORRIENTE SINUSAL L, MÁS PARTICULARMENTE LA IVABRADINA O LA N-{[(7S)-3,4-DIMETOXIBICICLO[4.2.Q]OCTA-1 ,3,5-TRIEN-7-IL]METIL}-3-(7,8-DIMETOXI-1 ,2,4,5-TETRAHIDRO-3H-3-BENZAZEPIN-3-IL)-N-METIL-3-OXO-1-PROPANAMINA Y DE UN AGENTE INHIBIDOR DE LA ENZIMA DE CONVERSIÓN DE LA ANGIOTENSINA PARA LA OBTENCIÓN DE MEDICAMENTOS DESTINADOS AL TRATAMIENTO DE LA INSUFICIENCIA CARDIACA, MÁS PARTICULARMENTE DE LA INSUFICIENCIA CARDIACA CON FUNCIÓN SISTÓLICA CONSERVADA. MEDICAMENTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1002525A FR2961105B1 (fr) | 2010-06-15 | 2010-06-15 | Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2011001420A1 true CL2011001420A1 (es) | 2012-07-06 |
Family
ID=42985210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2011001420A CL2011001420A1 (es) | 2010-06-15 | 2011-06-10 | Uso de ivabradina o n-{[(7s)-3,4-dimetoxibiciclo[4.2.0]octa-1,3,5-trien-7-il]metil}-3-(7,8-dimetoxi-1,2,4,5-tetrahidro-3h-3-benzazepin-3-il)-n-metil-3-oxo-1-propanamina con perindopril, sales, hidratos o formas cristalinas de ellos, para el tratamiento de insuficiencia cardiaca con funcion sistolica conservada. |
Country Status (46)
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102603666A (zh) * | 2012-02-28 | 2012-07-25 | 石河子大学 | 肉桂酰牛磺酰噻唑烷酸类化合物及其应用 |
FR3020810B1 (fr) * | 2014-05-06 | 2016-05-06 | Servier Lab | Nouveau sel de l'ivabradine et son procede de preparation. |
EP3025705B8 (en) * | 2014-11-25 | 2018-11-28 | Sanofi Ilaç Sanayi ve Ticaret Anonim Sirketi | Stable ivabradine formulations |
FR3050380B1 (fr) | 2016-04-20 | 2020-07-10 | Les Laboratoires Servier | Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains. |
KR20190001340A (ko) * | 2017-06-27 | 2019-01-04 | 에리슨제약(주) | 이바브라딘을 포함하는 서방성 약제학적 조성물 및 이의 제조방법 |
CN107714702A (zh) * | 2017-10-31 | 2018-02-23 | 泰州中国医药城中医药研究院 | 一种伊伐布雷定和米力农组合物及其在制药中的应用 |
CN107550915A (zh) * | 2017-10-31 | 2018-01-09 | 泰州中国医药城中医药研究院 | 一种伊伐布雷定和咯利普兰组合物及其在制药中的应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
US6188743B1 (en) * | 1997-10-10 | 2001-02-13 | Analogic Corporation | Computed tomography scanner drive system and bearing |
FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
DE10018401A1 (de) * | 2000-04-13 | 2001-10-25 | Boehringer Ingelheim Pharma | Verwendung von Bradycardica bei der Behandlung von mit Hypertrophie einhergehenden Myocarderkrankungen und neue Arzneimittelkombinationen |
FR2838648B1 (fr) * | 2002-04-18 | 2004-05-21 | Servier Lab | Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent |
ES2211846T3 (es) * | 2002-07-25 | 2004-07-16 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Uso de cilobradina o sus sales farmaceuticamente aceptables para el tratamiento o la prevencion de la insuficiencia cardiaca. |
JP2008515903A (ja) * | 2004-10-08 | 2008-05-15 | ノバルティス アクチエンゲゼルシャフト | 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用 |
EP1912666A2 (en) * | 2005-07-22 | 2008-04-23 | Amylin Pharmaceuticals, Inc. | Use of amylin and amylin agonists as cardioprotective or myoprotective agents |
FR2891826B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2894825B1 (fr) * | 2005-12-21 | 2010-12-03 | Servier Lab | Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion et les compositions pharmaceutiques qui la contiennent |
FR2911279B1 (fr) * | 2007-01-11 | 2009-03-06 | Servier Lab | Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale |
FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2921365B1 (fr) * | 2007-09-21 | 2012-10-12 | Servier Lab | Nouveaux sels d'addition d'inhibiteurs d'enzyme de conversion de l'angiotensine a des acides donneurs de no, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2927538B1 (fr) * | 2008-02-14 | 2010-02-19 | Servier Lab | Association d'un inhibiteur du courant if sinusal et d'un beta-bloquant. |
RU2364401C1 (ru) * | 2008-05-12 | 2009-08-20 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции сосудистого ремоделирования у больных хронической сердечной недостаточностью ишемической этиологии |
WO2009158005A1 (en) * | 2008-06-27 | 2009-12-30 | Concert Pharmaceuticals, Inc. | Benzazepinone compounds |
RU2382644C1 (ru) * | 2008-11-05 | 2010-02-27 | Государственное образовательное учреждение высшего профессионального образования "Пермская государственная медицинская академия имени академика Е.А. Вагнера Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гипертрофии левого желудочка у больных ибс в сочетании с гипертонической болезнью |
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2010
- 2010-06-15 FR FR1002525A patent/FR2961105B1/fr not_active Expired - Fee Related
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2011
- 2011-05-31 AU AU2011202607A patent/AU2011202607B2/en not_active Ceased
- 2011-05-31 JO JOP/2011/0178A patent/JO3309B1/ar active
- 2011-05-31 PE PE2011001126A patent/PE20120019A1/es not_active Application Discontinuation
- 2011-05-31 SG SG10201500502WA patent/SG10201500502WA/en unknown
- 2011-05-31 SG SG2011039419A patent/SG177069A1/en unknown
- 2011-06-01 MY MYPI2011002498A patent/MY179034A/en unknown
- 2011-06-02 UY UY0001033423A patent/UY33423A/es not_active Application Discontinuation
- 2011-06-07 ZA ZA2011/04222A patent/ZA201104222B/en unknown
- 2011-06-07 MX MX2011006001A patent/MX2011006001A/es active IP Right Grant
- 2011-06-08 MA MA33924A patent/MA33235B1/fr unknown
- 2011-06-09 TW TW100120215A patent/TWI468164B/zh not_active IP Right Cessation
- 2011-06-10 CL CL2011001420A patent/CL2011001420A1/es unknown
- 2011-06-10 GE GEAP201112259A patent/GEP20146132B/en unknown
- 2011-06-10 CA CA2743527A patent/CA2743527C/fr not_active Expired - Fee Related
- 2011-06-13 NZ NZ600931A patent/NZ600931A/xx not_active IP Right Cessation
- 2011-06-13 SA SA111320527A patent/SA111320527B1/ar unknown
- 2011-06-13 SA SA114360089A patent/SA114360089B1/ar unknown
- 2011-06-13 NZ NZ593437A patent/NZ593437A/xx not_active IP Right Cessation
- 2011-06-13 AR ARP110102044A patent/AR081875A1/es unknown
- 2011-06-14 BR BRPI1102830A patent/BRPI1102830F1/pt not_active IP Right Cessation
- 2011-06-14 DK DK15162899.7T patent/DK2921168T3/en active
- 2011-06-14 EA EA201100773A patent/EA022612B1/ru unknown
- 2011-06-14 PT PT112902697T patent/PT2404600E/pt unknown
- 2011-06-14 ES ES11290269.7T patent/ES2545343T3/es active Active
- 2011-06-14 WO PCT/FR2011/000345 patent/WO2011157908A1/fr active Application Filing
- 2011-06-14 DK DK11290269.7T patent/DK2404600T3/en active
- 2011-06-14 ME MEP-2015-95A patent/ME02163B/me unknown
- 2011-06-14 PL PL11290269T patent/PL2404600T3/pl unknown
- 2011-06-14 SI SI201130879A patent/SI2921168T1/sl unknown
- 2011-06-14 CU CU20120166A patent/CU24161B1/es active IP Right Grant
- 2011-06-14 HU HUE15162899A patent/HUE027788T2/en unknown
- 2011-06-14 RS RS20160422A patent/RS54838B1/sr unknown
- 2011-06-14 ME MEP-2016-90A patent/ME02476B/me unknown
- 2011-06-14 AP AP2013006661A patent/AP3691A/xx active
- 2011-06-14 AP AP2016009002A patent/AP2016009002A0/xx unknown
- 2011-06-14 SI SI201130568T patent/SI2404600T1/sl unknown
- 2011-06-14 PL PL15162899.7T patent/PL2921168T3/pl unknown
- 2011-06-14 ES ES15162899.7T patent/ES2582157T3/es active Active
- 2011-06-14 US US13/134,667 patent/US20110306598A1/en not_active Abandoned
- 2011-06-14 EP EP15162899.7A patent/EP2921168B1/fr active Active
- 2011-06-14 EP EP11290269.7A patent/EP2404600B1/fr not_active Revoked
- 2011-06-14 HU HUE11290269A patent/HUE027088T2/en unknown
- 2011-06-14 KR KR1020110057585A patent/KR101389879B1/ko active IP Right Grant
- 2011-06-14 UA UAA201107469A patent/UA108983C2/en unknown
- 2011-06-14 RS RS20150435A patent/RS54077B1/en unknown
- 2011-06-15 CN CN201510337337.6A patent/CN104906579A/zh active Pending
- 2011-06-15 CN CN2011101600748A patent/CN102284060A/zh active Pending
- 2011-06-15 JP JP2011132849A patent/JP5480202B2/ja active Active
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2012
- 2012-11-23 TN TNP2012000551A patent/TN2012000551A1/fr unknown
- 2012-11-27 IL IL223293A patent/IL223293A/en active IP Right Grant
- 2012-12-03 CR CR20120609U patent/CR20120609U/es unknown
- 2012-12-07 NI NI201200182A patent/NI201200182A/es unknown
- 2012-12-10 CO CO12223070A patent/CO6640265A2/es not_active Application Discontinuation
- 2012-12-14 GT GT201200341A patent/GT201200341A/es unknown
- 2012-12-14 EC ECSP12012337 patent/ECSP12012337A/es unknown
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2015
- 2015-06-08 CY CY20151100503T patent/CY1116438T1/el unknown
- 2015-07-08 HR HRP20150745TT patent/HRP20150745T1/hr unknown
- 2015-10-28 HK HK15110661.0A patent/HK1210012A1/xx unknown
- 2015-10-28 HK HK15110660.1A patent/HK1210011A1/zh not_active IP Right Cessation
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2016
- 2016-06-09 HR HRP20160643TT patent/HRP20160643T1/hr unknown
- 2016-06-10 CY CY20161100508T patent/CY1117724T1/el unknown
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