BRPI1014684A2 - novos derivados de isoquinolina - Google Patents
novos derivados de isoquinolinaInfo
- Publication number
- BRPI1014684A2 BRPI1014684A2 BRPI1014684A BRPI1014684A BRPI1014684A2 BR PI1014684 A2 BRPI1014684 A2 BR PI1014684A2 BR PI1014684 A BRPI1014684 A BR PI1014684A BR PI1014684 A BRPI1014684 A BR PI1014684A BR PI1014684 A2 BRPI1014684 A2 BR PI1014684A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoquinoline derivatives
- new isoquinoline
- new
- derivatives
- isoquinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009071693 | 2009-05-08 | ||
| PCT/EP2010/056062 WO2010128061A1 (en) | 2009-05-08 | 2010-05-05 | Novel isoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1014684A2 true BRPI1014684A2 (pt) | 2016-04-12 |
Family
ID=42272377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1014684A BRPI1014684A2 (pt) | 2009-05-08 | 2010-05-05 | novos derivados de isoquinolina |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8258149B2 (pt) |
| EP (1) | EP2427460B1 (pt) |
| JP (1) | JP2012526077A (pt) |
| KR (1) | KR20120007549A (pt) |
| CN (1) | CN102421774A (pt) |
| AU (1) | AU2010244473A1 (pt) |
| BR (1) | BRPI1014684A2 (pt) |
| CA (1) | CA2760339A1 (pt) |
| ES (1) | ES2462498T3 (pt) |
| IL (1) | IL216062A0 (pt) |
| MX (1) | MX2011011716A (pt) |
| SG (1) | SG175926A1 (pt) |
| WO (1) | WO2010128061A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102796096B (zh) * | 2011-05-27 | 2016-09-14 | 中国科学院上海药物研究所 | 六氢二苯并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用 |
| US9181237B2 (en) | 2013-10-04 | 2015-11-10 | Mallinckrodt Llc | Substituted berbines and their synthesis |
| KR101656394B1 (ko) * | 2013-12-31 | 2016-09-23 | 한국화학연구원 | 신규한 8-옥소프로토베르베린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 nfat5의 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| WO2015102380A1 (ko) * | 2013-12-31 | 2015-07-09 | 한국화학연구원 | 신규한 8-옥소프로토베르베린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 nfat5의 활성 관련 질환의 예방 또는 치료용 약학적 조성물 |
| CN117813305A (zh) * | 2022-03-16 | 2024-04-02 | 南京施江医药科技有限公司 | 一种含氮杂环类化合物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000021073A (ko) * | 1998-09-25 | 2000-04-15 | 박원배 | 콜레스테롤 생합성 저해제 |
| JP4774212B2 (ja) * | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
| CN1759834B (zh) * | 2004-09-17 | 2010-06-23 | 中国医学科学院医药生物技术研究所 | 黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途 |
| US7572809B2 (en) * | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
| CN101153039B (zh) | 2006-09-30 | 2010-12-01 | 中国科学院上海药物研究所 | 13，13a-二氢小檗碱衍生物及其药物组合物和用途 |
| CN100494193C (zh) * | 2006-12-14 | 2009-06-03 | 西南大学 | 8-辛基小檗碱盐酸盐、合成方法及应用 |
| CN101104618B (zh) * | 2007-05-25 | 2010-05-26 | 西南大学 | 长链烷基小檗碱盐衍生物、合成方法及用途 |
| US8003795B2 (en) * | 2007-06-22 | 2011-08-23 | Cvi Pharmaceuticals Limited | Compounds and compositions for reducing lipid levels |
| EP2014651A1 (en) | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
-
2010
- 2010-04-30 US US12/770,816 patent/US8258149B2/en not_active Expired - Fee Related
- 2010-05-05 CA CA2760339A patent/CA2760339A1/en not_active Abandoned
- 2010-05-05 WO PCT/EP2010/056062 patent/WO2010128061A1/en active Application Filing
- 2010-05-05 CN CN2010800200667A patent/CN102421774A/zh active Pending
- 2010-05-05 KR KR1020117029275A patent/KR20120007549A/ko not_active Application Discontinuation
- 2010-05-05 AU AU2010244473A patent/AU2010244473A1/en not_active Abandoned
- 2010-05-05 MX MX2011011716A patent/MX2011011716A/es active IP Right Grant
- 2010-05-05 BR BRPI1014684A patent/BRPI1014684A2/pt not_active IP Right Cessation
- 2010-05-05 EP EP10719594.3A patent/EP2427460B1/en not_active Not-in-force
- 2010-05-05 JP JP2012509019A patent/JP2012526077A/ja active Pending
- 2010-05-05 SG SG2011081924A patent/SG175926A1/en unknown
- 2010-05-05 ES ES10719594.3T patent/ES2462498T3/es active Active
-
2011
- 2011-10-31 IL IL216062A patent/IL216062A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2462498T3 (es) | 2014-05-23 |
| EP2427460B1 (en) | 2014-03-26 |
| US8258149B2 (en) | 2012-09-04 |
| KR20120007549A (ko) | 2012-01-20 |
| MX2011011716A (es) | 2012-01-03 |
| JP2012526077A (ja) | 2012-10-25 |
| AU2010244473A1 (en) | 2011-12-15 |
| EP2427460A1 (en) | 2012-03-14 |
| WO2010128061A1 (en) | 2010-11-11 |
| US20100286396A1 (en) | 2010-11-11 |
| CA2760339A1 (en) | 2010-11-11 |
| SG175926A1 (en) | 2011-12-29 |
| IL216062A0 (en) | 2012-01-31 |
| CN102421774A (zh) | 2012-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI1013246A2 (pt) | derivados de benzofuralina | |
| BR112012002828A2 (pt) | derivados de 5-fluorpirimidinona | |
| BRPI1011683A2 (pt) | derivado isoquinolina substituída | |
| BR112012004969A2 (pt) | derivados de bis-benzimidazol | |
| BR112012002662A2 (pt) | derivados de bis-benzimidazol | |
| BRPI1013844A2 (pt) | derivados de piridina-isoxazol | |
| ECSP12011999A (es) | Derivados benzamida sustituidos | |
| BR112012000763A2 (pt) | derivados de piridin-4-ila | |
| DE112010002949A5 (de) | Kupplungstastpunkte | |
| BRPI1008774A2 (pt) | espiroamida substituída | |
| DK2397480T3 (da) | Diazepindionderivat | |
| BRPI1008827A2 (pt) | deisobutenizador | |
| BRPI1014968A2 (pt) | subalargador | |
| BRPI1014454A2 (pt) | derivados de isoxazol-pirazol | |
| DE112010002728A5 (de) | Turboinhalator | |
| DE112009005323A5 (de) | Hebelarmprüfmaschine | |
| DK2387580T3 (da) | Deoxyactagardinderivater | |
| BR112012000657A2 (pt) | novos azabicilohexanos | |
| DE112009005462T8 (de) | Lenkungsssteuervorrichtung | |
| BR112012004964A2 (pt) | girocóptero | |
| BRPI1008070A2 (pt) | tricianoboratos | |
| BRPI1011416A2 (pt) | derivados de antraquinova novos | |
| BR112012002810A2 (pt) | derivados de n1-acil-5-fluoropirimidinona | |
| BRPI1007369A2 (pt) | derivados de di-hidroquinolinona | |
| FR2947857B1 (fr) | Agencement de deshuileur |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |