BRPI1014627A2 - Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina - Google Patents

Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina

Info

Publication number
BRPI1014627A2
BRPI1014627A2 BRPI1014627-0A BRPI1014627A BRPI1014627A2 BR PI1014627 A2 BRPI1014627 A2 BR PI1014627A2 BR PI1014627 A BRPI1014627 A BR PI1014627A BR PI1014627 A2 BRPI1014627 A2 BR PI1014627A2
Authority
BR
Brazil
Prior art keywords
methylphenyl
methylthiazolo
cyclopropyl
fluoro
chloro
Prior art date
Application number
BRPI1014627-0A
Other languages
English (en)
Inventor
Zsolt Parkanyi
János Fazekas
Péter Miskolczi
Annamária Molnár
Béla Ágai
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BRPI1014627A2 publication Critical patent/BRPI1014627A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/02—Thiocyanates
    • C07C331/04—Thiocyanates having sulfur atoms of thiocyanate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/12—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
    • C08F216/14—Monomers containing only one unsaturated aliphatic radical
    • C08F216/1466—Monomers containing sulfur
    • C08F216/1483—Monomers containing sulfur and nitrogen
BRPI1014627-0A 2009-04-30 2010-04-26 Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina BRPI1014627A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0900267A HUP0900267A2 (en) 2009-04-30 2009-04-30 Process for preparing of thiazole amines and intermediates thereof
PCT/HU2010/000047 WO2010125414A1 (en) 2009-04-30 2010-04-26 Process for the preparation of [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-yl]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine

Publications (1)

Publication Number Publication Date
BRPI1014627A2 true BRPI1014627A2 (pt) 2015-08-25

Family

ID=89988941

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1014627-0A BRPI1014627A2 (pt) 2009-04-30 2010-04-26 Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina

Country Status (19)

Country Link
US (1) US8314249B2 (pt)
EP (1) EP2424848B1 (pt)
JP (1) JP5608221B2 (pt)
KR (1) KR20120014005A (pt)
CN (1) CN102414185B (pt)
AR (1) AR076478A1 (pt)
AU (1) AU2010243362B2 (pt)
BR (1) BRPI1014627A2 (pt)
CA (1) CA2760384A1 (pt)
HU (1) HUP0900267A2 (pt)
IL (1) IL216017A0 (pt)
IN (1) IN2011KN04192A (pt)
MX (1) MX2011011530A (pt)
MY (1) MY152269A (pt)
RU (1) RU2523793C2 (pt)
SG (1) SG175829A1 (pt)
TW (1) TWI461413B (pt)
UY (1) UY32594A (pt)
WO (1) WO2010125414A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8943551B2 (en) * 2008-08-14 2015-01-27 Microsoft Corporation Cloud-based device information storage
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof
NZ722122A (en) 2014-01-21 2020-06-26 Neurocrine Biosciences Inc Crf1 receptor antagonists for the treatment of congenital adrenal hyperplasia
US10207974B1 (en) 2017-12-05 2019-02-19 Chevron Phillips Chemical Company Lp Synthesis of gamma dicarbonyl and pyrrole compounds
TW202033193A (zh) * 2018-12-07 2020-09-16 美商紐羅克里生物科學有限公司 用於治療先天性腎上腺增生之crf1受體拮抗劑、醫藥配方及其固體形式
EP4034111A1 (en) * 2019-09-27 2022-08-03 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods of use
JOP20220329A1 (ar) 2020-06-10 2023-01-30 مضاد مستقبل crf1 لعلاج فرط تنسج الكظر الخلقي

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB823251A (en) 1955-07-02 1959-11-11 Thomae Gmbh Dr K Improvements in or relating to preparations containing benzoxathiol derivatives for the care of hair and skin
US3222248A (en) * 1961-12-12 1965-12-07 Stauffer Chemical Co Method of controlling microorganisms by means of organic thiocyanates
US3433803A (en) 1966-12-01 1969-03-18 Olin Mathieson Substituted imino-1,3-oxathiols and their preparation
IL103586A (en) 1991-10-30 1997-09-30 Astra Ab Process for the preparation of 4-methyl-5- (2-chloroethyl)-thiazole and analogues thereof
JPH1036360A (ja) 1996-02-21 1998-02-10 Kuraray Co Ltd ２−クロロ−５−クロロメチル−１，３−チアゾールの製造方法
FR2796380B3 (fr) * 1999-07-15 2001-08-17 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant
HUP0900267A2 (en) 2009-04-30 2011-03-28 Sanofi Aventis Process for preparing of thiazole amines and intermediates thereof

Also Published As

Publication number Publication date
IL216017A0 (en) 2012-01-31
CN102414185B (zh) 2014-02-26
RU2523793C2 (ru) 2014-07-27
AU2010243362B2 (en) 2015-07-30
US8314249B2 (en) 2012-11-20
CN102414185A (zh) 2012-04-11
WO2010125414A8 (en) 2011-04-07
TW201105640A (en) 2011-02-16
JP5608221B2 (ja) 2014-10-15
KR20120014005A (ko) 2012-02-15
TWI461413B (zh) 2014-11-21
EP2424848B1 (en) 2013-03-13
AU2010243362A1 (en) 2011-11-17
US20120083608A1 (en) 2012-04-05
SG175829A1 (en) 2011-12-29
HU0900267D0 (en) 2009-07-28
CA2760384A1 (en) 2010-11-04
WO2010125414A1 (en) 2010-11-04
MX2011011530A (es) 2011-11-18
RU2011148584A (ru) 2013-06-10
AR076478A1 (es) 2011-06-15
UY32594A (es) 2010-11-30
HUP0900267A2 (en) 2011-03-28
JP2012525368A (ja) 2012-10-22
IN2011KN04192A (pt) 2015-10-02
MY152269A (en) 2014-09-15
EP2424848A1 (en) 2012-03-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]