BRPI1016083A2 - processo para preparação de sais pirrolidínio - Google Patents
processo para preparação de sais pirrolidínioInfo
- Publication number
- BRPI1016083A2 BRPI1016083A2 BRPI1016083A BRPI1016083A BRPI1016083A2 BR PI1016083 A2 BRPI1016083 A2 BR PI1016083A2 BR PI1016083 A BRPI1016083 A BR PI1016083A BR PI1016083 A BRPI1016083 A BR PI1016083A BR PI1016083 A2 BRPI1016083 A2 BR PI1016083A2
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- pyrrolidinium salts
- pyrrolidinium
- salts
- preparing pyrrolidinium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16797709P | 2009-04-09 | 2009-04-09 | |
| PCT/EP2010/054610 WO2010115937A1 (en) | 2009-04-09 | 2010-04-07 | Process for preparing pyrrolidinium salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI1016083A2 true BRPI1016083A2 (pt) | 2016-05-10 |
| BRPI1016083A8 BRPI1016083A8 (pt) | 2017-10-10 |
Family
ID=42200985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1016083A BRPI1016083A8 (pt) | 2009-04-09 | 2010-04-07 | processo para preparação de sais de pirrolidínio |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120022127A1 (pt) |
| EP (1) | EP2417106B1 (pt) |
| JP (2) | JP5902612B2 (pt) |
| KR (1) | KR101290893B1 (pt) |
| CN (1) | CN102388021B (pt) |
| AU (1) | AU2010233772B2 (pt) |
| BR (1) | BRPI1016083A8 (pt) |
| CA (1) | CA2758100C (pt) |
| ES (1) | ES2617680T3 (pt) |
| MX (1) | MX344153B (pt) |
| PL (1) | PL2417106T3 (pt) |
| PT (1) | PT2417106T (pt) |
| RU (1) | RU2554878C2 (pt) |
| WO (1) | WO2010115937A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011157387A1 (en) * | 2010-06-14 | 2011-12-22 | Chiesi Farmaceutici S.P.A. | Crystal form of glycopyrronium chloride |
| CN102627595A (zh) * | 2012-03-09 | 2012-08-08 | 徐奎 | 一种制备格隆溴铵的方法 |
| US8558008B2 (en) | 2013-02-28 | 2013-10-15 | Dermira, Inc. | Crystalline glycopyrrolate tosylate |
| US9006462B2 (en) | 2013-02-28 | 2015-04-14 | Dermira, Inc. | Glycopyrrolate salts |
| JP6114841B2 (ja) | 2013-02-28 | 2017-04-12 | ダーミラ， インク．Ｄｅｒｍｉｒａ， Ｉｎｃ． | グリコピロレート塩 |
| US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
| CN105175304A (zh) * | 2013-11-13 | 2015-12-23 | 李兴惠 | 抗胆碱药物格隆溴铵及组合物 |
| CN103819384A (zh) * | 2013-12-05 | 2014-05-28 | 广东嘉博制药有限公司 | 一种格隆溴铵的制备方法 |
| US9926270B2 (en) | 2014-08-20 | 2018-03-27 | Dermira, Inc. | Process for production of glycopyrronium tosylate |
| LT3191081T (lt) | 2014-09-09 | 2020-07-10 | Vectura Limited | Vaisto forma, apimanti glikopiroliatą, būdas ir aparatūra |
| CN107304178B (zh) * | 2016-04-21 | 2020-03-27 | 辽宁药联制药有限公司 | 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法 |
| US10906871B2 (en) * | 2016-08-02 | 2021-02-02 | Dermira, Inc. | Processes for making, and methods of using, glycopyrronium compounds |
| CN107915666A (zh) * | 2016-10-09 | 2018-04-17 | 四川海思科制药有限公司 | 一种格隆溴铵化合物 |
| US10954191B2 (en) | 2017-03-12 | 2021-03-23 | Sol-Gel Technologies Ltd. | Process for the preparation of glycopyrrolate tosylate |
| EP3658537A4 (en) | 2017-07-27 | 2021-03-31 | Sol-Gel Technologies Ltd. | PROCESS FOR THE PREPARATION OF GLYCOPYRROLATE TOSYLATE |
| WO2020148777A1 (en) * | 2019-01-14 | 2020-07-23 | Neon Laboratories Limited | Process for preparation of glycopyrrolate intermediate |
| CN111349036B (zh) * | 2020-03-13 | 2022-03-08 | 安徽恒星制药有限公司 | 一种格隆溴铵的替代物及其制备方法和医药用途 |
| WO2022079194A1 (en) | 2020-10-14 | 2022-04-21 | Pcas | Process for the production of glycopyrronium tosylate |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2956062A (en) * | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
| DE2046659A1 (pt) | 1970-01-28 | 1972-03-23 | ||
| FR2081497B1 (pt) * | 1970-02-09 | 1974-08-02 | Sandoz Sa | |
| IT1016489B (it) | 1974-03-18 | 1977-05-30 | Isf Spa | Inalatore |
| ATE261324T1 (de) | 1995-12-07 | 2004-03-15 | Jago Res Ag | Mundstück für einen inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers |
| DK0883415T3 (da) | 1996-02-21 | 2002-08-19 | Schering Corp | Inhalator til pulverformigt medikament |
| US6613795B2 (en) * | 1996-11-11 | 2003-09-02 | Christian Noe | Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments |
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2206021B1 (es) * | 2002-04-16 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de pirrolidinio. |
| AT412088B (de) | 2002-12-18 | 2004-09-27 | Pharmacon Forschung & Beratung Gmbh | Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere |
| ES2239546B1 (es) * | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
| GB0410712D0 (en) | 2004-05-13 | 2004-06-16 | Novartis Ag | Organic compounds |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0504463D0 (en) * | 2005-03-03 | 2005-04-13 | Arakis Ltd | Method of crystallisation and purification |
| US7399861B2 (en) | 2005-11-10 | 2008-07-15 | Bodor Nicholas S | Soft anticholinergic esters |
| GB0525254D0 (en) | 2005-12-12 | 2006-01-18 | Jagotec Ag | Powder compositions for inhalation |
| US20100222393A1 (en) | 2005-12-30 | 2010-09-02 | Naresh Kumar | Muscarinic receptor antagonists |
| GB0613161D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
-
2010
- 2010-04-07 KR KR1020117026596A patent/KR101290893B1/ko active IP Right Grant
- 2010-04-07 BR BRPI1016083A patent/BRPI1016083A8/pt not_active IP Right Cessation
- 2010-04-07 AU AU2010233772A patent/AU2010233772B2/en active Active
- 2010-04-07 RU RU2011145051/04A patent/RU2554878C2/ru active
- 2010-04-07 CN CN201080014739.8A patent/CN102388021B/zh active Active
- 2010-04-07 PL PL10713193T patent/PL2417106T3/pl unknown
- 2010-04-07 US US13/260,952 patent/US20120022127A1/en not_active Abandoned
- 2010-04-07 ES ES10713193.0T patent/ES2617680T3/es active Active
- 2010-04-07 CA CA2758100A patent/CA2758100C/en active Active
- 2010-04-07 WO PCT/EP2010/054610 patent/WO2010115937A1/en active Application Filing
- 2010-04-07 PT PT107131930T patent/PT2417106T/pt unknown
- 2010-04-07 EP EP10713193.0A patent/EP2417106B1/en not_active Revoked
- 2010-04-07 MX MX2011010657A patent/MX344153B/es active IP Right Grant
- 2010-04-07 JP JP2012504011A patent/JP5902612B2/ja active Active
-
2014
- 2014-08-08 JP JP2014162879A patent/JP2015007081A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL2417106T3 (pl) | 2017-05-31 |
| BRPI1016083A8 (pt) | 2017-10-10 |
| EP2417106A1 (en) | 2012-02-15 |
| MX2011010657A (es) | 2011-10-21 |
| PT2417106T (pt) | 2017-02-13 |
| US20120022127A1 (en) | 2012-01-26 |
| CN102388021A (zh) | 2012-03-21 |
| JP2015007081A (ja) | 2015-01-15 |
| JP5902612B2 (ja) | 2016-04-13 |
| AU2010233772B2 (en) | 2014-04-24 |
| RU2011145051A (ru) | 2013-05-20 |
| CN102388021B (zh) | 2015-02-18 |
| ES2617680T3 (es) | 2017-06-19 |
| CA2758100C (en) | 2017-08-29 |
| EP2417106B1 (en) | 2016-11-30 |
| KR20120013370A (ko) | 2012-02-14 |
| RU2554878C2 (ru) | 2015-06-27 |
| MX344153B (es) | 2016-12-07 |
| AU2010233772A1 (en) | 2011-10-06 |
| CA2758100A1 (en) | 2010-10-14 |
| WO2010115937A1 (en) | 2010-10-14 |
| KR101290893B1 (ko) | 2013-07-29 |
| JP2012523390A (ja) | 2012-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2509 DE 05-02-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |