BRPI1014627A2 - Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina - Google Patents
Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-aminaInfo
- Publication number
- BRPI1014627A2 BRPI1014627A2 BRPI1014627-0A BRPI1014627A BRPI1014627A2 BR PI1014627 A2 BRPI1014627 A2 BR PI1014627A2 BR PI1014627 A BRPI1014627 A BR PI1014627A BR PI1014627 A2 BRPI1014627 A2 BR PI1014627A2
- Authority
- BR
- Brazil
- Prior art keywords
- methylphenyl
- methylthiazolo
- cyclopropyl
- fluoro
- chloro
- Prior art date
Links
- -1 2-chloro-4-methoxy-5-methylphenyl Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/04—Thiocyanates having sulfur atoms of thiocyanate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
- C08F216/12—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
- C08F216/14—Monomers containing only one unsaturated aliphatic radical
- C08F216/1466—Monomers containing sulfur
- C08F216/1483—Monomers containing sulfur and nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900267A HUP0900267A2 (en) | 2009-04-30 | 2009-04-30 | Process for preparing of thiazole amines and intermediates thereof |
| PCT/HU2010/000047 WO2010125414A1 (en) | 2009-04-30 | 2010-04-26 | Process for the preparation of [4-(2-chloro-4-methoxy-5-methylphenyl)-5-methyl-thiazolo-2-yl]-[2-cyclopropyl-1-(3-fluoro-4-methylphenyl)-ethyl]-amine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1014627A2 true BRPI1014627A2 (pt) | 2015-08-25 |
Family
ID=89988941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1014627-0A BRPI1014627A2 (pt) | 2009-04-30 | 2010-04-26 | Processo para a preparação de [4-(2-cloro-4-metóxi-5-metilfenil)-5-metil-tiazolo-2-il]-[ 2-ciclopropil-1-(3-flúor-4-metilfenil)-etil]-amina |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8314249B2 (pt) |
| EP (1) | EP2424848B1 (pt) |
| JP (1) | JP5608221B2 (pt) |
| KR (1) | KR20120014005A (pt) |
| CN (1) | CN102414185B (pt) |
| AR (1) | AR076478A1 (pt) |
| AU (1) | AU2010243362B2 (pt) |
| BR (1) | BRPI1014627A2 (pt) |
| CA (1) | CA2760384A1 (pt) |
| HU (1) | HUP0900267A2 (pt) |
| IL (1) | IL216017A0 (pt) |
| IN (1) | IN2011KN04192A (pt) |
| MX (1) | MX2011011530A (pt) |
| MY (1) | MY152269A (pt) |
| RU (1) | RU2523793C2 (pt) |
| SG (1) | SG175829A1 (pt) |
| TW (1) | TWI461413B (pt) |
| UY (1) | UY32594A (pt) |
| WO (1) | WO2010125414A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8943551B2 (en) * | 2008-08-14 | 2015-01-27 | Microsoft Corporation | Cloud-based device information storage |
| HUP0900267A2 (en) | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
| IL296683B2 (en) | 2014-01-21 | 2023-12-01 | Neurocrine Biosciences Inc | Preparations for the treatment of congenital adrenal hyperplasia |
| US10207974B1 (en) | 2017-12-05 | 2019-02-19 | Chevron Phillips Chemical Company Lp | Synthesis of gamma dicarbonyl and pyrrole compounds |
| CA3121920A1 (en) * | 2018-12-07 | 2020-06-11 | Neurocrine Biosciences, Inc. | Crf1 receptor antagonist, pharmaceutical formulations and solid forms thereof for the treatment of congenital adrenal hyperplasia |
| EP4034111A1 (en) * | 2019-09-27 | 2022-08-03 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods of use |
| KR20230038458A (ko) | 2020-06-10 | 2023-03-20 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 선천성 부신 증식증의 치료를 위한 crf1 수용체 길항제 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB823251A (en) | 1955-07-02 | 1959-11-11 | Thomae Gmbh Dr K | Improvements in or relating to preparations containing benzoxathiol derivatives for the care of hair and skin |
| US3222248A (en) * | 1961-12-12 | 1965-12-07 | Stauffer Chemical Co | Method of controlling microorganisms by means of organic thiocyanates |
| US3433803A (en) | 1966-12-01 | 1969-03-18 | Olin Mathieson | Substituted imino-1,3-oxathiols and their preparation |
| HRP921128B1 (en) | 1991-10-30 | 1998-10-31 | Sandor Garaczy | Novel process for the preparation of 4-methyl-5(2-chloroethyl)-thiazole and analogues thereof |
| JPH1036360A (ja) | 1996-02-21 | 1998-02-10 | Kuraray Co Ltd | ２−クロロ−５−クロロメチル−１，３−チアゾールの製造方法 |
| FR2796380B3 (fr) * | 1999-07-15 | 2001-08-17 | Sanofi Synthelabo | Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant |
| HUP0900267A2 (en) | 2009-04-30 | 2011-03-28 | Sanofi Aventis | Process for preparing of thiazole amines and intermediates thereof |
-
2009
- 2009-04-30 HU HU0900267A patent/HUP0900267A2/hu unknown
-
2010
- 2010-04-26 KR KR1020117028054A patent/KR20120014005A/ko not_active Application Discontinuation
- 2010-04-26 SG SG2011079696A patent/SG175829A1/en unknown
- 2010-04-26 RU RU2011148584/04A patent/RU2523793C2/ru not_active IP Right Cessation
- 2010-04-26 MX MX2011011530A patent/MX2011011530A/es active IP Right Grant
- 2010-04-26 CN CN201080018790.6A patent/CN102414185B/zh not_active Expired - Fee Related
- 2010-04-26 BR BRPI1014627-0A patent/BRPI1014627A2/pt not_active IP Right Cessation
- 2010-04-26 MY MYPI2011005171 patent/MY152269A/en unknown
- 2010-04-26 EP EP10718684A patent/EP2424848B1/en not_active Not-in-force
- 2010-04-26 CA CA2760384A patent/CA2760384A1/en active Pending
- 2010-04-26 JP JP2012507828A patent/JP5608221B2/ja not_active Expired - Fee Related
- 2010-04-26 WO PCT/HU2010/000047 patent/WO2010125414A1/en active Application Filing
- 2010-04-26 IN IN4192KON2011 patent/IN2011KN04192A/en unknown
- 2010-04-26 AU AU2010243362A patent/AU2010243362B2/en not_active Ceased
- 2010-04-28 AR ARP100101422A patent/AR076478A1/es unknown
- 2010-04-29 TW TW099113599A patent/TWI461413B/zh not_active IP Right Cessation
- 2010-04-30 UY UY0001032594A patent/UY32594A/es not_active Application Discontinuation
-
2011
- 2011-10-27 US US13/282,721 patent/US8314249B2/en not_active Expired - Fee Related
- 2011-10-27 IL IL216017A patent/IL216017A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU0900267D0 (en) | 2009-07-28 |
| RU2011148584A (ru) | 2013-06-10 |
| AU2010243362B2 (en) | 2015-07-30 |
| CN102414185A (zh) | 2012-04-11 |
| CA2760384A1 (en) | 2010-11-04 |
| HUP0900267A2 (en) | 2011-03-28 |
| WO2010125414A1 (en) | 2010-11-04 |
| KR20120014005A (ko) | 2012-02-15 |
| EP2424848B1 (en) | 2013-03-13 |
| RU2523793C2 (ru) | 2014-07-27 |
| EP2424848A1 (en) | 2012-03-07 |
| MY152269A (en) | 2014-09-15 |
| SG175829A1 (en) | 2011-12-29 |
| UY32594A (es) | 2010-11-30 |
| AU2010243362A1 (en) | 2011-11-17 |
| JP5608221B2 (ja) | 2014-10-15 |
| TWI461413B (zh) | 2014-11-21 |
| CN102414185B (zh) | 2014-02-26 |
| IL216017A0 (en) | 2012-01-31 |
| US8314249B2 (en) | 2012-11-20 |
| WO2010125414A8 (en) | 2011-04-07 |
| IN2011KN04192A (pt) | 2015-10-02 |
| TW201105640A (en) | 2011-02-16 |
| JP2012525368A (ja) | 2012-10-22 |
| US20120083608A1 (en) | 2012-04-05 |
| MX2011011530A (es) | 2011-11-18 |
| AR076478A1 (es) | 2011-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |